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BRENDA KEGG MetaCyc

cholesterol biosynthesis (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences2.5.1.103 presqualene diphosphate synthase 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate cholesterol biosynthesis Steroid biosynthesis,
Carotenoid biosynthesis,
Sesquiterpenoid and triterpenoid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
hopanoid biosynthesis (bacteria),
botryococcenes and methylated squalene biosynthesis,
4,4'-diapolycopenedioate biosynthesis,
staphyloxanthin biosynthesis
BR49808 show the reaction diagram R00702 show the reaction diagram RXN-12263 show the reaction diagram 1080
show all sequences2.5.1.21 squalene synthase 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate cholesterol biosynthesis Steroid biosynthesis,
Carotenoid biosynthesis,
Sesquiterpenoid and triterpenoid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
hopanoid biosynthesis (bacteria),
botryococcenes and methylated squalene biosynthesis,
4,4'-diapolycopenedioate biosynthesis,
staphyloxanthin biosynthesis
BR49808 show the reaction diagram R00702 show the reaction diagram RXN-12263 show the reaction diagram 1080
show all sequences2.5.1.96 4,4'-diapophytoene synthase 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate cholesterol biosynthesis Steroid biosynthesis,
Carotenoid biosynthesis,
Sesquiterpenoid and triterpenoid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
hopanoid biosynthesis (bacteria),
botryococcenes and methylated squalene biosynthesis,
4,4'-diapolycopenedioate biosynthesis,
staphyloxanthin biosynthesis
BR49808 show the reaction diagram R00702 show the reaction diagram RXN-12263 show the reaction diagram 1080
    4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + ferrocytochrome b5 + oxygen + H+ = 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + ferricytochrome b5 + H2O cholesterol biosynthesis   cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
    RXN66-311 show the reaction diagram  
show all sequences5.3.3.5 cholestenol DELTA-isomerase 5alpha-cholesta-8,24-dien-3beta-ol = 5alpha-cholesta-7,24-dien-3beta-ol cholesterol biosynthesis Steroid biosynthesis,
Metabolic pathways
cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I
BS399747 show the reaction diagram R04804 show the reaction diagram RXN66-320 show the reaction diagram 4455
show all sequences1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase zymosterone + NADPH = zymosterol + NADP+ cholesterol biosynthesis   cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
BS374946 show the reaction diagram   RXN66-319 show the reaction diagram  
show all sequences1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase zymosterone + NADPH = zymosterol + NADP+ cholesterol biosynthesis   cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
BS374946 show the reaction diagram   RXN66-319 show the reaction diagram  
show all sequences5.4.99.7 Lanosterol synthase (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol cholesterol biosynthesis Steroid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
lanosterol biosynthesis BR254 show the reaction diagram R03199 show the reaction diagram LANOSTEROL-SYNTHASE-RXN show the reaction diagram 3027
show all sequences1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 3-dehydro-4-methylzymosterol + NADPH + CO2 cholesterol biosynthesis Steroid biosynthesis,
Metabolic pathways,
Biosynthesis of antibiotics
cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
BS422640 show the reaction diagram R07494 show the reaction diagram RXN66-313 show the reaction diagram  
    4,4-dimethylzymosterol + ferrocytochrome b5 + oxygen + H+ = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + ferricytochrome b5 + H2O cholesterol biosynthesis   cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
    RXN66-310 show the reaction diagram  
show all sequences1.3.1.72 DELTA24-sterol reductase 5alpha-cholest-7-en-3beta-ol + NADP+ = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+ cholesterol biosynthesis Steroid biosynthesis,
Metabolic pathways
cholesterol biosynthesis I BR29448 show the reaction diagram R05703 show the reaction diagram RXN66-321 show the reaction diagram  
    4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol + ferrocytochrome b5 + oxygen + H+ = 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + ferricytochrome b5 + H2O cholesterol biosynthesis   cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
    RXN66-316 show the reaction diagram  
    4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + ferrocytochrome b5 + oxygen + H+ = 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + ferricytochrome b5 + H2O cholesterol biosynthesis   cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
    RXN66-312 show the reaction diagram  
    4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol + ferrocytochrome b5 + oxygen + H+ = 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + ferricytochrome b5 + H2O cholesterol biosynthesis   cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
    RXN66-317 show the reaction diagram  
show all sequences1.3.1.70 DELTA14-sterol reductase 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ cholesterol biosynthesis Steroid biosynthesis,
Metabolic pathways,
Biosynthesis of antibiotics
cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
BR29447 show the reaction diagram R05639 show the reaction diagram RXN66-306 show the reaction diagram  
    presqualene diphosphate + NADPH + H+ = squalene + diphosphate + NADP+ cholesterol biosynthesis Steroid biosynthesis,
Sesquiterpenoid and triterpenoid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
botryococcenes and methylated squalene biosynthesis BR48481 show the reaction diagram R02872 show the reaction diagram RXN-13724 show the reaction diagram,
RXN66-281 show the reaction diagram
 
show all sequences2.5.1.21 squalene synthase presqualene diphosphate + NADPH + H+ = squalene + diphosphate + NADP+ cholesterol biosynthesis Steroid biosynthesis,
Sesquiterpenoid and triterpenoid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
botryococcenes and methylated squalene biosynthesis BR48481 show the reaction diagram R02872 show the reaction diagram RXN-13724 show the reaction diagram,
RXN66-281 show the reaction diagram
 
show all sequences1.3.1.96 Botryococcus squalene synthase presqualene diphosphate + NADPH + H+ = squalene + diphosphate + NADP+ cholesterol biosynthesis Steroid biosynthesis,
Sesquiterpenoid and triterpenoid biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
botryococcenes and methylated squalene biosynthesis BR48481 show the reaction diagram R02872 show the reaction diagram RXN-13724 show the reaction diagram,
RXN66-281 show the reaction diagram
 
show all sequences1.3.1.21 7-dehydrocholesterol reductase cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ cholesterol biosynthesis Steroid biosynthesis,
Metabolic pathways
cholesterol biosynthesis II (via 24,25-dihydrolanosterol),
cholesterol biosynthesis I
BR33764 show the reaction diagram R01456 show the reaction diagram RXN66-323 show the reaction diagram 1634
show all sequences1.14.13.70 sterol 14alpha-demethylase lanosterol + 2 O2 + NADPH + H+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + NADP+ + 2 H2O cholesterol biosynthesis Steroid biosynthesis,
Metabolic pathways,
Biosynthesis of antibiotics
zymosterol biosynthesis BS186735 show the reaction diagram,
BS409746 show the reaction diagram
R05640 show the reaction diagram RXN3O-130 show the reaction diagram  
show all sequences1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 5alpha-cholesta-8,24-dien-3-one + NADPH + CO2 cholesterol biosynthesis   cholesterol biosynthesis III (via desmosterol),
cholesterol biosynthesis I,
zymosterol biosynthesis
BS422642 show the reaction diagram   RXN66-318 show the reaction diagram