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histidine metabolism (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences2.6.1.39 2-aminoadipate transaminase L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine histidine metabolism   L-histidine degradation V BS353949 show the reaction diagram   RXN-7571 show the reaction diagram  
show all sequences2.6.1.44 alanine-glyoxylate transaminase L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine histidine metabolism   L-histidine degradation V BS353949 show the reaction diagram   RXN-7571 show the reaction diagram  
show all sequences2.6.1.58 phenylalanine(histidine) transaminase L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine histidine metabolism   L-histidine degradation V BS353949 show the reaction diagram   RXN-7571 show the reaction diagram  
show all sequences2.6.1.64 glutamine-phenylpyruvate transaminase L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine histidine metabolism   L-histidine degradation V BS353949 show the reaction diagram   RXN-7571 show the reaction diagram  
show all sequences3.6.1.31 phosphoribosyl-ATP diphosphatase 1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR22771 show the reaction diagram R04035 show the reaction diagram HISTPRATPHYD-RXN show the reaction diagram  
    L-Histidinal + H2O + NAD+ <=> L-Histidine + NADH + H+ histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
L-histidine biosynthesis BS187855 show the reaction diagram R01163 show the reaction diagram HISTALDEHYD-RXN show the reaction diagram  
show all sequences1.1.1.23 histidinol dehydrogenase L-Histidinal + H2O + NAD+ <=> L-Histidine + NADH + H+ histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
L-histidine biosynthesis BS187855 show the reaction diagram R01163 show the reaction diagram HISTALDEHYD-RXN show the reaction diagram  
show all sequences4.3.1.3 histidine ammonia-lyase L-histidine = urocanate + NH3 histidine metabolism Histidine metabolism,
Metabolic pathways
L-histidine degradation III,
L-histidine degradation VI,
L-histidine degradation II,
L-histidine degradation I
BR3425 show the reaction diagram R01168 show the reaction diagram HISTIDINE-AMMONIA-LYASE-RXN show the reaction diagram 11319,
1406
show all sequences2.6.1.38 histidine transaminase L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate histidine metabolism Histidine metabolism imidazole-lactate degradation,
L-histidine degradation IV
BR47688 show the reaction diagram R01161 show the reaction diagram HISTTRANSAM-RXN show the reaction diagram  
show all sequences4.2.1.19 imidazoleglycerol-phosphate dehydratase D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR404 show the reaction diagram R03457 show the reaction diagram IMIDPHOSDEHYD-RXN show the reaction diagram  
show all sequences3.5.3.5 formimidoylaspartate deiminase N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3 histidine metabolism Histidine metabolism   BR22729 show the reaction diagram R03188 show the reaction diagram FORMIMINOASPARTATE-DEIMINASE-RXN show the reaction diagram  
show all sequences3.5.3.8 formimidoylglutamase N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide histidine metabolism Histidine metabolism,
Metabolic pathways
L-histidine degradation I BR26109 show the reaction diagram R02285 show the reaction diagram FORMIMINOGLUTAMASE-RXN show the reaction diagram  
show all sequences4.2.1.49 Urocanate hydratase 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O histidine metabolism Histidine metabolism,
Metabolic pathways
L-histidine degradation III,
L-histidine degradation VI,
L-histidine degradation II,
L-histidine degradation I
BR428 show the reaction diagram R02914 show the reaction diagram UROCANATE-HYDRATASE-RXN show the reaction diagram  
    L-histidinol + NAD+ = L-histidinal + NADH + H+ histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
L-histidine biosynthesis BS371011 show the reaction diagram R03012 show the reaction diagram HISTOLDEHYD-RXN show the reaction diagram  
show all sequences1.1.1.23 histidinol dehydrogenase L-histidinol + NAD+ = L-histidinal + NADH + H+ histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
L-histidine biosynthesis BS371011 show the reaction diagram R03012 show the reaction diagram HISTOLDEHYD-RXN show the reaction diagram  
show all sequences2.7.6.1 ribose-phosphate diphosphokinase ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate histidine metabolism Pentose phosphate pathway,
Purine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Biosynthesis of antibiotics,
Carbon metabolism,
Biosynthesis of amino acids
PRPP biosynthesis I BR47854 show the reaction diagram R01049 show the reaction diagram PRPPSYN-RXN show the reaction diagram 66
show all sequences5.3.1.16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR225 show the reaction diagram R04640 show the reaction diagram PRIBFAICARPISOM-RXN show the reaction diagram  
show all sequences6.1.1.21 histidine-tRNA ligase ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis histidine metabolism     BR52 show the reaction diagram      
show all sequences1.1.1.111 3-(imidazol-5-yl)lactate dehydrogenase (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+ histidine metabolism   imidazole-lactate degradation,
L-histidine degradation IV
BR29177 show the reaction diagram R04186 show the reaction diagram IMILACTDEHYDROG-RXN show the reaction diagram  
show all sequences1.14.13.5 imidazoleacetate 4-monooxygenase 4-imidazoleacetate + NADH + H+ + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O histidine metabolism Histidine metabolism   BR36766 show the reaction diagram R04066 show the reaction diagram IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN show the reaction diagram  
show all sequences2.4.2.17 ATP phosphoribosyltransferase 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR47479 show the reaction diagram R01071 show the reaction diagram ATPPHOSPHORIBOSYLTRANS-RXN show the reaction diagram  
show all sequences2.6.1.9 histidinol-phosphate transaminase L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR47443 show the reaction diagram R03243 show the reaction diagram HISTAMINOTRANS-RXN show the reaction diagram 3064
show all sequences3.1.3.15 histidinol-phosphatase L-histidinol phosphate + H2O = L-histidinol + phosphate histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR19199 show the reaction diagram R03013 show the reaction diagram HISTIDPHOS-RXN show the reaction diagram  
show all sequences3.5.4.9 methenyltetrahydrofolate cyclohydrolase 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate reductive acetyl coenzyme A pathway,
histidine metabolism
One carbon pool by folate,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
formaldehyde oxidation VII (THF pathway),
formate assimilation into 5,10-methylenetetrahydrofolate,
N10-formyl-tetrahydrofolate biosynthesis,
folate transformations I,
folate transformations II,
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate,
purine nucleobases degradation I (anaerobic),
purine nucleobases degradation II (anaerobic),
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria),
L-histidine degradation III
BR22746 show the reaction diagram R01655 show the reaction diagram METHENYLTHFCYCLOHYDRO-RXN show the reaction diagram 74
show all sequences3.5.1.15 aspartoacylase N-formyl-L-aspartate + H2O = formate + L-aspartate histidine metabolism Histidine metabolism,
Glyoxylate and dicarboxylate metabolism
  BR22713 show the reaction diagram R00526 show the reaction diagram FORMYLASPARTATE-DEFORMYLASE-RXN show the reaction diagram  
show all sequences3.5.1.8 formylaspartate deformylase N-formyl-L-aspartate + H2O = formate + L-aspartate histidine metabolism Histidine metabolism,
Glyoxylate and dicarboxylate metabolism
  BR22713 show the reaction diagram R00526 show the reaction diagram FORMYLASPARTATE-DEFORMYLASE-RXN show the reaction diagram  
4.1.3.-   N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR51141 show the reaction diagram R04558 show the reaction diagram GLUTAMIDOTRANS-RXN show the reaction diagram 4234
show all sequences4.3.1.B2 imidazole glycerol phosphate synthase N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR51141 show the reaction diagram R04558 show the reaction diagram GLUTAMIDOTRANS-RXN show the reaction diagram 4234
4.3.2.M2   N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR51141 show the reaction diagram R04558 show the reaction diagram GLUTAMIDOTRANS-RXN show the reaction diagram 4234
2.4.2.-   N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR51141 show the reaction diagram R04558 show the reaction diagram GLUTAMIDOTRANS-RXN show the reaction diagram 4234
    N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR51141 show the reaction diagram R04558 show the reaction diagram GLUTAMIDOTRANS-RXN show the reaction diagram 4234
show all sequences3.5.2.7 imidazolonepropionase (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+ histidine metabolism Histidine metabolism,
Metabolic pathways
L-histidine degradation III,
L-histidine degradation VI,
L-histidine degradation II,
L-histidine degradation I
BR19259 show the reaction diagram R02288 show the reaction diagram IMIDAZOLONEPROPIONASE-RXN show the reaction diagram  
show all sequences3.5.1.68 N-formylglutamate deformylase N-formyl-L-glutamate + H2O = formate + L-glutamate histidine metabolism Histidine metabolism,
Glyoxylate and dicarboxylate metabolism
L-histidine degradation II BR22707 show the reaction diagram R00525 show the reaction diagram N-FORMYLGLUTAMATE-DEFORMYLASE-RXN show the reaction diagram  
show all sequences4.1.1.22 histidine decarboxylase L-histidine = histamine + CO2 histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
histamine biosynthesis BR283 show the reaction diagram R01167 show the reaction diagram HISTIDINE-DECARBOXYLASE-RXN show the reaction diagram 1405
show all sequences4.1.1.28 aromatic-L-amino-acid decarboxylase L-histidine = histamine + CO2 histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
histamine biosynthesis BR283 show the reaction diagram R01167 show the reaction diagram HISTIDINE-DECARBOXYLASE-RXN show the reaction diagram 1405
show all sequences2.1.2.5 glutamate formimidoyltransferase 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate histidine metabolism Histidine metabolism,
One carbon pool by folate,
Metabolic pathways
  BR43944 show the reaction diagram R02287 show the reaction diagram   2252
show all sequences3.5.3.13 formimidoylglutamate deiminase N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3 histidine metabolism Histidine metabolism L-histidine degradation II BR22723 show the reaction diagram R02286 show the reaction diagram FORMIMINOGLUTAMATE-DEIMINASE-RXN show the reaction diagram 2251
show all sequences1.2.1.3 aldehyde dehydrogenase (NAD+) Imidazole-4-acetaldehyde + NAD+ + H2O <=> Imidazole-4-acetate + NADH + H+ histidine metabolism Histidine metabolism histamine degradation   R04065 show the reaction diagram RXN-10089 show the reaction diagram 3798
3.5.2.-   N-Formimino-L-aspartate <=> 4-Imidazolone-5-acetate + H2O histidine metabolism Histidine metabolism     R04214 show the reaction diagram    
show all sequences4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3 purine metabolism,
histidine metabolism
One carbon pool by folate,
Metabolic pathways
L-histidine degradation III,
purine nucleobases degradation II (anaerobic),
purine nucleobases degradation I (anaerobic)
BR3426 show the reaction diagram R02302 show the reaction diagram 4.3.1.4-RXN show the reaction diagram 2264
SPONTANEOUS   2-Oxoglutarate + Ammonia <=> 4-Oxoglutaramate + H2O histidine metabolism Histidine metabolism L-histidine degradation VI   R00270 show the reaction diagram RXN-7594 show the reaction diagram  
show all sequences3.5.4.19 phosphoribosyl-AMP cyclohydrolase 1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide histidine metabolism Histidine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-histidine biosynthesis BR26113 show the reaction diagram R04037 show the reaction diagram HISTCYCLOHYD-RXN show the reaction diagram