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BRENDA KEGG MetaCyc

bile acid biosynthesis, neutral pathway (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences1.14.14.23 cholesterol 7alpha-monooxygenase cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
  BR29138 show the reaction diagram R01463 show the reaction diagram    
show all sequences1.14.14.23 cholesterol 7alpha-monooxygenase cholesterol + reduced [NADPH-hemoprotein reductase] + oxygen = 7alpha-hydroxycholesterol + oxidized [NADPH-hemoprotein reductase] + H2O bile acid biosynthesis, neutral pathway   bile acid biosynthesis, neutral pathway     CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN show the reaction diagram  
show all sequences4.2.1.107 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O bile acid biosynthesis, neutral pathway   bile acid biosynthesis, neutral pathway BR48550 show the reaction diagram   4.2.1.107-RXN show the reaction diagram  
show all sequences1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase 7alpha-hydroxy-4-cholesten-3-one + NADPH = (5beta,7alpha)-7-hydroxycholestan-3-one + NADP+ bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BS396107 show the reaction diagram R04817 show the reaction diagram RXN-9840 show the reaction diagram 4465
show all sequences1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) 5beta-cholestane-3alpha,7alpha-diol + NADP+ = 7alpha-hydroxy-5beta-cholestan-3-one + NADPH + H+ bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BS422688 show the reaction diagram R04819 show the reaction diagram RXN-9841 show the reaction diagram 4467
show all sequences1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) 5beta-cholestane-3alpha,7alpha-diol + NADP+ = 7alpha-hydroxy-5beta-cholestan-3-one + NADPH + H+ bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BS422688 show the reaction diagram R04819 show the reaction diagram RXN-9841 show the reaction diagram 4467
show all sequences1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADPH + H+ bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BS422687 show the reaction diagram R04825 show the reaction diagram RXN-9796 show the reaction diagram 4470
show all sequences1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADPH + H+ bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BS422687 show the reaction diagram R04825 show the reaction diagram RXN-9796 show the reaction diagram 4470
show all sequences1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP+ = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane + NADPH + H+ bile acid biosynthesis, neutral pathway     BS424621 show the reaction diagram      
show all sequences1.1.1.181 cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase cholest-5-ene-3beta,7alpha-diol + NAD+ = 7alpha-hydroxycholest-4-en-3-one + NADH + H+ bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BR29239 show the reaction diagram R04263 show the reaction diagram 1.1.1.181-RXN show the reaction diagram 9288
show all sequences5.1.99.4 alpha-Methylacyl-CoA racemase (25S)-trihydroxycoprostanoyl-CoA = (25R)-trihydroxycoprostanoyl-CoA bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BS390365 show the reaction diagram R08734 show the reaction diagram RXN-9797 show the reaction diagram 10542
    (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 oxidized adrenodoxin + 2 H2O bile acid biosynthesis, neutral pathway   bile acid biosynthesis, neutral pathway BR50218 show the reaction diagram,
BS257109 show the reaction diagram
R03507 show the reaction diagram CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN show the reaction diagram  
show all sequences1.14.15.15 cholestanetriol 26-monooxygenase (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 oxidized adrenodoxin + 2 H2O bile acid biosynthesis, neutral pathway   bile acid biosynthesis, neutral pathway BR50218 show the reaction diagram,
BS257109 show the reaction diagram
R03507 show the reaction diagram CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN show the reaction diagram  
show all sequences5.1.99.4 alpha-Methylacyl-CoA racemase (25R)-3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA <=> (25S)-3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway   R08739 show the reaction diagram RXN-9845 show the reaction diagram  
show all sequences1.14.13.95 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O bile acid biosynthesis, neutral pathway     BS375015 show the reaction diagram     4471
show all sequences1.14.18.8 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O bile acid biosynthesis, neutral pathway     BS375015 show the reaction diagram     4471
    3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al + NAD+ + H2O <=> 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate + NADH + H+ bile acid biosynthesis, neutral pathway       R03506 show the reaction diagram    
show all sequences3.5.1.24 choloylglycine hydrolase glycocholate + H2O = cholate + glycine bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acids degradation,
glycocholate metabolism (bacteria)
BR22684 show the reaction diagram R05835 show the reaction diagram CHOLOYLGLYCINE-HYDROLASE-RXN show the reaction diagram 5426
show all sequences1.14.15.15 cholestanetriol 26-monooxygenase 5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2 = 5beta-cholestane-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
  BS386164 show the reaction diagram R04806 show the reaction diagram    
1.1.1.-   (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl CoA + NAD+ = H+ + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5-beta-cholestanoyl CoA + NADH bile acid biosynthesis, neutral pathway   bile acid biosynthesis, neutral pathway     RXN-9799 show the reaction diagram  
    5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 oxidized adrenodoxin + H2O bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BR50217 show the reaction diagram,
BS288576 show the reaction diagram
R04807 show the reaction diagram CHOLESTANETRIOL-26-MONOOXYGENASE-RXN show the reaction diagram  
show all sequences1.14.15.15 cholestanetriol 26-monooxygenase 5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 oxidized adrenodoxin + H2O bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BR50217 show the reaction diagram,
BS288576 show the reaction diagram
R04807 show the reaction diagram CHOLESTANETRIOL-26-MONOOXYGENASE-RXN show the reaction diagram  
show all sequences1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase 7alpha,12alpha-dihydroxy-4-cholesten-3-one + NADPH = 7alpha,12alpha-dihydroxy-5-beta-cholestan-3-one + NADP+ bile acid biosynthesis, neutral pathway Primary bile acid biosynthesis,
Metabolic pathways
bile acid biosynthesis, neutral pathway BS258371 show the reaction diagram R04823 show the reaction diagram RXN-9794 show the reaction diagram 4468