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BRENDA KEGG MetaCyc

proline metabolism (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences1.2.1.3 aldehyde dehydrogenase (NAD+) (S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+ proline metabolism Alanine, aspartate and glutamate metabolism,
Arginine and proline metabolism,
Metabolic pathways
  BS259182 show the reaction diagram R00707 show the reaction diagram PYRROLINECARBDEHYDROG-RXN show the reaction diagram 1083
show all sequences1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase (S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+ proline metabolism Alanine, aspartate and glutamate metabolism,
Arginine and proline metabolism,
Metabolic pathways
  BS259182 show the reaction diagram R00707 show the reaction diagram PYRROLINECARBDEHYDROG-RXN show the reaction diagram 1083
    (S)-1-Pyrroline-5-carboxylate + NAD+ + 2 H2O <=> L-Glutamate + NADH + H+ proline metabolism Alanine, aspartate and glutamate metabolism,
Arginine and proline metabolism,
Metabolic pathways
  BS259182 show the reaction diagram R00707 show the reaction diagram PYRROLINECARBDEHYDROG-RXN show the reaction diagram 1083
1.5.-.-   L-proline + FAD + H2O = (S)-1-pyrroline-5-carboxylate + FADH2 proline metabolism Arginine and proline metabolism,
Carbapenem biosynthesis,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
  BS389060 show the reaction diagram R10507 show the reaction diagram    
show all sequences1.5.5.2 proline dehydrogenase L-proline + FAD + H2O = (S)-1-pyrroline-5-carboxylate + FADH2 proline metabolism Arginine and proline metabolism,
Carbapenem biosynthesis,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
  BS389060 show the reaction diagram R10507 show the reaction diagram    
show all sequences1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H] L-proline + NADP+ = 1-pyrroline-2-carboxylate + NADPH + H+ proline metabolism Arginine and proline metabolism trans-3-hydroxy-L-proline degradation,
L-proline biosynthesis IV
BR36888 show the reaction diagram R01249 show the reaction diagram PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN show the reaction diagram,
RXN-16268 show the reaction diagram
1469
show all sequences1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) L-proline + NADP+ = 1-pyrroline-2-carboxylate + NADPH + H+ proline metabolism Arginine and proline metabolism trans-3-hydroxy-L-proline degradation,
L-proline biosynthesis IV
BR36888 show the reaction diagram R01249 show the reaction diagram PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN show the reaction diagram,
RXN-16268 show the reaction diagram
1469
show all sequences1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H] L-proline + NADP+ = 1-pyrroline-2-carboxylate + NADPH + H+ proline metabolism Arginine and proline metabolism trans-3-hydroxy-L-proline degradation,
L-proline biosynthesis IV
BR36888 show the reaction diagram R01249 show the reaction diagram PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN show the reaction diagram,
RXN-16268 show the reaction diagram
1469
show all sequences1.5.1.2 pyrroline-5-carboxylate reductase L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+ proline metabolism Arginine and proline metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
L-proline biosynthesis III,
L-proline biosynthesis I,
L-ornithine degradation II (Stickland reaction),
L-arginine degradation VI (arginase 2 pathway),
L-proline biosynthesis II (from arginine)
BR36895 show the reaction diagram R01251 show the reaction diagram PYRROLINECARBREDUCT-RXN show the reaction diagram 1470
    H+ + L-glutamate + ATP + NADPH = ADP + L-glutamate-5-semialdehyde + NADP+ + phosphate arginine metabolism,
proline metabolism
        PROLINE-MULTI show the reaction diagram  
show all sequences1.2.1.41 glutamate-5-semialdehyde dehydrogenase L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH + H+ proline metabolism Arginine and proline metabolism,
Carbapenem biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
L-Ndelta-acetylornithine biosynthesis,
L-proline biosynthesis III,
L-citrulline biosynthesis,
L-proline biosynthesis I,
L-ornithine biosynthesis II
BR36782 show the reaction diagram R03313 show the reaction diagram GLUTSEMIALDEHYDROG-RXN show the reaction diagram 3127
show all sequences2.6.1.8 2,5-diaminovalerate transaminase 2,5-diaminopentanoate + 2-oxoglutarate = 5-amino-2-oxopentanoate + L-glutamate proline metabolism   L-proline biosynthesis IV BR47495 show the reaction diagram,
BS354658 show the reaction diagram
R03248 show the reaction diagram 25-DIAMINOVALERATE-AMINOTRANSFERASE-RXN show the reaction diagram  
show all sequences1.5.99.B2 proline dehydrogenase (acceptor) L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor proline metabolism     BR51015 show the reaction diagram      
SPONTANEOUS   5-Amino-2-oxopentanoic acid <=> 1-Pyrroline-2-carboxylate + H2O proline metabolism Arginine and proline metabolism,
D-Arginine and D-ornithine metabolism
L-proline biosynthesis IV   R03249 show the reaction diagram RXN-6861 show the reaction diagram  
show all sequences5.1.1.4 proline racemase L-proline = D-proline proline metabolism Arginine and proline metabolism,
Metabolic pathways
L-ornithine degradation II (Stickland reaction) BR172 show the reaction diagram R01255 show the reaction diagram PROLINE-RACEMASE-RXN show the reaction diagram 1473
show all sequences5.1.1.8 4-hydroxyproline epimerase L-proline = D-proline proline metabolism Arginine and proline metabolism,
Metabolic pathways
L-ornithine degradation II (Stickland reaction) BR172 show the reaction diagram R01255 show the reaction diagram PROLINE-RACEMASE-RXN show the reaction diagram 1473
show all sequences6.1.1.15 proline-tRNA ligase ATP + L-Proline + tRNA(Pro) <=> AMP + Diphosphate + L-Prolyl-tRNA(Pro) proline metabolism Aminoacyl-tRNA biosynthesis     R03661 show the reaction diagram    
show all sequences6.1.1.15 proline-tRNA ligase ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro proline metabolism     BR45 show the reaction diagram      
    L-Glutamate 5-semialdehyde <=> (S)-1-Pyrroline-5-carboxylate + H2O proline metabolism Arginine and proline metabolism,
Carbapenem biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
indolmycin biosynthesis,
L-Ndelta-acetylornithine biosynthesis,
L-proline biosynthesis III,
L-citrulline biosynthesis,
L-proline biosynthesis I,
L-proline degradation,
ethylene biosynthesis II (microbes),
L-ornithine degradation II (Stickland reaction),
L-arginine degradation VI (arginase 2 pathway),
L-proline biosynthesis II (from arginine)
  R03314 show the reaction diagram SPONTPRO-RXN show the reaction diagram  
show all sequences3.5.1.20 citrullinase L-citrulline + H2O = L-ornithine + CO2 + NH3 proline metabolism   L-proline biosynthesis II (from arginine) BR19238 show the reaction diagram,
BS116217 show the reaction diagram
R00665 show the reaction diagram CITRULLINASE-RXN show the reaction diagram  
show all sequences2.7.2.11 glutamate 5-kinase ATP + L-glutamate = ADP + L-glutamate 5-phosphate proline metabolism Arginine and proline metabolism,
Carbapenem biosynthesis,
Metabolic pathways,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
L-Ndelta-acetylornithine biosynthesis,
L-proline biosynthesis III,
L-citrulline biosynthesis,
L-proline biosynthesis I,
L-ornithine biosynthesis II
BR47821 show the reaction diagram R00239 show the reaction diagram GLUTKIN-RXN show the reaction diagram 752
1.21.4.-   H+ + D-proline + NADH = 5-aminopentanoate + NAD+ proline metabolism   L-ornithine degradation II (Stickland reaction)     PRDABST-RXN show the reaction diagram  
show all sequences1.21.4.1 D-proline reductase (dithiol) D-proline + NADH = 5-aminopentanoic acid + NAD+ proline metabolism     BS370299 show the reaction diagram      
show all sequences2.6.1.11 acetylornithine transaminase L-ornithine + 2-oxoglutarate = L-glutamate + (S)-2-amino-5-oxopentanoate proline metabolism Arginine and proline metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
L-Ndelta-acetylornithine biosynthesis,
L-proline biosynthesis III,
L-citrulline biosynthesis,
L-ornithine biosynthesis II,
L-arginine degradation I (arginase pathway),
L-ornithine degradation II (Stickland reaction),
L-arginine degradation VI (arginase 2 pathway),
L-proline biosynthesis II (from arginine)
BS380017 show the reaction diagram R00667 show the reaction diagram ORNITHINE-GLU-AMINOTRANSFERASE-RXN show the reaction diagram 1047
show all sequences2.6.1.13 ornithine aminotransferase L-ornithine + 2-oxoglutarate = L-glutamate + (S)-2-amino-5-oxopentanoate proline metabolism Arginine and proline metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
L-Ndelta-acetylornithine biosynthesis,
L-proline biosynthesis III,
L-citrulline biosynthesis,
L-ornithine biosynthesis II,
L-arginine degradation I (arginase pathway),
L-ornithine degradation II (Stickland reaction),
L-arginine degradation VI (arginase 2 pathway),
L-proline biosynthesis II (from arginine)
BS380017 show the reaction diagram R00667 show the reaction diagram ORNITHINE-GLU-AMINOTRANSFERASE-RXN show the reaction diagram 1047
show all sequences2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase L-ornithine + 2-oxoglutarate = L-glutamate + (S)-2-amino-5-oxopentanoate proline metabolism Arginine and proline metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics
L-Ndelta-acetylornithine biosynthesis,
L-proline biosynthesis III,
L-citrulline biosynthesis,
L-ornithine biosynthesis II,
L-arginine degradation I (arginase pathway),
L-ornithine degradation II (Stickland reaction),
L-arginine degradation VI (arginase 2 pathway),
L-proline biosynthesis II (from arginine)
BS380017 show the reaction diagram R00667 show the reaction diagram ORNITHINE-GLU-AMINOTRANSFERASE-RXN show the reaction diagram 1047