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methionine metabolism (BRENDA)

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EC Number Recommended Name Reaction BRENDA Pathway Name KEGG Pathway Name MetaCyc Pathway Name Reaction ID BRENDA Reaction ID KEGG Reaction ID MetaCyc Reaction ID SABIO-RK
show all sequences2.5.1.48 cystathionine gamma-synthase O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
homocysteine and cysteine interconversion,
L-methionine biosynthesis I,
L-cysteine biosynthesis VI (from L-methionine)
BR47465 show the reaction diagram R02508 show the reaction diagram,
R03260 show the reaction diagram
O-SUCCHOMOSERLYASE-RXN show the reaction diagram 3081
show all sequences4.4.1.21 S-ribosylhomocysteine lyase S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of amino acids
L-cysteine biosynthesis VI (from L-methionine),
autoinducer AI-2 biosynthesis II (Vibrio),
autoinducer AI-2 biosynthesis I,
S-adenosyl-L-methionine cycle I
BR48539 show the reaction diagram,
BS371157 show the reaction diagram
R01291 show the reaction diagram RIBOSYLHOMOCYSTEINASE-RXN show the reaction diagram 6873
show all sequences2.1.1.37 DNA (cytosine-5-)-methyltransferase S-Adenosyl-L-methionine + DNA <=> S-Adenosyl-L-homocysteine + DNA 5-methylcytosine methionine metabolism       R00380 show the reaction diagram    
show all sequences2.1.1.37 DNA (cytosine-5-)-methyltransferase S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine methionine metabolism     BS319681 show the reaction diagram      
show all sequences3.2.2.16 methylthioadenosine nucleosidase S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5'-thioadenosine degradation I,
S-methyl-5'-thioadenosine degradation IV
BR19228 show the reaction diagram R01401 show the reaction diagram METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN show the reaction diagram 1593
show all sequences3.2.2.9 adenosylhomocysteine nucleosidase S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5'-thioadenosine degradation I,
S-methyl-5'-thioadenosine degradation IV
BR19228 show the reaction diagram R01401 show the reaction diagram METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN show the reaction diagram 1593
2.5.1.-   O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate methionine metabolism   L-methionine biosynthesis II BS354338 show the reaction diagram   CYSPH-RXN show the reaction diagram 13007
show all sequences2.5.1.48 cystathionine gamma-synthase O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate methionine metabolism   L-methionine biosynthesis II BS354338 show the reaction diagram   CYSPH-RXN show the reaction diagram 13007
show all sequences1.8.4.14 L-methionine (R)-S-oxide reductase L-Methionine + Thioredoxin disulfide + H2O <=> L-Methionine (R)-S-oxide + Thioredoxin methionine metabolism       R07608 show the reaction diagram 1.8.4.14-RXN show the reaction diagram  
show all sequences1.8.4.12 peptide-methionine (R)-S-oxide reductase L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O methionine metabolism     BR48616 show the reaction diagram      
show all sequences3.3.1.1 adenosylhomocysteinase S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
L-methionine degradation I (to L-homocysteine),
S-adenosyl-L-methionine cycle II
BR16046 show the reaction diagram R00192 show the reaction diagram ADENOSYLHOMOCYSTEINASE-RXN show the reaction diagram 738,
8119
show all sequences2.1.1.5 betaine-homocysteine S-methyltransferase betaine + L-homocysteine = dimethylglycine + L-methionine methionine metabolism Glycine, serine and threonine metabolism,
Cysteine and methionine metabolism,
Metabolic pathways
glycine betaine degradation II (mammalian),
glycine betaine degradation I,
L-methionine salvage from L-homocysteine
BR40558 show the reaction diagram R02821 show the reaction diagram 2.1.1.5-RXN show the reaction diagram 2687
show all sequences3.1.3.77 acireductone synthase 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation BR48755 show the reaction diagram R07394 show the reaction diagram R83-RXN show the reaction diagram  
show all sequences3.1.3.87 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation BR48755 show the reaction diagram R07394 show the reaction diagram R83-RXN show the reaction diagram  
show all sequences5.3.1.23 S-methyl-5-thioribose-1-phosphate isomerase S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation,
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II
BR230 show the reaction diagram,
BS1040 show the reaction diagram
R04420 show the reaction diagram 5.3.1.23-RXN show the reaction diagram  
    4-methylthio-2-oxobutanoate = beta-methiopropanal + CO2 methionine metabolism   L-methionine degradation III BS1456 show the reaction diagram   RXN-7704 show the reaction diagram  
show all sequences4.1.1.43 phenylpyruvate decarboxylase 4-methylthio-2-oxobutanoate = beta-methiopropanal + CO2 methionine metabolism   L-methionine degradation III BS1456 show the reaction diagram   RXN-7704 show the reaction diagram  
show all sequences2.1.1.14 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
L-methionine biosynthesis I,
L-methionine biosynthesis II,
L-methionine biosynthesis III,
S-adenosyl-L-methionine cycle I,
S-adenosyl-L-methionine cycle II
BR40568 show the reaction diagram R04405 show the reaction diagram HOMOCYSMET-RXN show the reaction diagram  
show all sequences2.1.1.13 methionine synthase 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine methionine metabolism Cysteine and methionine metabolism,
One carbon pool by folate,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
  BR40552 show the reaction diagram R00946 show the reaction diagram   1260
show all sequences2.7.1.100 S-methyl-5-thioribose kinase ATP + S-methyl-5-thio-D-ribose = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5'-thioadenosine degradation I BR47714 show the reaction diagram,
BS356940 show the reaction diagram
R04143 show the reaction diagram 5-METHYLTHIORIBOSE-KINASE-RXN show the reaction diagram 3864
show all sequences4.2.1.22 cystathionine beta-synthase L-cystathionine + H2O = L-homocysteine + pyruvate + NH3 methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
  BR3446 show the reaction diagram R01286 show the reaction diagram CYSTATHIONINE-BETA-LYASE-RXN show the reaction diagram 1500,
1501
show all sequences4.4.1.1 cystathionine gamma-lyase L-cystathionine + H2O = L-homocysteine + pyruvate + NH3 methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
  BR3446 show the reaction diagram R01286 show the reaction diagram CYSTATHIONINE-BETA-LYASE-RXN show the reaction diagram 1500,
1501
show all sequences4.4.1.6 S-alkylcysteine lyase L-cystathionine + H2O = L-homocysteine + pyruvate + NH3 methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
  BR3446 show the reaction diagram R01286 show the reaction diagram CYSTATHIONINE-BETA-LYASE-RXN show the reaction diagram 1500,
1501
show all sequences4.4.1.8 cystathionine beta-lyase L-cystathionine + H2O = L-homocysteine + pyruvate + NH3 methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
  BR3446 show the reaction diagram R01286 show the reaction diagram CYSTATHIONINE-BETA-LYASE-RXN show the reaction diagram 1500,
1501
show all sequences3.2.2.9 adenosylhomocysteine nucleosidase S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of amino acids
L-cysteine biosynthesis VI (from L-methionine),
autoinducer AI-2 biosynthesis II (Vibrio),
autoinducer AI-2 biosynthesis I,
S-adenosyl-L-methionine cycle I
BR19231 show the reaction diagram R00194 show the reaction diagram ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN show the reaction diagram  
show all sequences2.5.1.B21 S-adenosyl-L-methionine hydroxide adenosyltransferase S-adenosyl-L-methionine + H2O = adenosine + L-methionine + H+ methionine metabolism     BR49470 show the reaction diagram      
show all sequences2.5.1.6 methionine adenosyltransferase ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
2'-deoxymugineic acid phytosiderophore biosynthesis,
S-adenosyl-L-methionine biosynthesis,
ethylene biosynthesis I (plants),
L-methionine degradation I (to L-homocysteine),
S-adenosyl-L-methionine cycle II
BR47590 show the reaction diagram R00177 show the reaction diagram S-ADENMETSYN-RXN show the reaction diagram 96
show all sequences1.1.1.1 alcohol dehydrogenase methionol + NAD+ = 3-methylthiopropanal + NADH + H+ methionine metabolism   L-methionine degradation III     RXN-7706 show the reaction diagram  
show all sequences4.4.1.11 methionine gamma-lyase L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate methionine metabolism Cysteine and methionine metabolism dimethyl sulfide biosynthesis from methionine BR3437 show the reaction diagram R00654 show the reaction diagram METHIONINE-GAMMA-LYASE-RXN show the reaction diagram 1038
2.1.1.-   S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
L-methionine biosynthesis II BS289526 show the reaction diagram,
BS419713 show the reaction diagram
R00650 show the reaction diagram HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN show the reaction diagram 1035
show all sequences2.1.1.10 homocysteine S-methyltransferase S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
L-methionine biosynthesis II BS289526 show the reaction diagram,
BS419713 show the reaction diagram
R00650 show the reaction diagram HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN show the reaction diagram 1035
show all sequences2.1.1.13 methionine synthase S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites
L-methionine biosynthesis II BS289526 show the reaction diagram,
BS419713 show the reaction diagram
R00650 show the reaction diagram HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN show the reaction diagram 1035
show all sequences1.13.11.54 acireductone dioxygenase [iron(II)-requiring] 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation BR48660 show the reaction diagram R07364 show the reaction diagram R147-RXN show the reaction diagram  
show all sequences3.1.3.77 acireductone synthase 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation BR48754 show the reaction diagram R07393 show the reaction diagram R82-RXN show the reaction diagram  
show all sequences5.3.2.5 2,3-diketo-5-methylthiopentyl-1-phosphate enolase 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation BR48754 show the reaction diagram R07393 show the reaction diagram R82-RXN show the reaction diagram  
show all sequences6.1.1.10 methionine-tRNA ligase ATP + L-Methionine + tRNA(Met) <=> AMP + Diphosphate + L-Methionyl-tRNA methionine metabolism Aminoacyl-tRNA biosynthesis tRNA charging   R03659 show the reaction diagram METHIONINE--TRNA-LIGASE-RXN show the reaction diagram  
show all sequences6.1.1.10 methionine-tRNA ligase ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet methionine metabolism     BR40 show the reaction diagram      
show all sequences2.6.1.15 glutamine-pyruvate transaminase alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate methionine metabolism   L-methionine degradation III BS353571 show the reaction diagram   RXN-7708 show the reaction diagram 11201
show all sequences2.6.1.28 tryptophan-phenylpyruvate transaminase alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate methionine metabolism   L-methionine degradation III BS353571 show the reaction diagram   RXN-7708 show the reaction diagram 11201
show all sequences2.6.1.57 aromatic-amino-acid transaminase alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate methionine metabolism   L-methionine degradation III BS353571 show the reaction diagram   RXN-7708 show the reaction diagram 11201
show all sequences2.5.1.43 nicotianamine synthase 3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine methionine metabolism   2'-deoxymugineic acid phytosiderophore biosynthesis,
L-nicotianamine biosynthesis
BR47667 show the reaction diagram R00075 show the reaction diagram 2.5.1.43-RXN show the reaction diagram  
show all sequences4.2.1.109 methylthioribulose 1-phosphate dehydratase S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O methionine metabolism Cysteine and methionine metabolism,
Metabolic pathways
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation BR48756 show the reaction diagram R07392 show the reaction diagram R145-RXN show the reaction diagram