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2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Pathways
6-hydroxymethyl-dihydropterin diphosphate biosynthesis (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate
: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis V (Pyrococcus),6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium),
6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia),
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)
; "show the reaction diagram")
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natural substrates
dihydroneopterin aldolase
7,8-dihydroneopterin = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde
; "show the reaction diagram")
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natural substrates
7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase
7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate
; "show the reaction diagram")
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natural substrates
7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase
7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate
; "show the reaction diagram")
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natural substrates
GTP cyclohydrolase I
GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate
; "show the reaction diagram")
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natural substrates
GTP cyclohydrolase IV
GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate
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natural substrates
7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-(beta-D-ribofuranosyl)aniline 5'-phosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphate
; "show the reaction diagram")
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natural substrates
7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate
; "show the reaction diagram")
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natural substrates
dihydroneopterin triphosphate diphosphatase
7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate
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natural substrates
GTP cyclohydrolase II
GTP + 4 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate
; "show the reaction diagram")
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: multi-step reactionnatural substrates, multi-step reaction
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one = 7,8-dihydroneopterin 3'-phosphate + H2O
; "show the reaction diagram")
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natural substrates
GTP cyclohydrolase I
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
: threo-tetrahydrobiopterin biosynthesis,erythro-tetrahydrobiopterin biosynthesis I,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium),
drosopterin and aurodrosopterin biosynthesis,
tetrahydromonapterin biosynthesis,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I,
preQ0 biosynthesis
; "show the reaction diagram")
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: four-step reaction (see R00428+R05046+R05048+R04639)natural substrates
dihydroneopterin triphosphate aldolase
7,8-dihydroneopterin 3'-triphosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate
; "show the reaction diagram")
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natural substrates
dihydroneopterin phosphate aldolase
7,8-dihydroneopterin 3'-phosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde phosphate
; "show the reaction diagram")
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natural substrates