acetyl-CoA hydrolase
Pathways
acetate fermentation (BRENDA)






EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
(S)-methylmalonyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
ADP-dependent short-chain-acyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
acyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
4-hydroxybenzoyl-CoA thioesterase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
phenylacetyl-CoA hydrolase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
fluoroacetyl-CoA thioesterase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
acetyl-CoA C-acyltransferase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
carboxymethylproline synthase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
homoserine O-acetyltransferase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
hydroxymethylglutaryl-CoA synthase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
2-isopropylmalate synthase
acetyl-CoA + H2O = CoA + acetate
-
-
-
-
natural substrates
pyruvate dehydrogenase (NADP+)
pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+
-
-
-
-
natural substrates
acetate kinase
ATP + acetate = ADP + acetyl phosphate

Pyruvate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism

L-lysine fermentation to acetate and butanoate,
purine nucleobases degradation I (anaerobic),
(S)-lactate fermentation to propanoate, acetate and hydrogen,
acetate and ATP formation from acetyl-CoA I,
glycine degradation (reductive Stickland reaction),
ethanolamine utilization,
methanogenesis from acetate,
Bifidobacterium shunt,
purine nucleobases degradation II (anaerobic),
superpathway of fermentation (Chlamydomonas reinhardtii),
mixed acid fermentation,
pyruvate fermentation to acetate IV,
acetylene degradation (anaerobic),
pyruvate fermentation to acetate II
-
-
-
-
natural substrates
propionate kinase
ATP + acetate = ADP + acetyl phosphate

Pyruvate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism

L-lysine fermentation to acetate and butanoate,
purine nucleobases degradation I (anaerobic),
(S)-lactate fermentation to propanoate, acetate and hydrogen,
acetate and ATP formation from acetyl-CoA I,
glycine degradation (reductive Stickland reaction),
ethanolamine utilization,
methanogenesis from acetate,
Bifidobacterium shunt,
purine nucleobases degradation II (anaerobic),
superpathway of fermentation (Chlamydomonas reinhardtii),
mixed acid fermentation,
pyruvate fermentation to acetate IV,
acetylene degradation (anaerobic),
pyruvate fermentation to acetate II
-
-
-
-
natural substrates
carbamate kinase
ATP + acetate = ADP + acetyl phosphate

Pyruvate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism

L-lysine fermentation to acetate and butanoate,
purine nucleobases degradation I (anaerobic),
(S)-lactate fermentation to propanoate, acetate and hydrogen,
acetate and ATP formation from acetyl-CoA I,
glycine degradation (reductive Stickland reaction),
ethanolamine utilization,
methanogenesis from acetate,
Bifidobacterium shunt,
purine nucleobases degradation II (anaerobic),
superpathway of fermentation (Chlamydomonas reinhardtii),
mixed acid fermentation,
pyruvate fermentation to acetate IV,
acetylene degradation (anaerobic),
pyruvate fermentation to acetate II
-
-
-
-
natural substrates
phosphoribosylglycinamide formyltransferase
ATP + acetate = ADP + acetyl phosphate

Pyruvate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism

L-lysine fermentation to acetate and butanoate,
purine nucleobases degradation I (anaerobic),
(S)-lactate fermentation to propanoate, acetate and hydrogen,
acetate and ATP formation from acetyl-CoA I,
glycine degradation (reductive Stickland reaction),
ethanolamine utilization,
methanogenesis from acetate,
Bifidobacterium shunt,
purine nucleobases degradation II (anaerobic),
superpathway of fermentation (Chlamydomonas reinhardtii),
mixed acid fermentation,
pyruvate fermentation to acetate IV,
acetylene degradation (anaerobic),
pyruvate fermentation to acetate II
-
-
-
-
natural substrates
phosphate butyryltransferase
acetyl-CoA + phosphate = CoA + acetyl phosphate

Pyruvate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism

L-lysine fermentation to acetate and butanoate,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
acetate and ATP formation from acetyl-CoA I,
ethanolamine utilization,
methanogenesis from acetate,
heterolactic fermentation,
purine nucleobases degradation II (anaerobic),
superpathway of fermentation (Chlamydomonas reinhardtii),
sulfolactate degradation II,
mixed acid fermentation,
sulfoacetaldehyde degradation I,
pyruvate fermentation to acetate IV,
acetylene degradation (anaerobic),
pyruvate fermentation to acetate II
-
-
-
-
natural substrates
phosphate propanoyltransferase
acetyl-CoA + phosphate = CoA + acetyl phosphate

Pyruvate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism

L-lysine fermentation to acetate and butanoate,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
acetate and ATP formation from acetyl-CoA I,
ethanolamine utilization,
methanogenesis from acetate,
heterolactic fermentation,
purine nucleobases degradation II (anaerobic),
superpathway of fermentation (Chlamydomonas reinhardtii),
sulfolactate degradation II,
mixed acid fermentation,
sulfoacetaldehyde degradation I,
pyruvate fermentation to acetate IV,
acetylene degradation (anaerobic),
pyruvate fermentation to acetate II
-
-
-
-
natural substrates
phosphate acetyltransferase
acetyl-CoA + phosphate = CoA + acetyl phosphate

Pyruvate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism

L-lysine fermentation to acetate and butanoate,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
acetate and ATP formation from acetyl-CoA I,
ethanolamine utilization,
methanogenesis from acetate,
heterolactic fermentation,
purine nucleobases degradation II (anaerobic),
superpathway of fermentation (Chlamydomonas reinhardtii),
sulfolactate degradation II,
mixed acid fermentation,
sulfoacetaldehyde degradation I,
pyruvate fermentation to acetate IV,
acetylene degradation (anaerobic),
pyruvate fermentation to acetate II
-
-
-
-
natural substrates
pyruvate synthase
pyruvate + CoA + oxidized ferredoxin = acetyl-CoA + CO2 + reduced ferredoxin + 2 H+

Citrate cycle (TCA cycle),
Pyruvate metabolism,
Butanoate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism

pyruvate fermentation to butanol I,
L-glutamate degradation VII (to butanoate),
L-alanine degradation V (oxidative Stickland reaction),
pyruvate fermentation to hexanol (engineered),
gluconeogenesis II (Methanobacterium thermoautotrophicum),
purine nucleobases degradation II (anaerobic),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
Entner-Doudoroff pathway II (non-phosphorylative),
isopropanol biosynthesis (engineered),
pyruvate fermentation to acetone,
pyruvate fermentation to acetate I,
pyruvate fermentation to ethanol III,
reductive monocarboxylic acid cycle,
pyruvate fermentation to acetate VII,
pyruvate fermentation to acetate VI,
pyruvate fermentation to acetate III
-
-
-
-
natural substrates, generic, protein
2-oxoacid oxidoreductase (ferredoxin)
pyruvate + CoA + oxidized ferredoxin = acetyl-CoA + CO2 + reduced ferredoxin + 2 H+

Citrate cycle (TCA cycle),
Pyruvate metabolism,
Butanoate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism

pyruvate fermentation to butanol I,
L-glutamate degradation VII (to butanoate),
L-alanine degradation V (oxidative Stickland reaction),
pyruvate fermentation to hexanol (engineered),
gluconeogenesis II (Methanobacterium thermoautotrophicum),
purine nucleobases degradation II (anaerobic),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
Entner-Doudoroff pathway II (non-phosphorylative),
isopropanol biosynthesis (engineered),
pyruvate fermentation to acetone,
pyruvate fermentation to acetate I,
pyruvate fermentation to ethanol III,
reductive monocarboxylic acid cycle,
pyruvate fermentation to acetate VII,
pyruvate fermentation to acetate VI,
pyruvate fermentation to acetate III
-
-
-
-
natural substrates, generic, protein
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
pyruvate + CoA + oxidized ferredoxin = acetyl-CoA + CO2 + reduced ferredoxin + 2 H+

Citrate cycle (TCA cycle),
Pyruvate metabolism,
Butanoate metabolism,
Methane metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism

pyruvate fermentation to butanol I,
L-glutamate degradation VII (to butanoate),
L-alanine degradation V (oxidative Stickland reaction),
pyruvate fermentation to hexanol (engineered),
gluconeogenesis II (Methanobacterium thermoautotrophicum),
purine nucleobases degradation II (anaerobic),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
Entner-Doudoroff pathway II (non-phosphorylative),
isopropanol biosynthesis (engineered),
pyruvate fermentation to acetone,
pyruvate fermentation to acetate I,
pyruvate fermentation to ethanol III,
reductive monocarboxylic acid cycle,
pyruvate fermentation to acetate VII,
pyruvate fermentation to acetate VI,
pyruvate fermentation to acetate III
-
-
-
-
natural substrates, generic, protein
acetate-CoA ligase
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
-
-
-

natural substrates
propionate-CoA ligase
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
-
-
-

natural substrates
3-hydroxypropionyl-CoA synthase
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
-
-
-

natural substrates
acetaldehyde + NADP+ + H2O = acetate + NADPH + H+
-
-
-

natural substrates
aminobutyraldehyde dehydrogenase
acetaldehyde + NADP+ + H2O = acetate + NADPH + H+
-
-
-

natural substrates
succinate-semialdehyde dehydrogenase (NAD+)
acetaldehyde + NADP+ + H2O = acetate + NADPH + H+
-
-
-

natural substrates
2,5-dioxovalerate dehydrogenase
acetaldehyde + NADP+ + H2O = acetate + NADPH + H+
-
-
-

natural substrates
aldehyde dehydrogenase (NAD+)
acetaldehyde + NADP+ + H2O = acetate + NADPH + H+
-
-
-

natural substrates
aldehyde dehydrogenase (NADP+)
acetaldehyde + NADP+ + H2O = acetate + NADPH + H+
-
-
-

natural substrates
aldehyde dehydrogenase [NAD(P)+]
acetaldehyde + NADP+ + H2O = acetate + NADPH + H+
-
-
-

natural substrates
betaine-aldehyde dehydrogenase
acetaldehyde + NADP+ + H2O = acetate + NADPH + H+
-
-
-

natural substrates
L-glutamate gamma-semialdehyde dehydrogenase
acetaldehyde + NADP+ + H2O = acetate + NADPH + H+
-
-
-

natural substrates
pyruvate dehydrogenase (quinone)
pyruvate + ubiquinone + H2O = acetate + CO2 + ubiquinol
-
-
-

natural substrates
acylphosphatase
acetyl phosphate + H2O = acetate + phosphate
-
-
-
-
natural substrates
acid phosphatase
acetyl phosphate + H2O = acetate + phosphate
-
-
-
-
natural substrates
7.6.2.1
P-type phospholipid transporter
acetyl phosphate + H2O = acetate + phosphate
-
-
-
-
natural substrates