Pathways

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BRENDA KEGG MetaCyc

androgen and estrogen metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate-CoA ligase
ATP + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA = AMP + diphosphate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
BR51067 show the reaction diagram
R10769 show the reaction diagram
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natural substrates
4-hydroxy-2-oxohexanoate aldolase
(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
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natural substrates
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate
BR49990 show the reaction diagram
R09883 show the reaction diagram
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natural substrates
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
testosterone + NADP+ = androstenedione + NADPH + H+
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: NAD+ (see R01836)
natural substrates
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
testosterone + NADP+ = androstenedione + NADPH + H+
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: NAD+ (see R01836)
natural substrates
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
testosterone + NADP+ = androstenedione + NADPH + H+
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: NAD+ (see R01836)
natural substrates
pregnenolone + NAD+ = progesterone + NADH + H+
R02216 show the reaction diagram
2188
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: 3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4-isomerase two-step reaction
natural substrates
3beta-hydroxy-DELTA5-steroid dehydrogenase
pregnenolone + NAD+ = progesterone + NADH + H+
R02216 show the reaction diagram
2188
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: 3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4-isomerase two-step reaction
natural substrates
3(or 17)beta-hydroxysteroid dehydrogenase
pregnenolone + NAD+ = progesterone + NADH + H+
R02216 show the reaction diagram
2188
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: 3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4-isomerase two-step reaction
natural substrates
steroid DELTA-isomerase
pregnenolone + NAD+ = progesterone + NADH + H+
R02216 show the reaction diagram
2188
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: 3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4-isomerase two-step reaction
natural substrates
17alpha-hydroxyprogesterone deacetylase
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 = androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O
BR362 show the reaction diagram
R08518 show the reaction diagram
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: 17alpha-hydroxylase/17,20-lyase
natural substrates, generic, protein
3beta(or 20alpha)-hydroxysteroid dehydrogenase
testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
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: NADP+ (see R01838)
natural substrates
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
testosterone + NAD+ = androst-4-ene-3,17-dione + NADH + H+
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: NADP+ (see R01838)
natural substrates
cholesterol monooxygenase (side-chain-cleaving)
cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin
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: three-step reaction (R01454+R04854+R03933 or R02723+R04855+R03933)
natural substrates
3-oxosteroid 1-dehydrogenase
4-androstene-3,17-dione + acceptor = 1,4-androstene-3,17-dione + reduced acceptor
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natural substrates, generic
3-ketosteroid 9alpha-monooxygenase
androsta-1,4-diene-3,17-dione + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
BR49974 show the reaction diagram
R09860 show the reaction diagram
generic compounds
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: subsequently R09885
natural substrates, generic, protein
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O
BR49866 show the reaction diagram
R09819 show the reaction diagram
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: FMN is re-reduced by NADH (see R05705)
natural substrates
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
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natural substrates