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BRENDA KEGG MetaCyc

arachidonic acid metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
arachidonate 12-lipoxygenase
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
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natural substrates
15-hydroxyicosatetraenoate dehydrogenase
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NADP+ = 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NADPH + H+
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natural substrates
leukotriene-C4 synthase
leukotriene C4 = leukotriene A4 + glutathione
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natural substrates
arachidonate 8-lipoxygenase
arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
BR40471 show the reaction diagram
R01594 show the reaction diagram
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natural substrates
leukotriene-C4 hydrolase
leukotriene C4 + H2O = leukotriene D4 + L-glutamate
BR49989 show the reaction diagram
R09875 show the reaction diagram
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natural substrates
prostaglandin-E synthase
5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O
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natural substrates
glutathione peroxidase
5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O
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natural substrates
membrane dipeptidase
leukotriene D4 + H2O = leukotriene E4
incomplete
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H5C2O2N1
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prostaglandin-E synthase
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
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natural substrates
carbonyl reductase (NADPH)
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
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natural substrates
prostaglandin-E2 9-reductase
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
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natural substrates
prostaglandin-E2 9-reductase
prostaglandin F2alpha + NADP+ = 15-ketoprostaglandin F2alpha + NADPH + H+
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15-hydroxyprostaglandin-D dehydrogenase (NADP+)
prostaglandin F2alpha + NADP+ = 15-ketoprostaglandin F2alpha + NADPH + H+
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15-hydroxyprostaglandin-I dehydrogenase (NADP+)
prostaglandin F2alpha + NADP+ = 15-ketoprostaglandin F2alpha + NADPH + H+
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linoleate 13S-lipoxygenase
arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
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natural substrates
arachidonate 15-lipoxygenase
arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
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natural substrates
Prostaglandin-D synthase
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
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natural substrates
prostaglandin-E synthase
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
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natural substrates
prostaglandin-I synthase
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
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natural substrates
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+
R02799 show the reaction diagram
7733
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natural substrates
prostaglandin-F synthase
prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+
R02799 show the reaction diagram
7733
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natural substrates
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+
R02799 show the reaction diagram
7733
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natural substrates
17beta-estradiol 17-dehydrogenase
prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+
R02799 show the reaction diagram
7733
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natural substrates
prostaglandin-I synthase
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
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natural substrates
soluble epoxide hydrolase
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O = (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
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natural substrates
hepoxilin-epoxide hydrolase
(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate
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natural substrates
soluble epoxide hydrolase
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O = (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
R07109 show the reaction diagram
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natural substrates
microsomal epoxide hydrolase
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O = (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
R07109 show the reaction diagram
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natural substrates