Pathways

Filter results:
BRENDA KEGG MetaCyc

arachidonic acid metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
13,14-dehydro-15-oxoprostaglandin 13-reductase
15-ketoprostaglandin E2 + NADPH + H+ = 13,14-dihydro-15-keto-prostaglandin E2 + NADP+
-
-
-
-
natural substrates
15-hydroxyprostaglandin dehydrogenase (NAD+)
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
-
natural substrates
prostaglandin-E2 9-reductase
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
-
-
-
natural substrates
thromboxane-A synthase
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate
-
-
-
-
natural substrates
15-hydroxyprostaglandin dehydrogenase (NAD+)
prostaglandin F2alpha + NAD+ = 15-ketoprostaglandin F2alpha + NADH + H+
-
-
-
-
natural substrates
15-hydroxyprostaglandin-I dehydrogenase (NADP+)
prostaglandin F2alpha + NAD+ = 15-ketoprostaglandin F2alpha + NADH + H+
-
-
-
-
natural substrates
prostamide/prostaglandin F2alpha synthase
thioredoxin + (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13-dienoate = thioredoxin disulfide + (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dienoate
-
-
-
-
natural substrates
prostaglandin-E2 9-reductase
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+ = (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH + H+
-
-
-
-
natural substrates
15-hydroxyprostaglandin-D dehydrogenase (NADP+)
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+ = (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH + H+
-
-
-
-
natural substrates
15-hydroxyprostaglandin-D dehydrogenase (NADP+)
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
-
natural substrates
15-hydroxyprostaglandin-I dehydrogenase (NADP+)
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
-
natural substrates
arachidonate 12-lipoxygenase
arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
-
-
-
natural substrates
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NADP+ = 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NADPH + H+
-
-
-
-
natural substrates
15-hydroxyicosatetraenoate dehydrogenase
(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NADP+ = 15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NADPH + H+
-
-
-
-
natural substrates
arachidonate 5-lipoxygenase
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = leukotriene A4 + H2O
-
-
-
: second step of two-step reaction (R08527, R01595+R03058) following after R01595
: The product of the second reaction, (7E,9E,11Z,14Z)-(5S,6S)-5,6 epoxyicosa-7,9,11,14-tetraenoate, is leukotriene A(4).
natural substrates
arachidonate 8-lipoxygenase
arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
-
-
-
-
natural substrates
prostaglandin-E synthase
5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O
-
-
-
-
natural substrates
glutathione peroxidase
5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O
-
-
-
-
natural substrates
arachidonate 5-lipoxygenase
arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
-
-
-
: first step of two-step reaction (R08527, R01595+R03058) subsequently R03058
natural substrates
leukotriene-C4 hydrolase
leukotriene C4 + H2O = leukotriene D4 + L-glutamate
-
-
-
-
natural substrates
membrane dipeptidase
leukotriene D4 + H2O = leukotriene E4
incomplete
-
O2C2H5N1
-
-
prostaglandin-E synthase
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
-
natural substrates
carbonyl reductase (NADPH)
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
-
natural substrates
prostaglandin-E2 9-reductase
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
-
natural substrates
15-hydroxyprostaglandin dehydrogenase (NADP+)
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
-
-
-
natural substrates
prostaglandin-E2 9-reductase
prostaglandin F2alpha + NADP+ = 15-ketoprostaglandin F2alpha + NADPH + H+
-
-
-
-
-
15-hydroxyprostaglandin-D dehydrogenase (NADP+)
prostaglandin F2alpha + NADP+ = 15-ketoprostaglandin F2alpha + NADPH + H+
-
-
-
-
-
15-hydroxyprostaglandin-I dehydrogenase (NADP+)
prostaglandin F2alpha + NADP+ = 15-ketoprostaglandin F2alpha + NADPH + H+
-
-
-
-
-
prostaglandin-endoperoxide synthase
arachidonate + reduced acceptor + 2 O2 = prostaglandin H2 + acceptor + H2O
-
-
-
: multi-step reaction (dioxygenase x2 and peroxidase, see R01590+R00073)
natural substrates, multi-step reaction
linoleate 13S-lipoxygenase
arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
-
-
-
natural substrates
arachidonate 15-lipoxygenase
arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
-
-
-
natural substrates
Prostaglandin-D synthase
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
-
-
natural substrates
prostaglandin-E synthase
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
-
-
natural substrates
prostaglandin-I synthase
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
-
-
-
-
natural substrates
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+
-
-
-
-
natural substrates
prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+
-
-
-
-
natural substrates
prostaglandin-F synthase
prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+
-
-
-
-
natural substrates
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+
-
-
-
-
natural substrates
17beta-estradiol 17-dehydrogenase
prostaglandin D2 + NADPH + H+ = prostaglandin 9alpha,11beta-F2 + NADP+
-
-
-
-
natural substrates
prostaglandin-I synthase
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
-
-
-
-
natural substrates
soluble epoxide hydrolase
(10R)-hydroxy-(11S,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid + H2O = (10R,11R,12S)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoic acid
-
-
-
-
natural substrates
hepoxilin-epoxide hydrolase
(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate
-
-
-
-
natural substrates
hydroperoxy icosatetraenoate dehydratase
a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O
-
-
-
: general reaction
natural substrates
hydroperoxy icosatetraenoate isomerase
a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O
-
-
-
: general reaction
natural substrates
soluble epoxide hydrolase
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O = (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
-
-
-
-
natural substrates
microsomal epoxide hydrolase
(5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O = (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid
-
-
-
-
natural substrates