Pathways

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BRENDA KEGG MetaCyc

bile acid biosynthesis, neutral pathway (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
bile acid-CoA:amino acid N-acyltransferase
chenodeoxycholoyl-CoA + glycine = CoA + glycochenodeoxycholate
R08744 show the reaction diagram
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natural substrates
bile acid-CoA:amino acid N-acyltransferase
chenodeoxycholoyl-CoA + taurine = CoA + taurochenodeoxycholate
R08745 show the reaction diagram
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natural substrates
bile acid-CoA:amino acid N-acyltransferase
choloyl-CoA + taurine = CoA + taurocholate
R03720 show the reaction diagram
3481
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natural substrates
bile acid-CoA:amino acid N-acyltransferase
choloyl-CoA + glycine = CoA + glycocholate
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natural substrates
cholestanetriol 26-monooxygenase
5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2 = 5beta-cholestane-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O
R04806 show the reaction diagram
n.a.
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natural substrates, protein
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
5beta-cholestane-3alpha,7alpha-diol + NADP+ = 7alpha-hydroxy-5beta-cholestan-3-one + NADPH + H+
R04819 show the reaction diagram
4467
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: The enzyme acts on multiple 3α-hydroxysteroids. A-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.50, 3α-hydroxysteroid 3-dehydrogenase (B-specific).
natural substrates
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
5beta-cholestane-3alpha,7alpha-diol + NADP+ = 7alpha-hydroxy-5beta-cholestan-3-one + NADPH + H+
R04819 show the reaction diagram
4467
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: The enzyme acts on multiple 3α-hydroxysteroids. A-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.50, 3α-hydroxysteroid 3-dehydrogenase (B-specific).
natural substrates
3alpha,7alpha-Dihydroxy-5beta-cholestanate-CoA ligase
ATP + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA
BR80 show the reaction diagram, BS273 show the reaction diagram
R04507 show the reaction diagram, R08738 show the reaction diagram
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natural substrates
cholate-CoA ligase
ATP + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha-dihydroxy-5beta-cholestanoyl-CoA
BR80 show the reaction diagram, BS273 show the reaction diagram
R04507 show the reaction diagram, R08738 show the reaction diagram
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natural substrates
7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
7alpha-hydroxycholest-4-en-3-one + 2 ferrocytochrome b5 + 2 H+ + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + 2 ferricytochrome b5 + + H2O
BR48568 show the reaction diagram
n.a.
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natural substrates
DELTA4-3-oxosteroid 5beta-reductase
7alpha-hydroxy-4-cholesten-3-one + NADPH = (5beta,7alpha)-7-hydroxycholestan-3-one + NADP+
R04817 show the reaction diagram
4465
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natural substrates
cholesterol 7alpha-monooxygenase
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
BR29138 show the reaction diagram
R01463 show the reaction diagram
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natural substrates, generic, protein
3beta-hydroxy-DELTA5-steroid dehydrogenase
cholest-5-ene-3beta,7alpha-diol + NAD+ = 7alpha-hydroxycholest-4-en-3-one + NADH + H+
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: NADP+ ( see R04264)
natural substrates
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
cholest-5-ene-3beta,7alpha-diol + NAD+ = 7alpha-hydroxycholest-4-en-3-one + NADH + H+
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: NADP+ ( see R04264)
natural substrates
(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 oxidized adrenodoxin + 2 H2O
generic compounds
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natural substrates, generic
cholestanetriol 26-monooxygenase
(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 2 oxidized adrenodoxin + 2 H2O
generic compounds
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natural substrates, generic
cholestanetriol 26-monooxygenase
5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 oxidized adrenodoxin + H2O
generic compounds
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: Requires ferrodoxin. Acts on CHOLESTEROL, cholest-5-en-3α,7α-diol, 7α-hydroxycholest-4-en-3-one, 5β-cholestane-3α,7α-diol as well as 5-BETA-CHOLESTANE-3-ALPHA7-ALPHA12-ALP. With cholesterol as well as 26-hydroxycholesterol, 24-hydroxy- and 25-hydroxycholesterol are also formed. With prolonged treatment, 26-hydroxycholesterol is converted into the corresponding 27-aldehyde and 27-oic acid.
natural substrates, generic
5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 reduced adrenodoxin + 2 H+ + O2 = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + 2 oxidized adrenodoxin + H2O
generic compounds
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: Requires ferrodoxin. Acts on CHOLESTEROL, cholest-5-en-3α,7α-diol, 7α-hydroxycholest-4-en-3-one, 5β-cholestane-3α,7α-diol as well as 5-BETA-CHOLESTANE-3-ALPHA7-ALPHA12-ALP. With cholesterol as well as 26-hydroxycholesterol, 24-hydroxy- and 25-hydroxycholesterol are also formed. With prolonged treatment, 26-hydroxycholesterol is converted into the corresponding 27-aldehyde and 27-oic acid.
natural substrates, generic
alpha-methylacyl-CoA racemase
(25S)-trihydroxycoprostanoyl-CoA = (25R)-trihydroxycoprostanoyl-CoA
R08734 show the reaction diagram
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natural substrates
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADPH + H+
R04825 show the reaction diagram
4470
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: The enzyme acts on multiple 3α-hydroxysteroids. A-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.50, 3α-hydroxysteroid 3-dehydrogenase (B-specific).
natural substrates
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADPH + H+
R04825 show the reaction diagram
4470
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: The enzyme acts on multiple 3α-hydroxysteroids. A-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.50, 3α-hydroxysteroid 3-dehydrogenase (B-specific).
natural substrates
DELTA4-3-oxosteroid 5beta-reductase
7alpha,12alpha-dihydroxy-4-cholesten-3-one + NADPH = 7alpha,12alpha-dihydroxy-5-beta-cholestan-3-one + NADP+
R04823 show the reaction diagram
4468
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natural substrates
cholate-CoA ligase
ATP + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate + CoA = AMP + diphosphate + 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
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natural substrates
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O
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natural substrates
enoyl-CoA hydratase 2
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O
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natural substrates
acetyl-CoA C-acyltransferase
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA
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natural substrates
propanoyl-CoA C-acyltransferase
3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA
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natural substrates