Print
4-coumarate-CoA ligase
Pathways
ceramide biosynthesis (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis II (bacteria and plants),phosphatidylcholine acyl editing,
alkane biosynthesis II,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
sphingosine and sphingosine-1-phosphate metabolism,
sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (bacteria and plants),
stearate biosynthesis I (animals and fungi)
; "show the reaction diagram")
; "show the reaction diagram")
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: general reactionnatural substrates
long-chain-fatty-acid-CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis II (bacteria and plants),phosphatidylcholine acyl editing,
alkane biosynthesis II,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
sphingosine and sphingosine-1-phosphate metabolism,
sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (bacteria and plants),
stearate biosynthesis I (animals and fungi)
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: general reactionnatural substrates
phenylacetate-CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis II (bacteria and plants),phosphatidylcholine acyl editing,
alkane biosynthesis II,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
sphingosine and sphingosine-1-phosphate metabolism,
sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (bacteria and plants),
stearate biosynthesis I (animals and fungi)
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: general reactionnatural substrates
OPC-8:CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis II (bacteria and plants),phosphatidylcholine acyl editing,
alkane biosynthesis II,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
sphingosine and sphingosine-1-phosphate metabolism,
sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (bacteria and plants),
stearate biosynthesis I (animals and fungi)
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: general reactionnatural substrates
firefly luciferase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA
: stearate biosynthesis II (bacteria and plants),phosphatidylcholine acyl editing,
alkane biosynthesis II,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
sphingosine and sphingosine-1-phosphate metabolism,
sphingolipid recycling and degradation (yeast),
palmitate biosynthesis II (bacteria and plants),
stearate biosynthesis I (animals and fungi)
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: general reactionnatural substrates
3-dehydrosphinganine reductase
sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+
; "show the reaction diagram")
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natural substrates
serine C-palmitoyltransferase
palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2
; "show the reaction diagram")
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natural substrates
sphingosine N-acyltransferase
palmitoyl-CoA + sphinganine = CoA + dihydroceramide
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generic