4-coumarate-CoA ligase
Pathways
ceramide biosynthesis (BRENDA)






EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA

alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis (type II fatty acid synthase)
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-

natural substrates
long-chain-fatty-acid-CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA

alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis (type II fatty acid synthase)
-
-
-

natural substrates
phenylacetate-CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA

alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis (type II fatty acid synthase)
-
-
-

natural substrates
OPC-8:CoA ligase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA

alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis (type II fatty acid synthase)
-
-
-

natural substrates
firefly luciferase
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + a long-chain fatty acyl-CoA

alkane biosynthesis II,
phosphatidylcholine acyl editing,
wax esters biosynthesis II,
long chain fatty acid ester synthesis (engineered),
long-chain fatty acid activation,
stearate biosynthesis I (animals),
sphingosine and sphingosine-1-phosphate metabolism,
ceramide and sphingolipid recycling and degradation (yeast),
palmitate biosynthesis (type II fatty acid synthase)
-
-
-

natural substrates
3-dehydrosphinganine reductase
sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+
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natural substrates
serine C-palmitoyltransferase
palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2
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-
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natural substrates
sphingosine N-acyltransferase
palmitoyl-CoA + sphinganine = CoA + N-palmitoylsphinganine
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natural substrates
sphingoid base N-palmitoyltransferase
palmitoyl-CoA + sphinganine = CoA + N-palmitoylsphinganine
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natural substrates
very-long-chain ceramide synthase
palmitoyl-CoA + sphinganine = CoA + N-palmitoylsphinganine
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-
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natural substrates
ultra-long-chain ceramide synthase
palmitoyl-CoA + sphinganine = CoA + N-palmitoylsphinganine
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-
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natural substrates
sphingoid base N-stearoyltransferase
palmitoyl-CoA + sphinganine = CoA + N-palmitoylsphinganine
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-
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natural substrates