Pathways

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BRENDA KEGG MetaCyc

coenzyme M biosynthesis (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
formate:CoB-CoM heterodisulfide,ferredoxin reductase
2 CO2 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 formate + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
: coenzyme M biosynthesis
: Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: coenzyme B/coenzyme M regeneration V (formate-dependent)
: BR52242show the reaction diagram
: R11944show the reaction diagram
: RXN-18529show the reaction diagram
generic compounds
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natural substrates, generic, protein
H2:CoB-CoM heterodisulfide,ferredoxin reductase
2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 H2 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
: coenzyme M biosynthesis
: Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: coenzyme B/coenzyme M regeneration IV (H2-dependent)
: BR52241show the reaction diagram
: R11943show the reaction diagram
: RXN-18521show the reaction diagram
generic compounds
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natural substrates, generic, protein
coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
2 oxidized coenzyme F420 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H+ = 2 reduced coenzyme F420 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
: coenzyme M biosynthesis
: Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: coenzyme B/coenzyme M regeneration III (coenzyme F420-dependent)
: BR52240show the reaction diagram
: R11928show the reaction diagram
: RXN-18528show the reaction diagram
generic compounds
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natural substrates, generic, protein
L-2-hydroxycarboxylate dehydrogenase (NAD+)
(2R)-3-sulfolactate + NAD+ = 3-sulfopyruvate + NADH + H+
: coenzyme M biosynthesis
: Cysteine and methionine metabolism,
Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of cofactors
: (R)-cysteate degradation,
coenzyme M biosynthesis I
: BS419706show the reaction diagram
: R07136show the reaction diagram
: R230-RXNshow the reaction diagram, RXN-15670_WOPThis reaction also exists with phosphate.show the reaction diagram
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natural substrates
malate dehydrogenase
(2R)-3-sulfolactate + NAD+ = 3-sulfopyruvate + NADH + H+
: coenzyme M biosynthesis
: Cysteine and methionine metabolism,
Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of cofactors
: (R)-cysteate degradation,
coenzyme M biosynthesis I
: BS419706show the reaction diagram
: R07136show the reaction diagram
: R230-RXNshow the reaction diagram, RXN-15670_WOPThis reaction also exists with phosphate.show the reaction diagram
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natural substrates
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
(2R)-3-sulfolactate + NAD+ = 3-sulfopyruvate + NADH + H+
: coenzyme M biosynthesis
: Cysteine and methionine metabolism,
Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of cofactors
: (R)-cysteate degradation,
coenzyme M biosynthesis I
: BS419706show the reaction diagram
: R07136show the reaction diagram
: R230-RXNshow the reaction diagram, RXN-15670_WOPThis reaction also exists with phosphate.show the reaction diagram
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natural substrates
coenzyme-B sulfoethylthiotransferase
methyl-CoM + CoB = CoM-S-S-CoB + methane
: coenzyme M biosynthesis
: Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: methyl-coenzyme M reduction to methane
: BR36948show the reaction diagram
: R04541show the reaction diagram
: METHYL-COM-HTP-RXNshow the reaction diagram
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natural substrates
dihydromethanophenazine:CoB-CoM heterodisulfide reductase
CoB + CoM + methanophenazine = CoM-S-S-CoB + dihydromethanophenazine
: coenzyme M biosynthesis
: Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: coenzyme B/coenzyme M regeneration I (methanophenazine-dependent)
: BR47628show the reaction diagram
: R04540show the reaction diagram
: 1.8.98.1-RXNshow the reaction diagram
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natural substrates
2-phosphosulfolactate phosphatase
(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate
: coenzyme M biosynthesis
: Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of cofactors
: coenzyme M biosynthesis I
: BR36951show the reaction diagram
: R05789show the reaction diagram
: R229-RXNshow the reaction diagram
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natural substrates
(2R)-3-sulfolactate dehydrogenase (NADP+)
(2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+
: coenzyme M biosynthesis
: Cysteine and methionine metabolism,
Metabolic pathways
: sulfolactate degradation I
: BR50231show the reaction diagram
: R07137show the reaction diagram
: RXN-11690show the reaction diagram, RXN-15670show the reaction diagram
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natural substrates
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
(2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+
: coenzyme M biosynthesis
: Cysteine and methionine metabolism,
Metabolic pathways
: sulfolactate degradation I
: BR50231show the reaction diagram
: R07137show the reaction diagram
: RXN-11690show the reaction diagram, RXN-15670show the reaction diagram
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natural substrates
phosphosulfolactate synthase
(2R)-2-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite
: coenzyme M biosynthesis
: Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of cofactors
: coenzyme M biosynthesis I
: BR47587show the reaction diagram
: R07476show the reaction diagram
: 4.4.1.19-RXNshow the reaction diagram
: 12645
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natural substrates
sulfopyruvate decarboxylase
3-sulfopyruvate = 2-sulfoacetaldehyde + CO2
: coenzyme M biosynthesis
: Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of cofactors
: coenzyme M biosynthesis II,
sulfolactate degradation II,
coenzyme M biosynthesis I
: BR47974show the reaction diagram
: R05774show the reaction diagram
: R231-RXNshow the reaction diagram
: 5366
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: Requires thiamine diphosphate
natural substrates
phosphonopyruvate decarboxylase
3-sulfopyruvate = 2-sulfoacetaldehyde + CO2
: coenzyme M biosynthesis
: Methane metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Biosynthesis of cofactors
: coenzyme M biosynthesis II,
sulfolactate degradation II,
coenzyme M biosynthesis I
: BR47974show the reaction diagram
: R05774show the reaction diagram
: R231-RXNshow the reaction diagram
: 5366
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: Requires thiamine diphosphate
natural substrates
cysteate synthase
O-phospho-L-serine + sulfite = L-cysteate + phosphate
: coenzyme M biosynthesis
: coenzyme M biosynthesis II
: BR49121show the reaction diagram
: R09530show the reaction diagram
: RXN-11108show the reaction diagram
: 13216
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natural substrates
aspartate transaminase
L-cysteate + 2-oxoglutarate = 3-sulfopyruvate + L-glutamate
: coenzyme M biosynthesis
: Cysteine and methionine metabolism,
Metabolic pathways
: sulfolactate degradation III,
(R)-cysteate degradation,
coenzyme M biosynthesis II
: BS423733show the reaction diagram
: R02433show the reaction diagram
: RXN-11737show the reaction diagram
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: Evidence suggests that in mammals mitochondrial aspartate aminotransferase (EC 2.6.1.1) catalyzes this reaction in the degradation of PHE |CITS: [4623131] [16640556] [17442055]|. Some bacteria that degrade CPD-11799 possess a cysteate aminotransferase, which is presumed to be identical to EC 2.6.1.1 [19581363].
natural substrates