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Pathways

d-mannose degradation (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

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EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

2.6.1.102

GDP-perosamine synthase

GDP-alpha-D-perosamine + 2-oxoglutarate = GDP-4-dehydro-alpha-D-rhamnose + L-glutamate

: d-mannose degradation

: Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways

: GDP-D-perosamine biosynthesis

: BR50674

: R10460

: RXN-8953

natural substrates

5.3.1.8

mannose-6-phosphate isomerase

D-Mannose 6-phosphate = D-fructose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: 1,5-anhydrofructose degradation,
GDP-mannose biosynthesis,
beta-(1,4)-mannan degradation,
mannitol biosynthesis,
beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation,
D-mannose degradation,
mannitol degradation II

: BR239

: R00772

, R01819

: MANNPISOM-RXN

: 1124

natural substrates

5.3.1.9

glucose-6-phosphate isomerase

D-Mannose 6-phosphate = D-fructose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: BR239

: R00772

, R01819

: MANNPISOM-RXN

: 1124

natural substrates

3.2.1.114

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Manalpha1-3Man + H2O = alpha-mannose

: d-mannose degradation

: BS373784

incomplete

C6O6H12

3.2.1.24

alpha-mannosidase

Manalpha1-3Man + H2O = alpha-mannose

: d-mannose degradation

: BS373784

incomplete

C6O6H12

4.2.1.47

GDP-mannose 4,6-dehydratase

GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways

: GDP-mycosamine biosynthesis,
GDP-D-rhamnose biosynthesis,
GDP-L-fucose biosynthesis I (from GDP-D-mannose),
GDP-L-colitose biosynthesis,
GDP-D-perosamine biosynthesis,
GDP-6-deoxy-D-talose biosynthesis

: BR426

: R00888

: GDPMANDEHYDRA-RXN

: 588

natural substrates

5.4.2.10

phosphoglucosamine mutase

alpha-D-mannose 1-phosphate = D-mannose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: GDP-mannose biosynthesis,
beta-(1,4)-mannan degradation,
beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation

: BR24

, BS1189

: R01818

: PHOSMANMUT-RXN

: 69

: intermediate (see [CPD:C03693])

natural substrates

5.4.2.2

phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)

alpha-D-mannose 1-phosphate = D-mannose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: GDP-mannose biosynthesis,
beta-(1,4)-mannan degradation,
beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation

: BR24

, BS1189

: R01818

: PHOSMANMUT-RXN

: 69

: intermediate (see [CPD:C03693])

natural substrates

5.4.2.8

phosphomannomutase

alpha-D-mannose 1-phosphate = D-mannose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: GDP-mannose biosynthesis,
beta-(1,4)-mannan degradation,
beta-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation

: BR24

, BS1189

: R01818

: PHOSMANMUT-RXN

: 69

: intermediate (see [CPD:C03693])

natural substrates

3.6.1.-

GDP-mannose + H2O = GMP + D-mannose 1-phosphate

: d-mannose degradation

: Fructose and mannose metabolism

: BS141207

, BS430207

: R00881

: RXN0-5108

natural substrates

3.6.1.13

ADP-ribose diphosphatase

GDP-mannose + H2O = GMP + D-mannose 1-phosphate

: d-mannose degradation

: Fructose and mannose metabolism

: BS141207

, BS430207

: R00881

: RXN0-5108

natural substrates

3.6.1.21

ADP-sugar diphosphatase

GDP-mannose + H2O = GMP + D-mannose 1-phosphate

: d-mannose degradation

: Fructose and mannose metabolism

: BS141207

, BS430207

: R00881

: RXN0-5108

natural substrates

3.6.1.9

nucleotide diphosphatase

GDP-mannose + H2O = GMP + D-mannose 1-phosphate

: d-mannose degradation

: Fructose and mannose metabolism

: BS141207

, BS430207

: R00881

: RXN0-5108

natural substrates

2.7.7.13

mannose-1-phosphate guanylyltransferase

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: GDP-mannose biosynthesis

: BR47862

, BS358533

: R00885

: 2.7.7.13-RXN

: 15252, 587, 8539

natural substrates

2.7.7.28

nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: GDP-mannose biosynthesis

: BR47862

, BS358533

: R00885

: 2.7.7.13-RXN

: 15252, 587, 8539

natural substrates

2.7.7.30

fucose-1-phosphate guanylyltransferase

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: GDP-mannose biosynthesis

: BR47862

, BS358533

: R00885

: 2.7.7.13-RXN

: 15252, 587, 8539

natural substrates

2.7.7.34

glucose-1-phosphate guanylyltransferase

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
O-Antigen nucleotide sugar biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites

: GDP-mannose biosynthesis

: BR47862

, BS358533

: R00885

: 2.7.7.13-RXN

: 15252, 587, 8539

natural substrates

2.7.1.1

hexokinase

ATP + D-mannose = ADP + D-mannose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: 1,5-anhydrofructose degradation,
mannitol degradation II,
CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis

: BR47797

: R01326

: MANNKIN-RXN

: 575

natural substrates

2.7.1.2

glucokinase

ATP + D-mannose = ADP + D-mannose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: 1,5-anhydrofructose degradation,
mannitol degradation II,
CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis

: BR47797

: R01326

: MANNKIN-RXN

: 575

natural substrates

2.7.1.4

fructokinase

ATP + D-mannose = ADP + D-mannose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: 1,5-anhydrofructose degradation,
mannitol degradation II,
CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis

: BR47797

: R01326

: MANNKIN-RXN

: 575

natural substrates

2.7.1.55

allose kinase

ATP + D-mannose = ADP + D-mannose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: 1,5-anhydrofructose degradation,
mannitol degradation II,
CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis

: BR47797

: R01326

: MANNKIN-RXN

: 575

natural substrates

2.7.1.60

N-acylmannosamine kinase

ATP + D-mannose = ADP + D-mannose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: 1,5-anhydrofructose degradation,
mannitol degradation II,
CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis

: BR47797

: R01326

: MANNKIN-RXN

: 575

natural substrates

2.7.1.7

mannokinase

ATP + D-mannose = ADP + D-mannose 6-phosphate

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: 1,5-anhydrofructose degradation,
mannitol degradation II,
CMP-2-keto-3-deoxy-D-glycero-D-galacto-nononate biosynthesis

: BR47797

: R01326

: MANNKIN-RXN

: 575

natural substrates

2.7.7.22

mannose-1-phosphate guanylyltransferase (GDP)

GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: BR47869

, BS358463

: R00883

: MANNPGUANYLTRANGDP-RXN

: 9123

natural substrates

2.7.7.37

aldose-1-phosphate nucleotidyltransferase

GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: BR47869

, BS358463

: R00883

: MANNPGUANYLTRANGDP-RXN

: 9123

natural substrates

2.7.7.69

GDP-L-galactose phosphorylase

GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose

: d-mannose degradation

: Fructose and mannose metabolism,
Amino sugar and nucleotide sugar metabolism,
Metabolic pathways

: BR47869

, BS358463

: R00883

: MANNPGUANYLTRANGDP-RXN

: 9123

natural substrates