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tetracenomycin F2 synthase
Pathways
elloramycin biosynthesis (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O
; "show the reaction diagram")
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: multi-step reaction (see R06643+R09269+R09355)natural substrates, multi-step reaction
tetracenomycin F2 cyclase
tetracenomycin F2 = tetracenomycin F1 + H2O
; "show the reaction diagram")
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natural substrates
tetracenomycin-F1 monooxygenase
tetracenomycin F1 + O2 = tetracenomycin D3 + H2O
; "show the reaction diagram")
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natural substrates
tetracenomycin A2 monooxygenase-dioxygenase
tetracenomycin B2 + 2 O2 + 2 NADPH + 2 H+ = 8-demethyl tetracenomycin C + 2 NADP+ + H2O
; "show the reaction diagram")
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: It has been shown that the 4- and 12a-OH groups of the products are derived from two separate dioxygen molecules, while the 4a-OH group is derived from a water molecule [11009387]. Thus water is both used as a substrate and formed from molecular oxygen during catalysis.natural substrates
8-demethyltetracenomycin C L-rhamnosyltransferase
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C
; "show the reaction diagram")
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natural substrates
8-demethyl-8-alpha-L-rhamnosyl tetracenomycin-C 2'-O-methyltransferase
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
; "show the reaction diagram")
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natural substrates
8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
; "show the reaction diagram")
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natural substrates
8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
; "show the reaction diagram")
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natural substrates