Pathways

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BRENDA KEGG MetaCyc

glutamate and glutamine metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
asparaginyl-tRNA synthase (glutamine-hydrolysing)
ATP + L-glutamyl-tRNAGln + L-glutamine = ADP + phosphate + L-glutaminyl-tRNAGln + L-glutamate
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natural substrates
glutaminyl-tRNA synthase (glutamine-hydrolysing)
ATP + L-glutamyl-tRNAGln + L-glutamine = ADP + phosphate + L-glutaminyl-tRNAGln + L-glutamate
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natural substrates
4-aminobutyrate-2-oxoglutarate transaminase
4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine
BR50304 show the reaction diagram
R10178 show the reaction diagram
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natural substrates
(R)-3-amino-2-methylpropionate-pyruvate transaminase
4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine
BR50304 show the reaction diagram
R10178 show the reaction diagram
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natural substrates
isocitrate lyase
(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate
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: multi-step reaction (see R03153+R00237)
natural substrates, multi-step reaction
citramalate lyase
(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate
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: multi-step reaction (see R03153+R00237)
natural substrates, multi-step reaction
fumarate hydratase
(S)-2-Methylmalate = 2-methylfumarate + H2O
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natural substrates
(S)-2-methylmalate dehydratase
(S)-2-Methylmalate = 2-methylfumarate + H2O
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natural substrates
acyl-CoA dehydrogenase (NADP+)
crotonyl-CoA + reduced acceptor = butyryl-CoA + oxidized acceptor
generic compounds
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natural substrates, generic
short-chain acyl-CoA dehydrogenase
crotonyl-CoA + reduced acceptor = butyryl-CoA + oxidized acceptor
generic compounds
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natural substrates, generic
glutaconyl-CoA decarboxylase
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2
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: following after R10074 (ec 1.3.8.6) requires Na+ and acts as a sodium pump (ec 4.1.1.70)
natural substrates
glutaryl-CoA dehydrogenase (ETF)
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2
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: following after R10074 (ec 1.3.8.6) requires Na+ and acts as a sodium pump (ec 4.1.1.70)
natural substrates
methylcrotonoyl-CoA carboxylase
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2
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: following after R10074 (ec 1.3.8.6) requires Na+ and acts as a sodium pump (ec 4.1.1.70)
natural substrates
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2
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: following after R10074 (ec 1.3.8.6) requires Na+ and acts as a sodium pump (ec 4.1.1.70)
natural substrates
(R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O
BR51549 show the reaction diagram
R03937 show the reaction diagram
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natural substrates
(R)-2-hydroxyglutaryl-CoA dehydratase
(R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O
BR51549 show the reaction diagram
R03937 show the reaction diagram
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natural substrates
(R)-2-hydroxyglutaryl-CoA dehydratase
(R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O
BR51549 show the reaction diagram
R03937 show the reaction diagram
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natural substrates
aspartate ammonia-lyase
L-aspartate = fumarate + NH3
BR481 show the reaction diagram
R00490 show the reaction diagram
922
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natural substrates
methylaspartate ammonia-lyase
L-aspartate = fumarate + NH3
BR481 show the reaction diagram
R00490 show the reaction diagram
922
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natural substrates
N-methyl-2-oxoglutaramate hydrolase
2-oxoglutaramate + H2O = 2-oxoglutarate + NH3
BR50321 show the reaction diagram
R00269 show the reaction diagram
771
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natural substrates
glutamine-pyruvate transaminase
L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine
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natural substrates
serine-pyruvate transaminase
L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine
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natural substrates
asparaginase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
glutaminase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
glutamin-(asparagin-)ase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
peptidyl-glutaminase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
protein-glutamine glutaminase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
imidazole glycerol phosphate synthase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
imidazole glycerol-phosphate synthase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
CTP synthase (glutamine hydrolysing)
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
GMP synthase (glutamine-hydrolysing)
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
asparagine synthase (glutamine-hydrolysing)
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
carbamoyl-phosphate synthase (glutamine-hydrolysing)
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
glutaminyl-tRNA synthase (glutamine-hydrolysing)
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
tryptophanyl aminopeptidase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
gamma-glutamyltransferase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
amidophosphoribosyltransferase
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
glutamate synthase (NADPH)
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
glutamate synthase (ferredoxin)
L-glutamine + H2O = L-glutamate + NH3
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: the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor ec 6.3.5.4 (see R00578, R00256+R00483) ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
natural substrates
glutamate synthase (ferredoxin)
2 L-glutamate + oxidized ferredoxin = L-glutamine + 2-oxoglutarate + reduced ferredoxin + 2 H+
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: two-step reaction (see R00256+R10086)
natural substrates, generic, protein
2-oxoglutarate reductase
(R)-2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH + H+
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natural substrates
phosphoglycerate dehydrogenase
(R)-2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH + H+
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natural substrates
L-2-hydroxyglutarate dehydrogenase
(R)-2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH + H+
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natural substrates
glutaconate CoA-transferase
acetyl-CoA + (R)-2-hydroxyglutarate = acetate + (R)-2-hydroxyglutaryl-1-CoA
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natural substrates
glutamate-tRNA ligase
ATP + L-glutamate + tRNAGlx = AMP + diphosphate + glutamyl-tRNAGlx
BR44350 show the reaction diagram
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natural substrates, generic, nucleotide
glutamine-tRNA ligase
ATP + L-glutamate + tRNAGlx = AMP + diphosphate + glutamyl-tRNAGlx
BR44350 show the reaction diagram
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natural substrates, generic, nucleotide
glutamate-tRNAGln ligase
ATP + L-glutamate + tRNAGlx = AMP + diphosphate + glutamyl-tRNAGlx
BR44350 show the reaction diagram
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natural substrates, generic, nucleotide
lysine-tRNA ligase
ATP + L-glutamate + tRNAGlx = AMP + diphosphate + glutamyl-tRNAGlx
BR44350 show the reaction diagram
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natural substrates, generic, nucleotide
glutamyl-Q-tRNA(Asp) ligase
ATP + L-glutamate + tRNAGlx = AMP + diphosphate + glutamyl-tRNAGlx
BR44350 show the reaction diagram
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natural substrates, generic, nucleotide