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BRENDA KEGG MetaCyc

heme metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
hydrogen peroxide-dependent heme synthase
Fe-coproporphyrin III + 2 H2O2 = protoheme + 2 CO2 + 4 H2O
BR52578 show the reaction diagram
R11522 show the reaction diagram
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: coproheme decarboxylase
natural substrates
1.3.98.e
Fe-coproporphyrin III + 2 H2O2 = protoheme + 2 CO2 + 4 H2O
BR52578 show the reaction diagram
R11522 show the reaction diagram
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: coproheme decarboxylase
natural substrates
Fe-coproporphyrin III + 2 H2O2 = protoheme + 2 CO2 + 4 H2O
BR52578 show the reaction diagram
R11522 show the reaction diagram
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: coproheme decarboxylase
natural substrates
protoporphyrinogen IX dehydrogenase (menaquinone)
protoporphyrinogen IX + 3 menaquinone = protoporphyrin IX + 3 menaquinol
BR49166 show the reaction diagram
R09489 show the reaction diagram
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natural substrates
siroheme decarboxylase
siroheme = 12,18-didecarboxysiroheme + 2 CO2
BR51140 show the reaction diagram
R12000 show the reaction diagram
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natural substrates
heme oxygenase (biliverdin-producing)
protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O
BR40384 show the reaction diagram
R00311 show the reaction diagram
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: multi-step reaction
natural substrates, multi-step reaction, generic, protein
heme oxygenase (biliverdin-IX-beta and delta-forming)
protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O
BR40384 show the reaction diagram
R00311 show the reaction diagram
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: multi-step reaction
natural substrates, multi-step reaction, generic, protein
biliverdin reductase
bilirubin + NADP+ = biliverdin + NADPH + H+
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: NAD+ (see R02391)
natural substrates
coproporphyrinogen dehydrogenase
coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine
BR48612 show the reaction diagram
R06895 show the reaction diagram
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natural substrates
glutamate-1-semialdehyde 2,1-aminomutase
L-glutamate 1-semialdehyde = 5-aminolevulinate
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: multi-step reaction intermediate [(S)-4,5-diaminopentanoate]
natural substrates, multi-step reaction
glutamyl-tRNA reductase
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+
BR48497 show the reaction diagram
R04109 show the reaction diagram
9145
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natural substrates
histidinol-phosphate transaminase
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
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natural substrates
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2
BR49530 show the reaction diagram
R07238 show the reaction diagram
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: second step of two-step reaction (R03194, R07237+R07238), following after R07237
: This enzyme catalyzes two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2. It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III. The second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76) and the third step involves the chelation of Fe(2+) to sirohydrochlorin to form siroheme (EC 4.99.1.4). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction. Also involved in the biosynthesis of cobalamin.
natural substrates
uroporphyrinogen-III C-methyltransferase
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2
BR49530 show the reaction diagram
R07238 show the reaction diagram
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: second step of two-step reaction (R03194, R07237+R07238), following after R07237
: This enzyme catalyzes two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2. It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III. The second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76) and the third step involves the chelation of Fe(2+) to sirohydrochlorin to form siroheme (EC 4.99.1.4). In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p. In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction. Also involved in the biosynthesis of cobalamin.
natural substrates
uroporphyrinogen-III C-methyltransferase
S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1
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: first step of two-step reaction (R03194, R07237+R07238), subsequently R07238
natural substrates
S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1
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: first step of two-step reaction (R03194, R07237+R07238), subsequently R07238
natural substrates
sirohydrochlorin cobaltochelatase
siroheme + 2 H+ = sirohydrochlorin + Fe2+
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: multifunctional enzyme: siroheme synthase: sirohydrochlorin ferrochelatase (R03194+R03947+R02864) following after R03947
natural substrates
sirohydrochlorin ferrochelatase
siroheme + 2 H+ = sirohydrochlorin + Fe2+
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: multifunctional enzyme: siroheme synthase: sirohydrochlorin ferrochelatase (R03194+R03947+R02864) following after R03947
natural substrates
precorrin-2 dehydrogenase
precorrin-2 + NAD+ = sirohydrochlorin + NADH + H+
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: multifunctional enzyme: siroheme synthase: precorrin-2 dehydrogenase (R03194+R03947+R02864) following after R03194, subsequently R02864
natural substrates