Pathways

Filter results:
BRENDA KEGG MetaCyc

histidine metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
histidine decarboxylase
L-histidine = histamine + CO2
-
-
-
-
natural substrates
phenylalanine decarboxylase
L-histidine = histamine + CO2
-
-
-
-
natural substrates
L-Histidinal + H2O + NAD+ <=> L-Histidine + NADH + H+
-
-
-
: second step of two-step reaction (R01158, R03012+R01163) following after R03012
: This subreaction of RXN-8001 is physiologically irreversible per [8037463].
natural substrates
histidinol dehydrogenase
L-Histidinal + H2O + NAD+ <=> L-Histidine + NADH + H+
-
-
-
: second step of two-step reaction (R01158, R03012+R01163) following after R03012
: This subreaction of RXN-8001 is physiologically irreversible per [8037463].
natural substrates
L-histidinol + NAD+ = L-histidinal + NADH + H+
-
-
-
: first step of two-step reaction (R01158, R03012+R01163) subsequently R01163
: This subreaction of RXN-8001 is reversible per [8037463].
natural substrates
histidinol dehydrogenase
L-histidinol + NAD+ = L-histidinal + NADH + H+
-
-
-
: first step of two-step reaction (R01158, R03012+R01163) subsequently R01163
: This subreaction of RXN-8001 is reversible per [8037463].
natural substrates
histidinol-phosphatase
L-histidinol phosphate + H2O = L-histidinol + phosphate
-
-
-
-
natural substrates
acid phosphatase
L-histidinol phosphate + H2O = L-histidinol + phosphate
-
-
-
-
natural substrates
histidinol-phosphate transaminase
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
-
-
-
-
natural substrates
imidazoleglycerol-phosphate dehydratase
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
-
-
-
-
natural substrates
imidazole glycerol phosphate synthase
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
-
-
: two-step reaction (see R00256+R12152)
natural substrates
imidazole glycerol-phosphate synthase
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
-
-
: two-step reaction (see R00256+R12152)
natural substrates
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
-
-
-
: two-step reaction (see R00256+R12152)
natural substrates
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
-
-
-
-
natural substrates
ATP phosphoribosyltransferase
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
natural substrates
phosphoribosyl-ATP diphosphatase
1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate
-
-
-
-
natural substrates
phosphoribosyl-AMP cyclohydrolase
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
-
-
-
-
natural substrates
urocanate hydratase
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O
-
-
-
: multi-step reaction covalent intermediate with NAD+
natural substrates, multi-step reaction
formimidoylglutamase
N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide
-
-
-
-
natural substrates
glutamate formimidoyltransferase
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
BR43944 show the reaction diagram
R02287 show the reaction diagram
2252
-
-
-
-
natural substrates
formimidoylglutamate deiminase
N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3
-
-
-
-
natural substrates
N-formylglutamate deformylase
N-formyl-L-glutamate + H2O = formate + L-glutamate
-
-
-
-
natural substrates
formylaspartate deformylase
N-formyl-L-glutamate + H2O = formate + L-glutamate
-
-
-
-
natural substrates
aspartoacylase
N-formyl-L-aspartate + H2O = formate + L-aspartate
-
-
-
-
natural substrates
formylaspartate deformylase
N-formyl-L-aspartate + H2O = formate + L-aspartate
-
-
-
-
natural substrates
formimidoylglutamate deiminase
N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3
-
-
-
-
natural substrates
formimidoylaspartate deiminase
N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3
-
-
-
-
natural substrates
imidazoleacetate 4-monooxygenase
4-imidazoleacetate + NADH + H+ + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O
-
-
-
-
natural substrates
putrescine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
BR48925 show the reaction diagram
R02150 show the reaction diagram
2130
-
-
-
-
natural substrates
primary-amine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
BR48925 show the reaction diagram
R02150 show the reaction diagram
2130
-
-
-
-
natural substrates
diamine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
BR48925 show the reaction diagram
R02150 show the reaction diagram
2130
-
-
-
-
natural substrates
monoamine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
BR48925 show the reaction diagram
R02150 show the reaction diagram
2130
-
-
-
-
natural substrates
formimidoyltetrahydrofolate cyclodeaminase
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3
BR3426 show the reaction diagram
R02302 show the reaction diagram
2264
-
-
-
-
natural substrates
tryptophan transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
histidine transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
2-aminoadipate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
kynurenine-oxoglutarate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
histidinol-phosphate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
-
-
-
-
natural substrates
3-(imidazol-5-yl)lactate dehydrogenase
(S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+
-
-
-
: NAD+ (see R04185)
natural substrates
histidine transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
natural substrates
2-aminoadipate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
natural substrates
alanine-glyoxylate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
natural substrates
serine-pyruvate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
natural substrates
phenylalanine(histidine) transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
natural substrates
glutamine-phenylpyruvate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
-
-
-
natural substrates
histidine-tRNA ligase
ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis
BR52 show the reaction diagram
R03655 show the reaction diagram
410
-
-
-
-
natural substrates