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Pathways

ketogluconate metabolism (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

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EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

L-idonate + NAD+ = 5-dehydro-D-gluconate + NADH + H+

: ketogluconate metabolism

: L-idonate degradation,
L-ascorbate degradation IV

: BR26044_WOP

: R05683

: 1.1.1.264-RXN_WOP

, RXN-12107

: 5279

: see R05684 (NADPH)

: The enzyme from Escherichia coli cannot oxidize D-gluconate to form 5-dehydrogluconate, a reaction that is catalyzed by EC 1.1.1.69, gluconate 5-dehydrogenase.

natural substrates

1.1.1.264

L-idonate 5-dehydrogenase

L-idonate + NAD+ = 5-dehydro-D-gluconate + NADH + H+

: ketogluconate metabolism

: L-idonate degradation,
L-ascorbate degradation IV

: BR26044_WOP

: R05683

: 1.1.1.264-RXN_WOP

, RXN-12107

: 5279

: see R05684 (NADPH)

: The enzyme from Escherichia coli cannot oxidize D-gluconate to form 5-dehydrogluconate, a reaction that is catalyzed by EC 1.1.1.69, gluconate 5-dehydrogenase.

natural substrates

1.1.1.366

L-idonate 5-dehydrogenase (NAD+)

L-idonate + NAD+ = 5-dehydro-D-gluconate + NADH + H+

: ketogluconate metabolism

: L-idonate degradation,
L-ascorbate degradation IV

: BR26044_WOP

: R05683

: 1.1.1.264-RXN_WOP

, RXN-12107

: 5279

: see R05684 (NADPH)

: The enzyme from Escherichia coli cannot oxidize D-gluconate to form 5-dehydrogluconate, a reaction that is catalyzed by EC 1.1.1.69, gluconate 5-dehydrogenase.

natural substrates

1.1.1.-

2-dehydro-L-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: ketogluconate metabolism,
L-ascorbate biosynthesis VIII (engineered pathway)

: BR50380

: R08878

: RXN-12105

, RXN0-7020

natural substrates

1.1.1.274

2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)

2-dehydro-L-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: ketogluconate metabolism,
L-ascorbate biosynthesis VIII (engineered pathway)

: BR50380

: R08878

: RXN-12105

, RXN0-7020

natural substrates

1.1.1.346

2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)

2-dehydro-L-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: ketogluconate metabolism,
L-ascorbate biosynthesis VIII (engineered pathway)

: BR50380

: R08878

: RXN-12105

, RXN0-7020

natural substrates

1.1.1.215

gluconate 2-dehydrogenase

D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: Pentose phosphate pathway,
Metabolic pathways,
Microbial metabolism in diverse environments

: ketogluconate metabolism

: BR29257

: R01739

: 1.1.1.215-RXN

: 1847

natural substrates

1.1.1.346

2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)

D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: Pentose phosphate pathway,
Metabolic pathways,
Microbial metabolism in diverse environments

: ketogluconate metabolism

: BR29257

: R01739

: 1.1.1.215-RXN

: 1847

natural substrates

1.1.1.43

phosphogluconate 2-dehydrogenase

D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: Pentose phosphate pathway,
Metabolic pathways,
Microbial metabolism in diverse environments

: ketogluconate metabolism

: BR29257

: R01739

: 1.1.1.215-RXN

: 1847

natural substrates

1.1.1.81

hydroxypyruvate reductase

D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: Pentose phosphate pathway,
Metabolic pathways,
Microbial metabolism in diverse environments

: ketogluconate metabolism

: BR29257

: R01739

: 1.1.1.215-RXN

: 1847

natural substrates

2.7.1.12

gluconokinase

ATP + D-gluconate = ADP + 6-phospho-D-gluconate

: ketogluconate metabolism

: Pentose phosphate pathway,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism

: D-gluconate degradation,
L-idonate degradation,
sorbitol biosynthesis II

: BR47733

: R01737

: GLUCONOKIN-RXN

: 1845

natural substrates

1.1.1.274

2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming)

2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: ketogluconate metabolism,
L-ascorbate biosynthesis VIII (engineered pathway)

: BR40530

: R05823

: 1.1.1.274-RXN

: 5414

natural substrates

1.1.1.346

2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)

2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: ketogluconate metabolism,
L-ascorbate biosynthesis VIII (engineered pathway)

: BR40530

: R05823

: 1.1.1.274-RXN

: 5414

natural substrates

1.1.1.-

L-idonate + NADP+ = 2-keto-L-idonate + NADPH

: ketogluconate metabolism

: ketogluconate metabolism,
L-ascorbate degradation IV

: BS187798

: R08880

: RXN0-7021

natural substrates

1.1.1.215

gluconate 2-dehydrogenase

L-idonate + NADP+ = 2-keto-L-idonate + NADPH

: ketogluconate metabolism

: ketogluconate metabolism,
L-ascorbate degradation IV

: BS187798

: R08880

: RXN0-7021

natural substrates

1.1.1.272

D-2-hydroxyacid dehydrogenase (NADP+)

L-idonate + NADP+ = 2-keto-L-idonate + NADPH

: ketogluconate metabolism

: ketogluconate metabolism,
L-ascorbate degradation IV

: BS187798

: R08880

: RXN0-7021

natural substrates

1.1.1.346

2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming)

L-idonate + NADP+ = 2-keto-L-idonate + NADPH

: ketogluconate metabolism

: ketogluconate metabolism,
L-ascorbate degradation IV

: BS187798

: R08880

: RXN0-7021

natural substrates

1.1.1.264

L-idonate 5-dehydrogenase

L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+

: ketogluconate metabolism

: L-idonate degradation

: BR26044

: R05684

: 1.1.1.264-RXN

, L-IDONATE-2-DEHYDROGENASE-RXN

: see R05683 (NADH)

: The enzyme from Escherichia coli cannot oxidize D-gluconate to form 5-dehydrogluconate, a reaction that is catalyzed by EC 1.1.1.69, gluconate 5-dehydrogenase.

natural substrates

1.1.99.3

gluconate 2-dehydrogenase (acceptor)

D-gluconate + FAD = 2-dehydro-D-gluconate + FADH2

: ketogluconate metabolism

: Pentose phosphate pathway,
Metabolic pathways,
Microbial metabolism in diverse environments

: BS370913

: R01741

: RXN-14204

natural substrates

1.1.1.-

2,5-diketo-D-gluconate + NADPH = 5-keto-D-gluconate + NADP+