Pathways

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BRENDA KEGG MetaCyc

leucine metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
alcohol dehydrogenase
3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+
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: see R05686 (NADPH)
natural substrates
alcohol dehydrogenase (NADP+)
3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+
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: see R05686 (NADPH)
natural substrates
3-methylbutanal reductase
3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+
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: see R05686 (NADPH)
natural substrates
pyruvate decarboxylase
2-oxoisohexanoate = CO2 + isopentanal
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natural substrates
benzoylformate decarboxylase
2-oxoisohexanoate = CO2 + isopentanal
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natural substrates
branched-chain-2-oxoacid decarboxylase
2-oxoisohexanoate = CO2 + isopentanal
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natural substrates
leucine 2,3-aminomutase
(2S)-alpha-leucine = (3R)-beta-leucine
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natural substrates
3-isopropylmalate dehydrogenase
(2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
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: subsequently R01652
natural substrates
3-isopropylmalate dehydratase
(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O
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: Catalyzes the isomerization between (2R,3S)-3-isopropylmalate and 3-hydroxy-4-methyl-3-carboxypentanoate, via the formation of (2S)-2 isopropylmaleate.
natural substrates
(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O
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: Catalyzes the isomerization between (2R,3S)-3-isopropylmalate and 3-hydroxy-4-methyl-3-carboxypentanoate, via the formation of (2S)-2 isopropylmaleate.
natural substrates
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
2-ketoisocaproate + CoA + oxidized ferredoxin = S-(3-methylbutanoyl)-CoA + CO2 + reduced ferredoxin
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natural substrates, generic, protein
indolepyruvate ferredoxin oxidoreductase
2-ketoisocaproate + CoA + oxidized ferredoxin = S-(3-methylbutanoyl)-CoA + CO2 + reduced ferredoxin
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natural substrates, generic, protein
isovaleryl-CoA dehydrogenase
isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2
R04095 show the reaction diagram
3822
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natural substrates
medium-chain acyl-CoA dehydrogenase
isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2
R04095 show the reaction diagram
3822
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natural substrates
methylcrotonoyl-CoA carboxylase
ATP + 3-methylcrotonoyl-CoA + HCO3- + H+ = ADP + phosphate + 3-methylglutaconyl-CoA
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natural substrates
geranoyl-CoA carboxylase
ATP + 3-methylcrotonoyl-CoA + HCO3- + H+ = ADP + phosphate + 3-methylglutaconyl-CoA
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natural substrates
methylglutaconyl-CoA hydratase
(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O
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natural substrates
leucine-tRNA ligase
ATP + L-leucine + tRNALeu = AMP + diphosphate + L-leucyl-tRNALeu
BR55 show the reaction diagram
R03657 show the reaction diagram
412
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natural substrates