Pathways

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BRENDA KEGG MetaCyc

lipid metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
acetyl-CoA hydrolase
n-butyryl-CoA + H2O = CoA + n-butanoate
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palmitoyl-CoA hydrolase
n-butyryl-CoA + H2O = CoA + n-butanoate
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acyl-CoA hydrolase
n-butyryl-CoA + H2O = CoA + n-butanoate
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4-hydroxybenzoyl-CoA thioesterase
n-butyryl-CoA + H2O = CoA + n-butanoate
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4-acetamidobutyryl-CoA deacetylase
n-butyryl-CoA + H2O = CoA + n-butanoate
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acetyl-CoA C-acyltransferase
n-butyryl-CoA + H2O = CoA + n-butanoate
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acetyl-CoA C-acyltransferase
hexanoyl-CoA + H2O = CoA + hexanoate
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natural substrates
acetyl-CoA hydrolase
hexanoyl-CoA + H2O = CoA + hexanoate
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natural substrates
ADP-dependent medium-chain-acyl-CoA hydrolase
hexanoyl-CoA + H2O = CoA + hexanoate
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natural substrates
palmitoyl-CoA hydrolase
hexanoyl-CoA + H2O = CoA + hexanoate
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natural substrates
acyl-CoA hydrolase
hexanoyl-CoA + H2O = CoA + hexanoate
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natural substrates
4-hydroxybenzoyl-CoA thioesterase
hexanoyl-CoA + H2O = CoA + hexanoate
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natural substrates
long-chain-fatty-acid-CoA ligase
ATP + palmitoleate + CoA = AMP + diphosphate + palmitoleoyl-CoA
BS295 show the reaction diagram
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natural substrates
short-chain acyl-CoA dehydrogenase
butyryl-CoA + acceptor = but-2-enoyl-CoA + reduced acceptor
1415
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isovaleryl-CoA dehydrogenase
butyryl-CoA + acceptor = but-2-enoyl-CoA + reduced acceptor
1415
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medium-chain acyl-CoA dehydrogenase
butyryl-CoA + acceptor = but-2-enoyl-CoA + reduced acceptor
1415
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2-methylacyl-CoA dehydrogenase
butyryl-CoA + acceptor = but-2-enoyl-CoA + reduced acceptor
1415
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acyl-CoA oxidase
palmitoyl-CoA + O2 = 2-trans-hexadecenoyl-CoA + H2O2
6538
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medium-chain acyl-CoA dehydrogenase
hexadecanoyl-CoA + acceptor = 2-hexadecenoyl-CoA + reduced acceptor
R01282 show the reaction diagram
1498
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: incomplete reaction
natural substrates
long-chain acyl-CoA dehydrogenase
hexadecanoyl-CoA + acceptor = 2-hexadecenoyl-CoA + reduced acceptor
R01282 show the reaction diagram
1498
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: incomplete reaction
natural substrates
hexadecanoyl-CoA + acceptor = 2-hexadecenoyl-CoA + reduced acceptor
R01282 show the reaction diagram
1498
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: incomplete reaction
natural substrates
DELTA3-DELTA2-enoyl-CoA isomerase
3-trans-Hexadecenoyl-CoA = 2-trans-Hexadecenoyl-CoA
BS1118 show the reaction diagram
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acyl-CoA oxidase
butyryl-CoA + O2 = trans-2-butenoyl-CoA + H2O2
9597
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short-chain acyl-CoA dehydrogenase
butyryl-CoA + O2 = trans-2-butenoyl-CoA + H2O2
9597
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short-chain acyl-CoA dehydrogenase
2-butenoyl-CoA + reduced electron transfer flavoprotein = butanoyl-CoA + electron transfer protein
generic compounds
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natural substrates
oxepin-CoA hydrolase
(R)-3-hydroxybutyryl-CoA = trans-2-butenoyl-CoA + H2O
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natural substrates
acetoacetyl-CoA reductase
(R)-3-hydroxybutyryl-CoA = trans-2-butenoyl-CoA + H2O
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natural substrates
acetate-CoA ligase
ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA
BS143 show the reaction diagram
R01176 show the reaction diagram
1413
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natural substrates
propionate-CoA ligase
ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA
BS143 show the reaction diagram
R01176 show the reaction diagram
1413
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natural substrates
medium-chain acyl-CoA ligase
ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA
BS143 show the reaction diagram
R01176 show the reaction diagram
1413
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natural substrates
long-chain-fatty-acid-CoA ligase
ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA
BS143 show the reaction diagram
R01176 show the reaction diagram
1413
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natural substrates
phenylacetate-CoA ligase
ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA
BS143 show the reaction diagram
R01176 show the reaction diagram
1413
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natural substrates
3-hydroxypropionyl-CoA synthase
ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA
BS143 show the reaction diagram
R01176 show the reaction diagram
1413
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natural substrates
3-(methylthio)propionyl-CoA ligase
ATP + butyrate + CoA = AMP + diphosphate + butyryl-CoA
BS143 show the reaction diagram
R01176 show the reaction diagram
1413
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natural substrates
acetoacetyl-CoA reductase
(R)-3-hydroxybutyryl-CoA + NADPH + H+ = 3-oxobutyryl-CoA + NADP+
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natural substrates
galactolipase
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
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natural substrates
phospholipase A1
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
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natural substrates
phospholipase A2
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
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natural substrates
lysophospholipase
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
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natural substrates
glycerol-3-phosphate 1-dehydrogenase (NADP+)
sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + NADPH + H+
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natural substrates
alcohol dehydrogenase (NADP+)
sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + NADPH + H+
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natural substrates
aldehyde reductase
sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + NADPH + H+
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natural substrates
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + NADPH + H+
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natural substrates
triacylglycerol lipase
triacylglycerol + H2O = diacylglycerol + a carboxylate
BR10653 show the reaction diagram
R01369 show the reaction diagram
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: general reaction also hydrolyzing at sn-1 position
natural substrates, generic
lipoprotein lipase
triacylglycerol + H2O = diacylglycerol + a carboxylate
BR10653 show the reaction diagram
R01369 show the reaction diagram
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: general reaction also hydrolyzing at sn-1 position
natural substrates, generic
hormone-sensitive lipase
triacylglycerol + H2O = diacylglycerol + a carboxylate
BR10653 show the reaction diagram
R01369 show the reaction diagram
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: general reaction also hydrolyzing at sn-1 position
natural substrates, generic
sterol esterase
triacylglycerol + H2O = diacylglycerol + a carboxylate
BR10653 show the reaction diagram
R01369 show the reaction diagram
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: general reaction also hydrolyzing at sn-1 position
natural substrates, generic
2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor = 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
R10331 show the reaction diagram
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natural substrates, generic
archaetidylserine synthase
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
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natural substrates
phosphoglycerol geranylgeranyltransferase
geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
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natural substrates
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase
CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
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natural substrates
geranylgeranylglycerol-phosphate geranylgeranyltransferase
geranylgeranyl diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
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natural substrates
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
BR48095 show the reaction diagram
R01625 show the reaction diagram
335
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natural substrates
holo-[acyl-carrier-protein] synthase
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
BR48095 show the reaction diagram
R01625 show the reaction diagram
335
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natural substrates
[acyl-carrier-protein] phosphodiesterase
holo-[acyl-carrier protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier protein]
BR15954 show the reaction diagram
R01623 show the reaction diagram
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natural substrates, generic, protein
trans-2-decenoyl-[acyl-carrier protein] isomerase
a trans-dec-2-enoyl-[acyl-carrier protein] = a cis-dec-3-enoyl-[acyl-carrier protein]
BR48706 show the reaction diagram
R07639 show the reaction diagram
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natural substrates
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
(3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2-decenoyl-[acyl-carrier protein] + H2O
BS2050 show the reaction diagram
R04535 show the reaction diagram
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natural substrates, generic, protein
fatty-acid synthase
(3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2-decenoyl-[acyl-carrier protein] + H2O
BS2050 show the reaction diagram
R04535 show the reaction diagram
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natural substrates, generic, protein
fatty-acyl-CoA synthase
(3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2-decenoyl-[acyl-carrier protein] + H2O
BS2050 show the reaction diagram
R04535 show the reaction diagram
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natural substrates, generic, protein
(3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2-decenoyl-[acyl-carrier protein] + H2O
BS2050 show the reaction diagram
R04535 show the reaction diagram
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natural substrates, generic, protein
2,4-dienoyl-CoA reductase (NADPH)
2,4-trans-hexadienoyl-CoA + NADPH = trans-3-hexenoyl-CoA + NADP+
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3-oxoacyl-[acyl-carrier-protein] reductase
acetoacetyl-[acyl-carrier protein] + NADPH = D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+
R04533 show the reaction diagram
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natural substrates
acyl-CoA oxidase
hexanoyl-CoA + O2 = (2E)-hex-2-enoyl-CoA + H2O2
9568
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DELTA3-DELTA2-enoyl-CoA isomerase
3-trans-Hexenoyl-CoA = 2-trans-Hexenoyl-CoA
BS1110 show the reaction diagram
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natural substrates
5.3.3.M5
3-trans-Hexenoyl-CoA = 2-trans-Hexenoyl-CoA
BS1110 show the reaction diagram
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natural substrates
long-chain-3-hydroxyacyl-CoA dehydrogenase
(S)-3-hydroxyhexanoyl-CoA + NAD+ = 3-oxohexanoyl-CoA + NADH + H+
R04748 show the reaction diagram
4404
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natural substrates
3-hydroxyacyl-CoA dehydrogenase
(S)-3-hydroxyhexanoyl-CoA + NAD+ = 3-oxohexanoyl-CoA + NADH + H+
R04748 show the reaction diagram
4404
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natural substrates
cyclopropane-fatty-acyl-phospholipid synthase
S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid
BR43921 show the reaction diagram
R03411 show the reaction diagram
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natural substrates
fatty-acid synthase
malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein]
BR44039 show the reaction diagram
R01626 show the reaction diagram
1767
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natural substrates
fatty-acyl-CoA synthase
malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein]
BR44039 show the reaction diagram
R01626 show the reaction diagram
1767
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natural substrates
malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein]
BR44039 show the reaction diagram
R01626 show the reaction diagram
1767
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natural substrates
[acyl-carrier-protein] S-malonyltransferase
malonyl-CoA + an [acyl-carrier protein] = CoA + a malonyl-[acyl-carrier protein]
BR44039 show the reaction diagram
R01626 show the reaction diagram
1767
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natural substrates
beta-ketoacyl-[acyl-carrier-protein] synthase III
acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2
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natural substrates
malonyl-S-ACP decarboxylase
a malonyl-[acyl-carrier protein] = an acetyl-[acyl-carrier protein] + CO2
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natural substrates
4.1.1.M15
a malonyl-[acyl-carrier protein] = an acetyl-[acyl-carrier protein] + CO2
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natural substrates
beta-ketoacyl-[acyl-carrier-protein] synthase I
a malonyl-[acyl-carrier protein] = an acetyl-[acyl-carrier protein] + CO2
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natural substrates
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein]
BR44038 show the reaction diagram
R01624 show the reaction diagram
1766
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natural substrates
beta-ketoacyl-[acyl-carrier-protein] synthase III
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein]
BR44038 show the reaction diagram
R01624 show the reaction diagram
1766
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natural substrates
[acyl-carrier-protein] S-acetyltransferase
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein]
BR44038 show the reaction diagram
R01624 show the reaction diagram
1766
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natural substrates
[acyl-carrier-protein] S-malonyltransferase
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein]
BR44038 show the reaction diagram
R01624 show the reaction diagram
1766
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natural substrates
fatty-acid synthase
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein]
BR44038 show the reaction diagram
R01624 show the reaction diagram
1766
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natural substrates
fatty-acyl-CoA synthase
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein]
BR44038 show the reaction diagram
R01624 show the reaction diagram
1766
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natural substrates
holo-[acyl-carrier-protein] synthase
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein]
BR44038 show the reaction diagram
R01624 show the reaction diagram
1766
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natural substrates
acylglycerol lipase
CnHmCO-C3O3H7 + H2O = CnHmCO2H + glycerol
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: see R01352 (2-acyl type reaction)
natural substrates
triacylglycerol lipase
CnHmCO-C3O3H7 + H2O = CnHmCO2H + glycerol
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: see R01352 (2-acyl type reaction)
natural substrates
fatty-acyl-ethyl-ester synthase
CnHmCO-C3O3H7 + H2O = CnHmCO2H + glycerol
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: see R01352 (2-acyl type reaction)
natural substrates
hormone-sensitive lipase
CnHmCO-C3O3H7 + H2O = CnHmCO2H + glycerol
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: see R01352 (2-acyl type reaction)
natural substrates
2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]
2,3-bis-(O-phytanyl)-sn-glycerol 1-phosphate + 8 NADP+ = 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate + 8 NADPH + 8 H+
BR50484 show the reaction diagram
R10326 show the reaction diagram
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natural substrates
archaetidylserine synthase
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + L-serine = CMP + 2,3-bis-(O-phytanyl)-sn-glycero-1-phospho-L-serine
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natural substrates
archaetidylinositol phosphate synthase
CDP-2,3-bis-(O-phytanyl)-sn-glycerol + 1L-myo-inositol 1-phosphate = CMP + 1-archaetidyl-1D-myo-inositol 3-phosphate
BR50489 show the reaction diagram
R10464 show the reaction diagram
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natural substrates
archaetidylinositol phosphate phosphatase
1-archaetidyl-1D-myo-inositol 3-phosphate + H2O = 1-archaetidyl-1D-myo-inositol + phosphate
BR50490 show the reaction diagram
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natural substrates
monoglucosylarchaeol synthase
UDP-alpha-D-glucose + archaeol = UDP + 1,2-bis-phytanyl-sn-glycero-3-O-beta-D-glucoside
BR50424 show the reaction diagram
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natural substrates
diglucosylarchaeol synthase
UDP-alpha-D-glucose + 1,2-diphytanyl-sn-glycero-3-O-beta-D-glucoside = UDP + 1,2-diphytanyl-sn-glycero-3-O-(6-O-beta-D-glucosyl)-beta-D-glucoside
BR50425 show the reaction diagram
incomplete
H4C2
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natural substrates
carboxylic acid-CoA ligase (GDP-forming)
GTP + butyrate + CoA = GDP + phosphate + butyryl-CoA
BS150 show the reaction diagram
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acetate-CoA ligase (ADP-forming)
ADP + phosphate + butyryl-CoA = ATP + butyrate + CoA
BS165 show the reaction diagram
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succinate-CoA ligase (ADP-forming)
ADP + phosphate + butyryl-CoA = ATP + butyrate + CoA
BS165 show the reaction diagram
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malate-CoA ligase
ADP + phosphate + butyryl-CoA = ATP + butyrate + CoA
BS165 show the reaction diagram
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carboxylic acid-CoA ligase (NDP-forming)
ADP + phosphate + butyryl-CoA = ATP + butyrate + CoA
BS165 show the reaction diagram
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meromycolic acid enoyl-[acyl-carrier-protein] reductase
trans-2-hexadecenoyl-CoA + NADH = hexadecanoyl-CoA + NAD+
1492
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trans-2-enoyl-CoA reductase (NADPH)
trans-2-hexadecenoyl-CoA + NADH = hexadecanoyl-CoA + NAD+
1492
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trans-2-enoyl-CoA reductase (NAD+)
trans-2-hexadecenoyl-CoA + NADH = hexadecanoyl-CoA + NAD+
1492
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enoyl-[acyl-carrier-protein] reductase (NADH)
trans-2-hexadecenoyl-CoA + NADH = hexadecanoyl-CoA + NAD+
1492
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trans-2-enoyl-CoA reductase (NADPH)
2-trans-hexadecenoyl-CoA + NADPH = hexadecanoyl CoA + NADP+
R01278 show the reaction diagram
1494
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natural substrates
acyl-CoA dehydrogenase (NADP+)
2-trans-hexadecenoyl-CoA + NADPH = hexadecanoyl CoA + NADP+
R01278 show the reaction diagram
1494
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natural substrates
2,4-dienoyl-CoA reductase (NADPH)
trans-trans-2,4-hexadecadienoyl-CoA + NADPH = trans-2-hexadecenoyl-CoA + NADP+
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natural substrates
acetate-CoA ligase
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA
BR71 show the reaction diagram
R00389 show the reaction diagram
8094
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-
: general reaction
natural substrates
4-coumarate-CoA ligase
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA
BR71 show the reaction diagram
R00389 show the reaction diagram
8094
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-
: general reaction
natural substrates
medium-chain acyl-CoA ligase
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA
BR71 show the reaction diagram
R00389 show the reaction diagram
8094
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: general reaction
natural substrates
long-chain-fatty-acid-CoA ligase
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA
BR71 show the reaction diagram
R00389 show the reaction diagram
8094
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: general reaction
natural substrates
3-(methylthio)propionyl-CoA ligase
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA
BR71 show the reaction diagram
R00389 show the reaction diagram
8094
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: general reaction
natural substrates
enoyl-CoA hydratase
trans-2-hexenoyl-CoA + H2O = (3S)-3-hydroxyhexanoyl-CoA
BS2101 show the reaction diagram
R04749 show the reaction diagram
4405
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natural substrates
long-chain-enoyl-CoA hydratase
trans-2-hexenoyl-CoA + H2O = (3S)-3-hydroxyhexanoyl-CoA
BS2101 show the reaction diagram
R04749 show the reaction diagram
4405
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natural substrates