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BRENDA KEGG MetaCyc

methionine metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
methionine-tRNA ligase
ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet
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natural substrates
adenosylhomocysteinase
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
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: multi-step reaction
natural substrates, multi-step reaction
cystathionine gamma-synthase
O-phospho-L-homoserine + L-cysteine = L-cystathionine + phosphate
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natural substrates
methionine gamma-lyase
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
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: multi-step reaction (see R08635+R08637)
natural substrates, multi-step reaction
DNA (cytosine-5-)-methyltransferase
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
R00380 show the reaction diagram
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: see R04858
natural substrates, nucleotide
homocysteine S-methyltransferase
S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine
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natural substrates
methionine synthase
S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine
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natural substrates
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine
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natural substrates
selenocysteine Se-methyltransferase
S-adenosyl-L-methionine + L-homocysteine = methionine + S-adenosyl-L-homocysteine
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natural substrates
methionine synthase
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine
BR40552 show the reaction diagram
R00946 show the reaction diagram
1260
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natural substrates
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine
BR40552 show the reaction diagram
R00946 show the reaction diagram
1260
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natural substrates
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
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natural substrates
homoserine O-succinyltransferase
succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine
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natural substrates
asparagine-oxo-acid transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
glutamine-pyruvate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
tryptophan-phenylpyruvate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
branched-chain-amino-acid transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
serine-pyruvate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
aromatic-amino-acid transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
phenylalanine(histidine) transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
aromatic-amino-acid-glyoxylate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
glutamine-phenylpyruvate transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
methionine transaminase
alpha-ketomethiobutyrate + L-phenylalanine = L-methionine + phenylpyruvate
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natural substrates
L-amino-acid oxidase
L-methionine + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
R00648 show the reaction diagram
1033
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natural substrates
phenylalanine 2-monooxygenase
L-methionine + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
R00648 show the reaction diagram
1033
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natural substrates
acireductone dioxygenase [iron(II)-requiring]
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-(methylsulfanyl)-2-oxobutanoate + formate
BR48660 show the reaction diagram
R07364 show the reaction diagram
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natural substrates
acireductone synthase
2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
BR48755 show the reaction diagram
R07394 show the reaction diagram
R83-RXN show the reaction diagram
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: the second step of two-step reaction (see R07395, R07393+R07394)
natural substrates
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
BR48755 show the reaction diagram
R07394 show the reaction diagram
R83-RXN show the reaction diagram
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: the second step of two-step reaction (see R07395, R07393+R07394)
natural substrates
acireductone synthase
5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
BR48754 show the reaction diagram
R07393 show the reaction diagram
R82-RXN show the reaction diagram
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: the first step of two-step reaction (see R07395, R07393+R07394) in some species.
natural substrates
ribulose-bisphosphate carboxylase
5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
BR48754 show the reaction diagram
R07393 show the reaction diagram
R82-RXN show the reaction diagram
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: the first step of two-step reaction (see R07395, R07393+R07394) in some species.
natural substrates
phosphopyruvate hydratase
5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
BR48754 show the reaction diagram
R07393 show the reaction diagram
R82-RXN show the reaction diagram
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: the first step of two-step reaction (see R07395, R07393+R07394) in some species.
natural substrates
2,3-diketo-5-methylthiopentyl-1-phosphate enolase
5-(methylsulfanyl)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylsulfanyl)-3-oxopent-1-enyl phosphate
BR48754 show the reaction diagram
R07393 show the reaction diagram
R82-RXN show the reaction diagram
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: the first step of two-step reaction (see R07395, R07393+R07394) in some species.
natural substrates
methylthioribulose 1-phosphate dehydratase
5-methylsulfanyl-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O
BR48756 show the reaction diagram
R07392 show the reaction diagram
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natural substrates
S-methyl-5-thioribose-1-phosphate isomerase
S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
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natural substrates
S-methyl-5-thioribose kinase
ATP + S-methyl-5-thio-D-ribose = ADP + S-methyl-5-thio-alpha-D-ribose 1-phosphate
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natural substrates
methylthioadenosine nucleosidase
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine
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natural substrates
adenosylhomocysteine nucleosidase
S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine
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natural substrates
peptide-methionine (S)-S-oxide reductase
L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O
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natural substrates, generic
peptide-methionine (R)-S-oxide reductase
L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O
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natural substrates, generic
L-methionine (R)-S-oxide reductase
L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O
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natural substrates, generic
thioredoxin-independent methionine sulfoxide reductases B
L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O
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natural substrates, generic
nicotianamine synthase
3 S-adenosyl-L-methionine = 3 S-methyl-5'-thioadenosine + nicotianamine
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: multi-step reaction
natural substrates, multi-step reaction
S-adenosyl-L-methionine hydroxide adenosyltransferase
S-adenosyl-L-methionine + H2O = adenosine + L-methionine + H+
BR49470 show the reaction diagram
R12098 show the reaction diagram
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natural substrates
S-adenosyl-L-methionine hydrolase (adenosine-forming)
S-adenosyl-L-methionine + H2O = adenosine + L-methionine + H+
BR49470 show the reaction diagram
R12098 show the reaction diagram
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natural substrates