Print
succinyl-CoA:mesaconate CoA transferase
Pathways
methylaspartate cycle (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate
; "show the reaction diagram")
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natural substrates
methylmalonyl-CoA mutase
(R)-methylmalonyl-CoA = succinyl-CoA
: Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,pyruvate fermentation to propanoate I,
methylaspartate cycle,
3-hydroxypropanoate cycle,
3-hydroxypropanoate/4-hydroxybutanate cycle,
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
anaerobic energy metabolism (invertebrates, mitochondrial),
propanoyl CoA degradation I,
conversion of succinate to propanoate
; "show the reaction diagram")
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natural substrates
ethylmalonyl-CoA mutase
(R)-methylmalonyl-CoA = succinyl-CoA
: Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,pyruvate fermentation to propanoate I,
methylaspartate cycle,
3-hydroxypropanoate cycle,
3-hydroxypropanoate/4-hydroxybutanate cycle,
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
anaerobic energy metabolism (invertebrates, mitochondrial),
propanoyl CoA degradation I,
conversion of succinate to propanoate
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natural substrates
2-hydroxyisobutanoyl-CoA mutase
(R)-methylmalonyl-CoA = succinyl-CoA
: Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: (S)-lactate fermentation to propanoate, acetate and hydrogen,pyruvate fermentation to propanoate I,
methylaspartate cycle,
3-hydroxypropanoate cycle,
3-hydroxypropanoate/4-hydroxybutanate cycle,
crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered),
anaerobic energy metabolism (invertebrates, mitochondrial),
propanoyl CoA degradation I,
conversion of succinate to propanoate
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natural substrates
(3S)-malyl-CoA thioesterase
(S)-malyl-CoA + H2O = (S)-malate + CoA
; "show the reaction diagram")
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natural substrates
succinate dehydrogenase
succinate + a quinone = fumarate + a quinol
; "show the reaction diagram")
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: electron transport complex IInatural substrates, multi-step reaction
fumarate reductase (quinol)
succinate + a quinone = fumarate + a quinol
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: electron transport complex IInatural substrates, multi-step reaction
citrate (Si)-synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
: Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
ethene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
; "show the reaction diagram")
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: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16): Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].natural substrates
homocitrate synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
: Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
ethene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
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: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16): Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].natural substrates
citrate synthase (unknown stereospecificity)
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
: Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
ethene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
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: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16): Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].natural substrates
citrate (Re)-synthase
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
: Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
ethene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
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: (pro-S)-carboxymethyl-forming (ec 2.3.3.1) (pro-R)-carboxymethyl-forming (ec 2.3.3.3) unknown stereospecificity (ec 2.3.3.16): Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582]. The reaction occurs in peroxisome in fungi [1897942] and plants [15923350] and in bacterial cytosol[4211224]; Citrate synthase is located solely in the mitochondrial matrix. Citrate enters the mitochondrial matrix to react with the enzyme. Experiments done in rat liver indicate that this reaction is physiologically irreversible [7060582].natural substrates
acetate-CoA ligase (ADP-forming)
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
: Citrate cycle (TCA cycle),Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle V (2-oxoglutarate synthase),TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
pyruvate fermentation to acetate VI,
pyruvate fermentation to acetate V
; "show the reaction diagram")
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natural substrates
succinate-CoA ligase (GDP-forming)
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
: Citrate cycle (TCA cycle),Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle V (2-oxoglutarate synthase),TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
pyruvate fermentation to acetate VI,
pyruvate fermentation to acetate V
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natural substrates
succinate-CoA ligase (ADP-forming)
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
: Citrate cycle (TCA cycle),Propanoate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle V (2-oxoglutarate synthase),TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
pyruvate fermentation to acetate VI,
pyruvate fermentation to acetate V
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natural substrates
methylmalonyl-CoA epimerase
(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA
; "show the reaction diagram")
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natural substrates
acetyl-CoA carboxylase
ATP + propanoyl-CoA + HCO3- + H+ = ADP + phosphate + (S)-methylmalonyl-CoA
; "show the reaction diagram")
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: possibly two-step reaction (similar to R00742 or R04385+R04386)natural substrates
propionyl-CoA carboxylase
ATP + propanoyl-CoA + HCO3- + H+ = ADP + phosphate + (S)-methylmalonyl-CoA
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: possibly two-step reaction (similar to R00742 or R04385+R04386)natural substrates
malyl-CoA lyase
(S)-malyl-CoA = acetyl-CoA + glyoxylate
; "show the reaction diagram")
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natural substrates
D-lactate dehydrogenase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
; "show the reaction diagram")
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natural substrates
malate dehydrogenase [NAD(P)+]
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
L-2-hydroxycarboxylate dehydrogenase (NAD+)
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
malate dehydrogenase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
malate dehydrogenase (oxaloacetate-decarboxylating)
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
hydroxypyruvate reductase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
malate dehydrogenase (NADP+)
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
3-isopropylmalate dehydrogenase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
phosphoglycerate dehydrogenase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
diiodophenylpyruvate reductase
(S)-malate + NAD+ = oxaloacetate + NADH + H+
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Methane metabolism,
Carbon fixation in photosynthetic organisms,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
C4 photosynthetic carbon assimilation cycle, NAD-ME type,
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
formaldehyde assimilation I (serine pathway),
methylaspartate cycle,
gluconeogenesis I,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, cytosol),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
gluconeogenesis III,
glyoxylate cycle,
mixed acid fermentation,
malate/L-aspartate shuttle pathway
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natural substrates
methylaspartate ammonia-lyase
L-threo-3-methylaspartate = mesaconate + NH3
; "show the reaction diagram")
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natural substrates
fumarate hydratase
(S)-malate = fumarate + H2O
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
methylaspartate cycle,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
; "show the reaction diagram")
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-
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natural substrates
(S)-2-methylmalate dehydratase
(S)-malate = fumarate + H2O
: Citrate cycle (TCA cycle),Pyruvate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
(S)-lactate fermentation to propanoate, acetate and hydrogen,
pyruvate fermentation to propanoate I,
TCA cycle III (animals),
methylaspartate cycle,
superpathway of glyoxylate cycle and fatty acid degradation,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
anaerobic energy metabolism (invertebrates, mitochondrial),
reductive TCA cycle II,
incomplete reductive TCA cycle,
reductive TCA cycle I,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
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-
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-
natural substrates
methylaspartate mutase
L-threo-3-methylaspartate = L-glutamate
; "show the reaction diagram")
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-
-
-
natural substrates
2-methylfumaryl-CoA hydratase
(2R,3S)-2-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O
; "show the reaction diagram")
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-
-
-
natural substrates
3-methylfumaryl-CoA hydratase
(2R,3S)-2-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O
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-
-
-
natural substrates
aconitate hydratase
citrate = cis-aconitate + H2O
: Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
reductive TCA cycle II,
reductive TCA cycle I,
ethene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
; "show the reaction diagram")
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-
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natural substrates
2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
citrate = cis-aconitate + H2O
: Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
reductive TCA cycle II,
reductive TCA cycle I,
ethene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
-
-
-
-
natural substrates
citrate = cis-aconitate + H2O
: Citrate cycle (TCA cycle),Glyoxylate and dicarboxylate metabolism,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
2-Oxocarboxylic acid metabolism
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
TCA cycle III (animals),
methylaspartate cycle,
TCA cycle II (plants and fungi),
TCA cycle I (prokaryotic),
reductive TCA cycle II,
reductive TCA cycle I,
ethene biosynthesis V (engineered),
glyoxylate cycle,
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
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-
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natural substrates
isocitrate-homoisocitrate dehydrogenase
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
: Glutathione metabolism,Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
methylaspartate cycle,
TCA cycle I (prokaryotic),
reductive TCA cycle I,
cytosolic NADPH production (yeast),
ethene biosynthesis V (engineered),
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
; "show the reaction diagram")
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-
-
: two-step reaction (see R01899+R00268)natural substrates
isocitrate dehydrogenase (NAD+)
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
: Glutathione metabolism,Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
methylaspartate cycle,
TCA cycle I (prokaryotic),
reductive TCA cycle I,
cytosolic NADPH production (yeast),
ethene biosynthesis V (engineered),
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
-
-
-
: two-step reaction (see R01899+R00268)natural substrates
isocitrate dehydrogenase (NADP+)
isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+
: Glutathione metabolism,Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: TCA cycle IV (2-oxoglutarate decarboxylase),TCA cycle V (2-oxoglutarate synthase),
TCA cycle VII (acetate-producers),
partial TCA cycle (obligate autotrophs),
methylaspartate cycle,
TCA cycle I (prokaryotic),
reductive TCA cycle I,
cytosolic NADPH production (yeast),
ethene biosynthesis V (engineered),
L-glutamine biosynthesis III,
mixed acid fermentation,
TCA cycle VI (Helicobacter)
-
-
-
: two-step reaction (see R01899+R00268)natural substrates
malyl-CoA lyase
(2R,3S)-2-methylmalyl-CoA = propanoyl-CoA + glyoxylate
; "show the reaction diagram")
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-
-
-
natural substrates