Print
isoprene synthase
Pathways
mevalonate metabolism (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
dimethylallyl diphosphate = isoprene + diphosphate
; "show the reaction diagram")
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natural substrates
adenylate dimethylallyltransferase (ADP/ATP-dependent)
dimethylallyl diphosphate + ADP = diphosphate + N6-(dimethylallyl)adenosine 5'-diphosphate
; "show the reaction diagram")
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natural substrates
adenylate dimethylallyltransferase
dimethylallyl diphosphate + ADP = diphosphate + N6-(dimethylallyl)adenosine 5'-diphosphate
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natural substrates
bisphosphomevalonate decarboxylase
(R)-3,5-bisphosphomevalonate = isopentenyl phosphate + CO2 + phosphate
; "show the reaction diagram")
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: This hypothetical reaction is catalyzed by an as yet unidentified mevalonate-3,5-bisphosphate decarboxylase |CITS: [24914732][24755225]|.natural substrates
hydroxymethylglutaryl-CoA reductase (NADPH)
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
; "show the reaction diagram")
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natural substrates
hydroxymethylglutaryl-CoA reductase
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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natural substrates
hydroxymethylglutaryl-CoA reductase [NAD(P)H]
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
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natural substrates
diphosphomevalonate decarboxylase
ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2
; "show the reaction diagram")
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: possibly intermediate ((R)-5-diphospho-3-phosphomevalonate)natural substrates
phosphomevalonate kinase
ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate
; "show the reaction diagram")
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natural substrates
isopentenyl phosphate kinase
ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate
; "show the reaction diagram")
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natural substrates
isopentenyl-diphosphate DELTA-isomerase
Isopentenyl diphosphate = dimethylallyl diphosphate
: trans, trans-farnesyl diphosphate biosynthesis,mevalonate pathway IV (archaea),
mono-trans, poly-cis decaprenyl phosphate biosynthesis,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
all-trans-farnesol biosynthesis,
methylerythritol phosphate pathway I,
methylerythritol phosphate pathway II,
isoprene biosynthesis II (engineered),
bisabolene biosynthesis (engineered),
mevalonate pathway II (haloarchaea)
; "show the reaction diagram")
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natural substrates
hydroxymethylglutaryl-CoA synthase
acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
; "show the reaction diagram")
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: possibly two-step reaction (acetoacetyl-CoA-lyase, thioester-hydrolysing)natural substrates
mevalonate kinase
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
; "show the reaction diagram")
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natural substrates
acetyl-CoA C-myristoyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Synthesis and degradation of ketone bodies,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: L-glutamate degradation V (via hydroxyglutarate),acetyl-CoA fermentation to butanoate II,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
pyruvate fermentation to hexanol (engineered),
2-deoxy-D-ribose degradation II,
3-hydroxypropanoate/4-hydroxybutanate cycle,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
; "show the reaction diagram")
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natural substrates
acetyl-CoA C-acyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Synthesis and degradation of ketone bodies,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: L-glutamate degradation V (via hydroxyglutarate),acetyl-CoA fermentation to butanoate II,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
pyruvate fermentation to hexanol (engineered),
2-deoxy-D-ribose degradation II,
3-hydroxypropanoate/4-hydroxybutanate cycle,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
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natural substrates
[acyl-carrier-protein] S-acetyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Synthesis and degradation of ketone bodies,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: L-glutamate degradation V (via hydroxyglutarate),acetyl-CoA fermentation to butanoate II,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
pyruvate fermentation to hexanol (engineered),
2-deoxy-D-ribose degradation II,
3-hydroxypropanoate/4-hydroxybutanate cycle,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
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natural substrates
acetyl-CoA C-acetyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Synthesis and degradation of ketone bodies,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: L-glutamate degradation V (via hydroxyglutarate),acetyl-CoA fermentation to butanoate II,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
pyruvate fermentation to hexanol (engineered),
2-deoxy-D-ribose degradation II,
3-hydroxypropanoate/4-hydroxybutanate cycle,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
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natural substrates
hydroxymethylglutaryl-CoA reductase (NADPH)
2 acetyl-CoA = CoA + acetoacetyl-CoA
: Fatty acid degradation,Synthesis and degradation of ketone bodies,
Valine, leucine and isoleucine degradation,
Lysine degradation,
Benzoate degradation,
Tryptophan metabolism,
Pyruvate metabolism,
Glyoxylate and dicarboxylate metabolism,
Propanoate metabolism,
Butanoate metabolism,
Carbon fixation pathways in prokaryotes,
Terpenoid backbone biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Carbon metabolism,
Fatty acid metabolism
: L-glutamate degradation V (via hydroxyglutarate),acetyl-CoA fermentation to butanoate II,
L-lysine fermentation to acetate and butanoate,
pyruvate fermentation to butanoate,
pyruvate fermentation to butanol I,
mevalonate pathway IV (archaea),
oleate beta-oxidation,
pyruvate fermentation to hexanol (engineered),
2-deoxy-D-ribose degradation II,
3-hydroxypropanoate/4-hydroxybutanate cycle,
crotonate fermentation (to acetate and cyclohexane carboxylate),
methyl tert-butyl ether degradation,
2-methylpropene degradation,
mevalonate pathway III (Thermoplasma),
mevalonate pathway I (eukaryotes and bacteria),
ethylmalonyl-CoA pathway,
glutaryl-CoA degradation,
isoprene biosynthesis II (engineered),
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered),
pyruvate fermentation to butanol II (engineered),
isopropanol biosynthesis (engineered),
polyhydroxybutanoate biosynthesis,
pyruvate fermentation to acetone,
ketolysis,
ketogenesis,
mevalonate pathway II (haloarchaea),
acetoacetate degradation (to acetyl CoA)
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natural substrates
hydroxymethylglutaryl-CoA reductase (NADPH)
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
; "show the reaction diagram")
: 6923-
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natural substrates
hydroxymethylglutaryl-CoA reductase
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
: 6923-
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natural substrates
hydroxymethylglutaryl-CoA reductase [NAD(P)H]
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
: 6923-
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natural substrates
mevalonate 3-kinase
ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate
; "show the reaction diagram")
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natural substrates
mevalonate-3-phosphate 5-kinase
ATP + (R)-3-phosphomevalonate = ADP + (R)-3,5-bisphosphomevalonate
; "show the reaction diagram")
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natural substrates