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cytochrome-c oxidase
Pathways
oxidative phosphorylation (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
reduced cytochrome c + O2 + H+ = oxidized cytochrome c + H2O
generic compounds
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generic, protein
; "show the reaction diagram")
non-chaperonin molecular chaperone ATPase
ATP + H2O = ADP + phosphate
: 75-
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natural substrates
chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing)
ATP + H2O = ADP + phosphate
: 75-
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natural substrates
7.1.2.2
H+-transporting two-sector ATPase
ATP + H2O = ADP + phosphate
: 75-
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natural substrates
7.2.2.1
Na+-transporting two-sector ATPase
ATP + H2O = ADP + phosphate
: 75-
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natural substrates
ubiquinol oxidase (non-electrogenic)
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]
: aerobic respiration III (alternative oxidase pathway),pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
; "show the reaction diagram")
; "show the reaction diagram")
; "show the reaction diagram")
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: two-step reaction (see R11885+R11886)natural substrates
menaquinol oxidase (H+-transporting)
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]
: aerobic respiration III (alternative oxidase pathway),pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
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: two-step reaction (see R11885+R11886)natural substrates
7.1.1.3
ubiquinol oxidase (H+-transporting)
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]
: aerobic respiration III (alternative oxidase pathway),pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
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: two-step reaction (see R11885+R11886)natural substrates
7.1.1.7
ubiquinol oxidase (electrogenic, proton-motive force generating)
2 ubiquinol + O2 + n H+[side 1] = 2 ubiquinone + 2 H2O + n H+[side 2]
: aerobic respiration III (alternative oxidase pathway),pyruvate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer II,
succinate to cytochrome bd oxidase electron transfer,
NADH to cytochrome bd oxidase electron transfer I,
glycerol-3-phosphate to cytochrome bo oxidase electron transfer,
D-lactate to cytochrome bo oxidase electron transfer,
pyruvate to cytochrome bo oxidase electron transfer,
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bo oxidase electron transfer I,
proline to cytochrome bo oxidase electron transfer,
succinate to cytochrome bo oxidase electron transfer
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: two-step reaction (see R11885+R11886)natural substrates
NADPH dehydrogenase (quinone)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
: aerobic respiration I (cytochrome c),aerobic respiration III (alternative oxidase pathway),
Fe(II) oxidation,
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD/NADH phosphorylation and dephosphorylation,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
; "show the reaction diagram")
; "show the reaction diagram")
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: electron transport complex Inatural substrates, multi-step reaction
NADH dehydrogenase (quinone)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
: aerobic respiration I (cytochrome c),aerobic respiration III (alternative oxidase pathway),
Fe(II) oxidation,
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD/NADH phosphorylation and dephosphorylation,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
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: electron transport complex Inatural substrates, multi-step reaction
NAD(P)H dehydrogenase (quinone)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
: aerobic respiration I (cytochrome c),aerobic respiration III (alternative oxidase pathway),
Fe(II) oxidation,
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD/NADH phosphorylation and dephosphorylation,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
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: electron transport complex Inatural substrates, multi-step reaction
NADH:ubiquinone reductase (non-electrogenic)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
: aerobic respiration I (cytochrome c),aerobic respiration III (alternative oxidase pathway),
Fe(II) oxidation,
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD/NADH phosphorylation and dephosphorylation,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
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: electron transport complex Inatural substrates, multi-step reaction
NADH dehydrogenase
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
: aerobic respiration I (cytochrome c),aerobic respiration III (alternative oxidase pathway),
Fe(II) oxidation,
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD/NADH phosphorylation and dephosphorylation,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
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: electron transport complex Inatural substrates, multi-step reaction
NADH dehydrogenase (quinone)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
: aerobic respiration I (cytochrome c),aerobic respiration III (alternative oxidase pathway),
Fe(II) oxidation,
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD/NADH phosphorylation and dephosphorylation,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
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: electron transport complex Inatural substrates, multi-step reaction
dihydrolipoyl dehydrogenase
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
: aerobic respiration I (cytochrome c),aerobic respiration III (alternative oxidase pathway),
Fe(II) oxidation,
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD/NADH phosphorylation and dephosphorylation,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
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: electron transport complex Inatural substrates, multi-step reaction
7.1.1.2
NADH:ubiquinone reductase (H+-translocating)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
: aerobic respiration I (cytochrome c),aerobic respiration III (alternative oxidase pathway),
Fe(II) oxidation,
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD/NADH phosphorylation and dephosphorylation,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
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: electron transport complex Inatural substrates, multi-step reaction
7.2.1.1
NADH:ubiquinone reductase (Na+-transporting)
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2]
: aerobic respiration I (cytochrome c),aerobic respiration III (alternative oxidase pathway),
Fe(II) oxidation,
NADH to cytochrome bo oxidase electron transfer I,
NADH to cytochrome bd oxidase electron transfer I,
NAD/NADH phosphorylation and dephosphorylation,
nitrate reduction VIIIb (dissimilatory),
NADH to cytochrome bo oxidase electron transfer II,
NADH to cytochrome bd oxidase electron transfer II,
aerobic respiration II (cytochrome c) (yeast),
NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)
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: electron transport complex Inatural substrates, multi-step reaction
ferredoxin-NADP+ reductase
reduced ferredoxin + NAD+ + H+ = oxidized ferredoxin + NADH
; "show the reaction diagram")
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natural substrates
ferredoxin-NAD+ reductase
reduced ferredoxin + NAD+ + H+ = oxidized ferredoxin + NADH
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natural substrates
adrenodoxin-NADP+ reductase
reduced ferredoxin + NAD+ + H+ = oxidized ferredoxin + NADH
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natural substrates
NADH dehydrogenase
reduced ferredoxin + NAD+ + H+ = oxidized ferredoxin + NADH
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natural substrates