Pathways

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BRENDA KEGG MetaCyc

pyrimidine metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
dCTP diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
dUTP diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
8-oxo-dGTP diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
(d)CTP diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
nucleotide diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
dihydroorotate dehydrogenase (NAD+)
dihydroorotate + NAD+ = orotate + NADH + H+
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natural substrates
purine nucleosidase
cytidine + H2O = D-ribose + cytosine
R02137 show the reaction diagram
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natural substrates
uridine nucleosidase
cytidine + H2O = D-ribose + cytosine
R02137 show the reaction diagram
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natural substrates
ribosylpyrimidine nucleosidase
cytidine + H2O = D-ribose + cytosine
R02137 show the reaction diagram
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natural substrates
purine nucleosidase
uridine + H2O = D-ribose + uracil
BR32612 show the reaction diagram
R01080 show the reaction diagram
472
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natural substrates
uridine nucleosidase
uridine + H2O = D-ribose + uracil
BR32612 show the reaction diagram
R01080 show the reaction diagram
472
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natural substrates
ribosylpyrimidine nucleosidase
uridine + H2O = D-ribose + uracil
BR32612 show the reaction diagram
R01080 show the reaction diagram
472
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natural substrates
dCTP diphosphatase
dCDP + H2O = dCMP + phosphate
R01667 show the reaction diagram
482
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natural substrates
nucleoside-triphosphate phosphatase
dCDP + H2O = dCMP + phosphate
R01667 show the reaction diagram
482
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natural substrates
8-oxo-dGTP diphosphatase
dCDP + H2O = dCMP + phosphate
R01667 show the reaction diagram
482
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natural substrates
nucleoside diphosphate phosphatase
dCDP + H2O = dCMP + phosphate
R01667 show the reaction diagram
482
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natural substrates
nucleotide diphosphatase
dCDP + H2O = dCMP + phosphate
R01667 show the reaction diagram
482
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natural substrates
dihydropyrimidine dehydrogenase (NAD+)
thymine + NADPH = dihydrothymine + NADP+
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natural substrates
dihydropyrimidine dehydrogenase (NADP+)
thymine + NADPH = dihydrothymine + NADP+
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natural substrates
dihydropyrimidinase
beta-ureidoisobutyrate = dihydrothymine + H2O
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natural substrates
(R)-3-amino-2-methylpropionate-pyruvate transaminase
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
BR47992 show the reaction diagram
R02050 show the reaction diagram
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natural substrates
beta-ureidopropionase
2-methyl-N-carbamoyl-beta-alanine + H2O = 2-methyl-beta-alanine + CO2 + NH3
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natural substrates
adenylate kinase
ATP + CDP = ADP + CTP
R00570 show the reaction diagram
208
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natural substrates
nucleoside-diphosphate kinase
ATP + CDP = ADP + CTP
R00570 show the reaction diagram
208
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natural substrates
CTP synthase (glutamine hydrolysing)
ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate
BR48389 show the reaction diagram
R00573 show the reaction diagram
459
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natural substrates
nucleoside-diphosphate kinase
ATP + UDP = ADP + UTP
R00156 show the reaction diagram
199
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natural substrates
UMP/CMP kinase
ATP + UMP = ADP + UDP
BR48071 show the reaction diagram
R00158 show the reaction diagram
201
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natural substrates
UMP kinase
ATP + UMP = ADP + UDP
BR48071 show the reaction diagram
R00158 show the reaction diagram
201
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natural substrates
nucleoside-phosphate kinase
ATP + UMP = ADP + UDP
BR48071 show the reaction diagram
R00158 show the reaction diagram
201
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natural substrates
guanylate kinase
ATP + UMP = ADP + UDP
BR48071 show the reaction diagram
R00158 show the reaction diagram
201
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natural substrates
orotidine-5'-phosphate decarboxylase
orotidine 5'-phosphate = UMP + CO2
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natural substrates
orotate phosphoribosyltransferase
orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
dihydroorotase
dihydroorotate + H2O = N-carbamoyl-L-aspartate
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aspartate carbamoyltransferase
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate
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natural substrates
ribonucleoside-triphosphate reductase (thioredoxin)
UDP + reduced thioredoxin = dUDP + oxidized thioredoxin + H2O
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natural substrates, generic
thymidylate synthase
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
BR43900 show the reaction diagram
R02101 show the reaction diagram
88
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natural substrates
deoxynucleoside kinase
2'-deoxyuridine + ATP = 2'-deoxyuridine 5'-phosphate + ADP
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natural substrates
thymidine kinase
2'-deoxyuridine + ATP = 2'-deoxyuridine 5'-phosphate + ADP
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natural substrates
deoxycytidine kinase
2'-deoxyuridine + ATP = 2'-deoxyuridine 5'-phosphate + ADP
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natural substrates
2'-deoxyadenosine kinase
2'-deoxyuridine + ATP = 2'-deoxyuridine 5'-phosphate + ADP
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natural substrates
dCMP deaminase
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
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natural substrates
cytidine deaminase
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
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natural substrates
purine-nucleoside phosphorylase
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
pyrimidine-nucleoside phosphorylase
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
uridine phosphorylase
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
thymidine phosphorylase
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
pyrimidine-nucleoside phosphorylase
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
uridine phosphorylase
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
thymidine phosphorylase
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
pyrimidine-nucleoside phosphorylase
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
BR47549 show the reaction diagram
R01876 show the reaction diagram
204
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natural substrates
uridine phosphorylase
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
BR47549 show the reaction diagram
R01876 show the reaction diagram
204
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natural substrates
thymidine phosphorylase
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
BR47549 show the reaction diagram
R01876 show the reaction diagram
204
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natural substrates
deoxynucleoside kinase
ATP + thymidine = ADP + dTMP
BR47761 show the reaction diagram
R01567 show the reaction diagram
90
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natural substrates
thymidine kinase
ATP + thymidine = ADP + dTMP
BR47761 show the reaction diagram
R01567 show the reaction diagram
90
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natural substrates
deoxycytidine kinase
ATP + thymidine = ADP + dTMP
BR47761 show the reaction diagram
R01567 show the reaction diagram
90
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natural substrates
2'-deoxyadenosine kinase
ATP + thymidine = ADP + dTMP
BR47761 show the reaction diagram
R01567 show the reaction diagram
90
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natural substrates
nucleoside phosphotransferase
ATP + thymidine = ADP + dTMP
BR47761 show the reaction diagram
R01567 show the reaction diagram
90
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natural substrates
dTMP kinase
ATP + thymidine = ADP + dTMP
BR47761 show the reaction diagram
R01567 show the reaction diagram
90
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natural substrates
uridine kinase
GTP + uridine = UMP + GDP
R00968 show the reaction diagram
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natural substrates
cytidine kinase
GTP + cytidine = CMP + GDP
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natural substrates
uridine kinase
GTP + cytidine = CMP + GDP
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natural substrates
broad specificity nucleoside kinase
GTP + cytidine = CMP + GDP
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natural substrates
uridine kinase
ATP + CMP = ADP + CDP
R00512 show the reaction diagram
83
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natural substrates
UMP/CMP kinase
ATP + CMP = ADP + CDP
R00512 show the reaction diagram
83
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natural substrates
(d)CMP kinase
ATP + CMP = ADP + CDP
R00512 show the reaction diagram
83
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natural substrates
adenylate kinase
ATP + CMP = ADP + CDP
R00512 show the reaction diagram
83
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natural substrates
guanylate kinase
ATP + CMP = ADP + CDP
R00512 show the reaction diagram
83
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natural substrates
dihydroorotate dehydrogenase (quinone)
dihydroorotate + O2 = orotate + H2O2
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dihydroorotate dehydrogenase (fumarate)
dihydroorotate + O2 = orotate + H2O2
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thymidylate synthase (FAD)
5,10-methylenetetrahydrofolate + dUMP + FADH2 = dTMP + tetrahydrofolate + FAD
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natural substrates
dCTP deaminase (dUMP-forming)
dCTP + 2 H2O = dUMP + diphosphate + NH3
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natural substrates
(d)CTP diphosphatase
CTP + H2O = CMP + diphosphate
BR50549 show the reaction diagram
R00515 show the reaction diagram
454
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natural substrates
ATP diphosphatase
CTP + H2O = CMP + diphosphate
BR50549 show the reaction diagram
R00515 show the reaction diagram
454
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natural substrates
nucleotide diphosphatase
CTP + H2O = CMP + diphosphate
BR50549 show the reaction diagram
R00515 show the reaction diagram
454
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natural substrates
alkaline phosphatase
CMP + H2O = cytidine + phosphate
BR50761 show the reaction diagram
R00511 show the reaction diagram
211
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natural substrates
acid phosphatase
CMP + H2O = cytidine + phosphate
BR50761 show the reaction diagram
R00511 show the reaction diagram
211
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natural substrates
inositol-phosphate phosphatase
CMP + H2O = cytidine + phosphate
BR50761 show the reaction diagram
R00511 show the reaction diagram
211
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natural substrates
nucleotidase
CMP + H2O = cytidine + phosphate
BR50761 show the reaction diagram
R00511 show the reaction diagram
211
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natural substrates
5'-nucleotidase
CMP + H2O = cytidine + phosphate
BR50761 show the reaction diagram
R00511 show the reaction diagram
211
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natural substrates
7-methylguanosine nucleotidase
CMP + H2O = cytidine + phosphate
BR50761 show the reaction diagram
R00511 show the reaction diagram
211
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natural substrates