Print
methylenetetrahydrofolate reductase [NAD(P)H]
Pathways
reductive acetyl coenzyme A pathway (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin + 2 H+
; "show the reaction diagram")
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natural substrates, generic, protein
methylenetetrahydrofolate reductase (ferredoxin)
5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin + 2 H+
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natural substrates, generic, protein
methylenetetrahydrofolate dehydrogenase (NAD+)
5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+
: One carbon pool by folate,Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: formaldehyde oxidation VII (THF pathway),formate assimilation into 5,10-methylenetetrahydrofolate,
N10-formyl-tetrahydrofolate biosynthesis,
folate transformations I,
folate transformations II,
purine nucleobases degradation II (anaerobic),
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria)
; "show the reaction diagram")
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natural substrates
methylenetetrahydrofolate dehydrogenase (NADP+)
5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+
: One carbon pool by folate,Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: formaldehyde oxidation VII (THF pathway),formate assimilation into 5,10-methylenetetrahydrofolate,
N10-formyl-tetrahydrofolate biosynthesis,
folate transformations I,
folate transformations II,
purine nucleobases degradation II (anaerobic),
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria)
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natural substrates
formate dehydrogenase (acceptor)
formate + acceptor = CO2 + reduced acceptor
; "show the reaction diagram")
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natural substrates, generic
formate dehydrogenase (NADP+)
formate + NAD+ = CO2 + NADH + H+
; "show the reaction diagram")
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natural substrates
formate dehydrogenase
formate + NAD+ = CO2 + NADH + H+
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natural substrates
methenyltetrahydrofolate cyclohydrolase
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate
: One carbon pool by folate,Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: formaldehyde oxidation VII (THF pathway),formate assimilation into 5,10-methylenetetrahydrofolate,
N10-formyl-tetrahydrofolate biosynthesis,
folate transformations I,
folate transformations II,
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate,
purine nucleobases degradation I (anaerobic),
purine nucleobases degradation II (anaerobic),
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria),
L-histidine degradation III
; "show the reaction diagram")
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natural substrates
formate-tetrahydrofolate ligase
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate
; "show the reaction diagram")
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natural substrates
anaerobic carbon-monoxide dehydrogenase
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+
; "show the reaction diagram")
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natural substrates, generic, protein
formate dehydrogenase (NADP+)
formate + NADP+ = CO2 + NADPH + H+
; "show the reaction diagram")
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natural substrates
formate dehydrogenase
formate + NADP+ = CO2 + NADPH + H+
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natural substrates