Pathways

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BRENDA KEGG MetaCyc

sesquiterpene lactone biosynthesis (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
eupatolide synthase
8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = 6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
generic compounds
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: the first step of two-step reaction (see R12270, R12267+R12268)
natural substrates, generic, protein
SPONTANEOUS
8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate = 8-epi-inunolide + H2O
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: spontaneous the second step of two-step reaction (see R12275, R12273+R12274)
natural substrates
8-epi-inunolide synthase
8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate = 8-epi-inunolide + H2O
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: spontaneous the second step of two-step reaction (see R12275, R12273+R12274)
natural substrates
eupatolide synthase
6alpha,8beta-Dihydroxygermacra-1(10),4,11(13)-trien-12-oate <=> Eupatolide + H2O
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-
-
: spontaneous the second step of two-step reaction (see R12270, R12267+R12268)
natural substrates
SPONTANEOUS
6alpha,8beta-Dihydroxygermacra-1(10),4,11(13)-trien-12-oate <=> Eupatolide + H2O
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-
-
: spontaneous the second step of two-step reaction (see R12270, R12267+R12268)
natural substrates
8-epi-inunolide synthase
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
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-
-
: the first step of two-step reaction (see R12275, R12273+R12274)
natural substrates, generic, protein
germacrene A acid 8beta-hydroxylase
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
natural substrates, generic, protein
costunolide synthase
6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate = (+)-costunolide + H2O
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-
-
: spontaneous the second step of two-step reaction (see R09575, R12131+R12132)
natural substrates
SPONTANEOUS
6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate = (+)-costunolide + H2O
-
-
-
: spontaneous the second step of two-step reaction (see R09575, R12131+R12132)
natural substrates
costunolide synthase
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
: the first step of two-step reaction (see R09575, R12131+R12132)
natural substrates, generic, protein
amorpha-4,11-diene 12-monooxygenase
artemisinic aldehyde + O2 + [reduced NADPH-hemoprotein reductase] = artemisinate + [oxidized NADPH-hemoprotein reductase] + H2O
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: the last step of three-step reaction (see R10026, R10023+R10024+R10025)
natural substrates, generic, protein
amorpha-4,11-diene 12-monooxygenase
artemisinic alcohol + O2 + [reduced NADPH-hemoprotein reductase] = artemisinic aldehyde + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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-
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: the second step of three-step reaction (see R10026, R10023+R10024+R10025)
natural substrates, generic, protein
amorpha-4,11-diene 12-monooxygenase
amorpha-4,11-diene + O2 + [reduced NADPH-hemoprotein reductase] = artemisinic alcohol + [oxidized NADPH-hemoprotein reductase] + H2O
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: the first step of three-step reaction (see R10026, R10023+R10024+R10025)
natural substrates, generic, protein
amorpha-4,11-diene synthase
(2E,6E)-farnesyl diphosphate = amorpha-4,11-diene + diphosphate
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natural substrates
artemisinate + oxygen + H+ = (-)-arteannuin B + H2O
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natural substrates
0.0.0.0
spontaneous reaction
artemisinate + oxygen + H+ = (-)-arteannuin B + H2O
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natural substrates
2-alkenal reductase [NAD(P)+]
(11R)-dihydroartemisinic aldehyde + NADP+ = artemisinic aldehyde + NADPH + H+
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natural substrates
artemisinic aldehyde DELTA11(13)-reductase
(11R)-dihydroartemisinic aldehyde + NADP+ = artemisinic aldehyde + NADPH + H+
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-
natural substrates
germacrene A hydroxylase
(+)-germacrene A + O2 + [reduced NADPH-hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-ol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
: the first step of three-step reaction (see R12128, R09549+R12129+R12130)
natural substrates, generic, protein
germacrene A hydroxylase
germacra-1(10),4,11(13)-trien-12-ol + O2 + [reduced NADPH-hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-al + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
-
-
: the second step of three-step reaction (see R12128, R09549+R12129+R12130)
natural substrates, generic, protein
germacrene A hydroxylase
germacra-1(10),4,11(13)-trien-12-al + O2 + [reduced NADPH-hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
: the last step of three-step reaction (see R12128, R09549+R12129+R12130)
natural substrates, generic, protein