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BRENDA KEGG MetaCyc

taxol biosynthesis (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
taxane 13alpha-hydroxylase
taxa-4(20),11-dien-5alpha-ol + [reduced NADPH-hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha,13alpha-diol + [oxidized NADPH-hemoprotein reductase] + H2O
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natural substrates, protein
taxoid 14beta-hydroxylase
10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O
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natural substrates
taxoid C-13 O-phenylpropanoyltransferase
baccatin III + 3-amino-3-phenylpropanoyl-CoA = 3'-N-debenzoyl-2'-deoxytaxol + coenzyme A
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natural substrates
10-deacetylbaccatin III 10-O-acetyltransferase
acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III
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natural substrates
taxadiene synthase
geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate
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natural substrates
taxadiene 5alpha-hydroxylase
taxa-4,11-diene + [reduced NADPH-hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha-ol + [oxidized NADPH-hemoprotein reductase] + H2O
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natural substrates, generic, protein
taxadien-5alpha-ol O-acetyltransferase
acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate
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natural substrates
taxane 10beta-hydroxylase
taxa-4(20),11-dien-5alpha-yl acetate + [reduced NADPH-hemoprotein reductase] + O2 = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + [oxidized NADPH-hemoprotein reductase] + H2O
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natural substrates, generic, protein
2alpha-hydroxytaxane 2-O-benzoyltransferase
benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III
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natural substrates