Pathways

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BRENDA KEGG MetaCyc

tetrahydrofolate metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
5-formyltetrahydrofolate cyclo-ligase
ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methylenetetrahydrofolate
: tetrahydrofolate metabolism
: BS638show the reaction diagram
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GTP cyclohydrolase I
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis,
tetrahydrofolate metabolism
: threo-tetrahydrobiopterin biosynthesis,
erythro-tetrahydrobiopterin biosynthesis I,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium),
drosopterin and aurodrosopterin biosynthesis,
tetrahydromonapterin biosynthesis,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I,
preQ0 biosynthesis
: BR22737show the reaction diagram
: R00424show the reaction diagram
: GTP-CYCLOHYDRO-I-RXNshow the reaction diagram
: 9177
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: four-step reaction (see R00428+R05046+R05048+R04639)
natural substrates
dihydrofolate synthase
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
: tetrahydrofolate metabolism
: Folate biosynthesis,
Metabolic pathways
: tetrahydrofolate biosynthesis
: BR104show the reaction diagram
: R02237show the reaction diagram
: DIHYDROFOLATESYNTH-RXNshow the reaction diagram
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natural substrates
tetrahydrofolate synthase
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
: tetrahydrofolate metabolism
: Folate biosynthesis,
Metabolic pathways
: tetrahydrofolate biosynthesis
: BR104show the reaction diagram
: R02237show the reaction diagram
: DIHYDROFOLATESYNTH-RXNshow the reaction diagram
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natural substrates
aminodeoxychorismate lyase
4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate
: tetrahydrofolate metabolism
: Folate biosynthesis
: 4-aminobenzoate biosynthesis
: BR47975show the reaction diagram
: R05553show the reaction diagram
: ADCLY-RXNshow the reaction diagram
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: ADC Lyase, PabC see R01716
natural substrates
dihydrofolate reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
: tetrahydrofolate metabolism
: One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways
: folate transformations III (E. coli),
tetrahydrofolate biosynthesis,
folate transformations II (plants)
: BR36900show the reaction diagram
: R00939show the reaction diagram
: DIHYDROFOLATEREDUCT-RXNshow the reaction diagram, RXN-19329show the reaction diagram
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: NADH (see R00936)
natural substrates
pteridine reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
: tetrahydrofolate metabolism
: One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways
: folate transformations III (E. coli),
tetrahydrofolate biosynthesis,
folate transformations II (plants)
: BR36900show the reaction diagram
: R00939show the reaction diagram
: DIHYDROFOLATEREDUCT-RXNshow the reaction diagram, RXN-19329show the reaction diagram
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: NADH (see R00936)
natural substrates
6,7-dihydropteridine reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
: tetrahydrofolate metabolism
: One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways
: folate transformations III (E. coli),
tetrahydrofolate biosynthesis,
folate transformations II (plants)
: BR36900show the reaction diagram
: R00939show the reaction diagram
: DIHYDROFOLATEREDUCT-RXNshow the reaction diagram, RXN-19329show the reaction diagram
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: NADH (see R00936)
natural substrates
dihydromonapterin reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
: tetrahydrofolate metabolism
: One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways
: folate transformations III (E. coli),
tetrahydrofolate biosynthesis,
folate transformations II (plants)
: BR36900show the reaction diagram
: R00939show the reaction diagram
: DIHYDROFOLATEREDUCT-RXNshow the reaction diagram, RXN-19329show the reaction diagram
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: NADH (see R00936)
natural substrates
phosphoribosylglycinamide formyltransferase
10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
: tetrahydrofolate metabolism,
purine metabolism
: Purine metabolism,
One carbon pool by folate,
Metabolic pathways,
Biosynthesis of secondary metabolites
: tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate,
5-aminoimidazole ribonucleotide biosynthesis I
: BR43941show the reaction diagram
: R04325show the reaction diagram
: GART-RXNshow the reaction diagram
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natural substrates
aminodeoxychorismate synthase
chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
: tetrahydrofolate metabolism
: Folate biosynthesis
: chloramphenicol biosynthesis,
4-aminobenzoate biosynthesis
: BR47979show the reaction diagram
: R01716show the reaction diagram
: PABASYN-RXNshow the reaction diagram
: 1828
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: two-step reaction (see R00256 + R05552)
natural substrates
methylenetetrahydrofolate reductase [NAD(P)H]
5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+
: tetrahydrofolate metabolism
: One carbon pool by folate,
Metabolic pathways,
Microbial metabolism in diverse environments
: BR36896show the reaction diagram
: R01224show the reaction diagram
: 1453
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natural substrates
formyltetrahydrofolate deformylase
10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate
: tetrahydrofolate metabolism
: Glyoxylate and dicarboxylate metabolism,
One carbon pool by folate
: purine nucleobases degradation I (anaerobic),
folate transformations I,
formaldehyde oxidation VII (THF pathway),
purine nucleobases degradation II (anaerobic)
: BR22680show the reaction diagram
: R00944show the reaction diagram
: FORMYLTHFDEFORMYL-RXNshow the reaction diagram
: 1259
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: This reaction produces formate from formyl-THF, providing the major source of formate for the purT-dependent synthesis of 5'-phosphoribosyl-N-formylglycinamide (FGAR) during aerobic growth. It may also play a role in regulating the 1-carbon pool.
natural substrates
6-carboxytetrahydropterin synthase
7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
: tetrahydrofolate metabolism
: Folate biosynthesis,
Metabolic pathways
: preQ0 biosynthesis
: BR50066show the reaction diagram
: R09959show the reaction diagram
: RXN0-5507show the reaction diagram
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: multi-step reaction possibly intermediate (see [CPD:C03684], R04286)
natural substrates, multi-step reaction
7-carboxy-7-deazaguanine synthase
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3
: tetrahydrofolate metabolism
: Folate biosynthesis,
Metabolic pathways
: preQ0 biosynthesis
: BR50129show the reaction diagram
: R10002show the reaction diagram
: RXN0-6575show the reaction diagram
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: radical SAM
natural substrates
7-cyano-7-deazaguanine synthase
7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O
: tetrahydrofolate metabolism
: Folate biosynthesis,
Metabolic pathways
: preQ0 biosynthesis
: BR50022show the reaction diagram
: R09978show the reaction diagram
: RXN-12093show the reaction diagram
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natural substrates
dihydroneopterin triphosphate 2'-epimerase
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
: tetrahydrofolate metabolism
: Folate biosynthesis
: tetrahydromonapterin biosynthesis
: BR51427show the reaction diagram
: R11082show the reaction diagram
: H2NTPEPIM-RXNshow the reaction diagram
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natural substrates
7,8-dihydroneopterin epimerase
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
: tetrahydrofolate metabolism
: Folate biosynthesis
: tetrahydromonapterin biosynthesis
: BR51427show the reaction diagram
: R11082show the reaction diagram
: H2NTPEPIM-RXNshow the reaction diagram
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natural substrates
6,7-dihydropteridine reductase
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+
: tetrahydrofolate metabolism
: Folate biosynthesis
: tetrahydromonapterin biosynthesis
: BR51347show the reaction diagram
: R11019show the reaction diagram
: RXN0-6367show the reaction diagram
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natural substrates
dihydromonapterin reductase
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+
: tetrahydrofolate metabolism
: Folate biosynthesis
: tetrahydromonapterin biosynthesis
: BR51347show the reaction diagram
: R11019show the reaction diagram
: RXN0-6367show the reaction diagram
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natural substrates