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5-formyltetrahydrofolate cyclo-ligase
Pathways
tetrahydrofolate metabolism (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methylenetetrahydrofolate
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dihydropteroate synthase
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate
; "show the reaction diagram")
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natural substrates
GTP cyclohydrolase I
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium),drosopterin and aurodrosopterin biosynthesis,
tetrahydromonapterin biosynthesis,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I,
threo-tetrahydrobiopterin biosynthesis,
preQ0 biosynthesis,
erythro-tetrahydrobiopterin biosynthesis II,
erythro-tetrahydrobiopterin biosynthesis I
; "show the reaction diagram")
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: four-step reaction (see R00428+R05046+R05048+R04639)natural substrates
dihydrofolate synthase
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
; "show the reaction diagram")
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natural substrates
tetrahydrofolate synthase
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
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natural substrates
aminodeoxychorismate lyase
4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate
; "show the reaction diagram")
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: ADC Lyase, PabC see R01716natural substrates
dihydrofolate reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
; "show the reaction diagram")
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: NADH (see R00936)natural substrates
pteridine reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
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: NADH (see R00936)natural substrates
6,7-dihydropteridine reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
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: NADH (see R00936)natural substrates
methylenetetrahydrofolate dehydrogenase (NADP+)
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
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: NADH (see R00936)natural substrates
dihydromonapterin reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
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: NADH (see R00936)natural substrates
phosphoribosylglycinamide formyltransferase
10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
; "show the reaction diagram")
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natural substrates
aminodeoxychorismate synthase
chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
; "show the reaction diagram")
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: two-step reaction (see R00256 + R05552)natural substrates
methylenetetrahydrofolate reductase [NAD(P)H]
5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+
; "show the reaction diagram")
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natural substrates
formyltetrahydrofolate deformylase
10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate
; "show the reaction diagram")
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natural substrates
6-carboxytetrahydropterin synthase
7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
; "show the reaction diagram")
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: multi-step reaction possibly intermediate (see [CPD:C03684], R04286)natural substrates, multi-step reaction
7-carboxy-7-deazaguanine synthase
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3
; "show the reaction diagram")
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: radical SAMnatural substrates
7-cyano-7-deazaguanine synthase
7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O
; "show the reaction diagram")
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natural substrates
dihydroneopterin triphosphate 2'-epimerase
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
; "show the reaction diagram")
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natural substrates
7,8-dihydroneopterin epimerase
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
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natural substrates
6,7-dihydropteridine reductase
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+
; "show the reaction diagram")
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natural substrates
dihydromonapterin reductase
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+
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natural substrates