5-formyltetrahydrofolate cyclo-ligase
Pathways
tetrahydrofolate metabolism (BRENDA)






EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methylenetetrahydrofolate
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GTP cyclohydrolase I
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate

erythro-tetrahydrobiopterin biosynthesis I,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium),
drosopterin and aurodrosopterin biosynthesis,
tetrahydromonapterin biosynthesis,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I,
preQ0 biosynthesis
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natural substrates
dihydrofolate synthase
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
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natural substrates
tetrahydrofolate synthase
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
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natural substrates
aminodeoxychorismate lyase
4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate
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natural substrates
dihydrofolate reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
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natural substrates
pteridine reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
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natural substrates
6,7-dihydropteridine reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
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natural substrates
dihydromonapterin reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
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natural substrates
phosphoribosylglycinamide formyltransferase
10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
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natural substrates
aminodeoxychorismate synthase
chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
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natural substrates
methylenetetrahydrofolate reductase [NAD(P)H]
5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+
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natural substrates
formyltetrahydrofolate deformylase
10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate
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natural substrates
6-carboxytetrahydropterin synthase
7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
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natural substrates, multi-step reaction
7-carboxy-7-deazaguanine synthase
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3
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natural substrates
7-cyano-7-deazaguanine synthase
7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O
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natural substrates
dihydroneopterin triphosphate 2'-epimerase
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
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natural substrates
7,8-dihydroneopterin epimerase
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
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natural substrates
6,7-dihydropteridine reductase
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+
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natural substrates
dihydromonapterin reductase
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+
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natural substrates