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Pathways

tetrahydrofolate metabolism (BRENDA)

:= BRENDA,

:= KEGG,

:= MetaCyc,

:= SABIO-RK

:= amino acid sequences

:= show the reaction diagram

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EC Number

Reaction

Pathways

Reaction IDs

Stoichiometry Check

Missing Substrate

Missing Product

Commentary

Remark

1.5.1.34

6,7-dihydropteridine reductase

5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+

: tetrahydrofolate metabolism

: Folate biosynthesis

: tetrahydromonapterin biosynthesis

: BR51347

: R11019

: RXN0-6367

natural substrates

1.5.1.50

dihydromonapterin reductase

5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+

: tetrahydrofolate metabolism

: Folate biosynthesis

: tetrahydromonapterin biosynthesis

: BR51347

: R11019

: RXN0-6367

natural substrates

5.1.99.7

dihydroneopterin triphosphate 2'-epimerase

7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate

: tetrahydrofolate metabolism

: Folate biosynthesis

: tetrahydromonapterin biosynthesis

: BR51427

: R11082

: H2NTPEPIM-RXN

natural substrates

5.1.99.8

7,8-dihydroneopterin epimerase

7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate

: tetrahydrofolate metabolism

: Folate biosynthesis

: tetrahydromonapterin biosynthesis

: BR51427

: R11082

: H2NTPEPIM-RXN

natural substrates

6.3.4.20

7-cyano-7-deazaguanine synthase

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O

: tetrahydrofolate metabolism

: Folate biosynthesis,
Metabolic pathways

: preQ0 biosynthesis

: BR50022

: R09978

: RXN-12093

natural substrates

4.3.99.3

7-carboxy-7-deazaguanine synthase

6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3

: tetrahydrofolate metabolism

: Folate biosynthesis,
Metabolic pathways

: preQ0 biosynthesis

: BR50129

: R10002

: RXN0-6575

: radical SAM

natural substrates

4.1.2.50

6-carboxytetrahydropterin synthase

7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

: tetrahydrofolate metabolism

: Folate biosynthesis,
Metabolic pathways

: preQ0 biosynthesis

: BR50066

: R09959

: RXN0-5507

: multi-step reaction possibly intermediate (see [CPD:C03684], R04286)

natural substrates, multi-step reaction

3.5.1.10

formyltetrahydrofolate deformylase

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate

: tetrahydrofolate metabolism

: Glyoxylate and dicarboxylate metabolism,
One carbon pool by folate

: BR22680

: R00944

: 1259

natural substrates

1.5.1.20

methylenetetrahydrofolate reductase [NAD(P)H]

5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+

: tetrahydrofolate metabolism

: One carbon pool by folate,
Metabolic pathways,
Microbial metabolism in diverse environments

: BR36896

: R01224

: 1453

natural substrates

2.6.1.85

aminodeoxychorismate synthase

chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate

: tetrahydrofolate metabolism

: Folate biosynthesis

: chloramphenicol biosynthesis,
4-aminobenzoate biosynthesis

: BR47979

: R01716

: PABASYN-RXN

: 1828

: two-step reaction (see R00256 + R05552)

natural substrates

2.1.2.2

phosphoribosylglycinamide formyltransferase

10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide

: purine metabolism,
tetrahydrofolate metabolism

: Purine metabolism,
One carbon pool by folate,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics

: BR43941

: R04325

natural substrates

1.5.1.3

dihydrofolate reductase

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

: tetrahydrofolate metabolism

: One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways

: BR36900

: R00939

: RXN-19329

: 100

: NADH (see R00936)

natural substrates

1.5.1.33

pteridine reductase

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

: tetrahydrofolate metabolism

: One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways

: BR36900

: R00939

: RXN-19329

: 100

: NADH (see R00936)

natural substrates

1.5.1.34

6,7-dihydropteridine reductase

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

: tetrahydrofolate metabolism

: One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways

: BR36900

: R00939

: RXN-19329

: 100

: NADH (see R00936)

natural substrates

1.5.1.5

methylenetetrahydrofolate dehydrogenase (NADP+)

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

: tetrahydrofolate metabolism

: One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways

: BR36900

: R00939

: RXN-19329

: 100

: NADH (see R00936)

natural substrates

1.5.1.50

dihydromonapterin reductase

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+

: tetrahydrofolate metabolism

: One carbon pool by folate,
Folate biosynthesis,
Metabolic pathways

: BR36900

: R00939

: RXN-19329

: 100

: NADH (see R00936)

natural substrates

4.1.3.38

aminodeoxychorismate lyase

4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate

: tetrahydrofolate metabolism

: Folate biosynthesis

: 4-aminobenzoate biosynthesis

: BR47975

: R05553

: ADCLY-RXN

: ADC Lyase, PabC see R01716

natural substrates

6.3.2.12

dihydrofolate synthase

ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate

: tetrahydrofolate metabolism

: Folate biosynthesis,
Metabolic pathways

: tetrahydrofolate biosynthesis

: BR104

: R02237

: DIHYDROFOLATESYNTH-RXN

natural substrates

6.3.2.17

tetrahydrofolate synthase

ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate

: tetrahydrofolate metabolism

: Folate biosynthesis,
Metabolic pathways

: tetrahydrofolate biosynthesis

: BR104

: R02237

: DIHYDROFOLATESYNTH-RXN

natural substrates

3.5.4.16

GTP cyclohydrolase I

GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate

: tetrahydrofolate metabolism

: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium),
drosopterin and aurodrosopterin biosynthesis,
tetrahydromonapterin biosynthesis,
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I,
threo-tetrahydrobiopterin biosynthesis,
preQ0 biosynthesis,
erythro-tetrahydrobiopterin biosynthesis II,
erythro-tetrahydrobiopterin biosynthesis I

: BR22737

: R00424

: GTP-CYCLOHYDRO-I-RXN

: 9177

: four-step reaction (see R00428+R05046+R05048+R04639)

natural substrates

2.5.1.15

dihydropteroate synthase

(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate

: tetrahydrofolate metabolism

: Folate biosynthesis,
Metabolic pathways

: tetrahydrofolate biosynthesis

: BR47663

: R03067

: H2PTEROATESYNTH-RXN

: 2910

natural substrates

6.3.3.2

5-formyltetrahydrofolate cyclo-ligase

ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methylenetetrahydrofolate

: tetrahydrofolate metabolism

: BS638