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BRENDA KEGG MetaCyc

tetrahydrofolate metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
6,7-dihydropteridine reductase
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+
BR51347 show the reaction diagram
R11019 show the reaction diagram
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natural substrates
dihydromonapterin reductase
5,6,7,8-tetrahydromonapterin + NADP+ = 7,8-dihydromonapterin + NADPH + H+
BR51347 show the reaction diagram
R11019 show the reaction diagram
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natural substrates
dihydroneopterin triphosphate 2'-epimerase
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
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natural substrates
7,8-dihydroneopterin epimerase
7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate
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natural substrates
7-cyano-7-deazaguanine synthase
7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O
BR50022 show the reaction diagram
R09978 show the reaction diagram
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natural substrates
7-carboxy-7-deazaguanine synthase
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3
BR50129 show the reaction diagram
R10002 show the reaction diagram
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: radical SAM
natural substrates
6-carboxytetrahydropterin synthase
7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
BR50066 show the reaction diagram
R09959 show the reaction diagram
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: multi-step reaction possibly intermediate (see [CPD:C03684], R04286)
natural substrates, multi-step reaction
formyltetrahydrofolate deformylase
10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate
BR22680 show the reaction diagram
R00944 show the reaction diagram
1259
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natural substrates
methylenetetrahydrofolate reductase [NAD(P)H]
5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH + H+
BR36896 show the reaction diagram
R01224 show the reaction diagram
1453
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natural substrates
aminodeoxychorismate synthase
chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate
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: two-step reaction (see R00256 + R05552)
natural substrates
phosphoribosylglycinamide formyltransferase
10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
BR43941 show the reaction diagram
R04325 show the reaction diagram
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natural substrates
dihydrofolate reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
BR36900 show the reaction diagram
R00939 show the reaction diagram
100
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: NADH (see R00936)
natural substrates
pteridine reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
BR36900 show the reaction diagram
R00939 show the reaction diagram
100
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: NADH (see R00936)
natural substrates
6,7-dihydropteridine reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
BR36900 show the reaction diagram
R00939 show the reaction diagram
100
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: NADH (see R00936)
natural substrates
methylenetetrahydrofolate dehydrogenase (NADP+)
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
BR36900 show the reaction diagram
R00939 show the reaction diagram
100
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: NADH (see R00936)
natural substrates
dihydromonapterin reductase
5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
BR36900 show the reaction diagram
R00939 show the reaction diagram
100
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: NADH (see R00936)
natural substrates
aminodeoxychorismate lyase
4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate
BR47975 show the reaction diagram
R05553 show the reaction diagram
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: ADC Lyase, PabC see R01716
natural substrates
dihydrofolate synthase
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
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natural substrates
tetrahydrofolate synthase
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
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natural substrates
dihydropteroate synthase
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + 7,8-dihydropteroate
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natural substrates
5-formyltetrahydrofolate cyclo-ligase
ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methylenetetrahydrofolate
BS638 show the reaction diagram
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