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BRENDA KEGG MetaCyc

tryptophan metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
tryptophan-phenylpyruvate transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
BR50308 show the reaction diagram
R10180 show the reaction diagram
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natural substrates
alanine-glyoxylate transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
BR50308 show the reaction diagram
R10180 show the reaction diagram
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natural substrates
tyrosine transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
BR50308 show the reaction diagram
R10180 show the reaction diagram
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natural substrates
serine-pyruvate transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
BR50308 show the reaction diagram
R10180 show the reaction diagram
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natural substrates
aromatic-amino-acid transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
BR50308 show the reaction diagram
R10180 show the reaction diagram
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natural substrates
glutamine-phenylpyruvate transaminase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
BR50308 show the reaction diagram
R10180 show the reaction diagram
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natural substrates
L-tryptophan-pyruvate aminotransferase
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine
BR50308 show the reaction diagram
R10180 show the reaction diagram
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natural substrates
anthranilate 3-monooxygenase (FAD)
anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O
BR49368 show the reaction diagram
R09517 show the reaction diagram
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natural substrates
tryptophan-phenylpyruvate transaminase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
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natural substrates
aromatic-amino-acid transaminase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
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natural substrates
glutamine-phenylpyruvate transaminase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
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natural substrates
aspartate-phenylpyruvate transaminase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
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natural substrates
L-tryptophan-pyruvate aminotransferase
L-tryptophan + phenylpyruvate = (indol-3-yl)pyruvate + L-phenylalanine
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natural substrates
pyruvate decarboxylase
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2
BR335 show the reaction diagram
R01974 show the reaction diagram
2017
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natural substrates
phenylpyruvate decarboxylase
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2
BR335 show the reaction diagram
R01974 show the reaction diagram
2017
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natural substrates
branched-chain-2-oxoacid decarboxylase
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2
BR335 show the reaction diagram
R01974 show the reaction diagram
2017
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natural substrates
indolepyruvate decarboxylase
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2
BR335 show the reaction diagram
R01974 show the reaction diagram
2017
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natural substrates
(indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+
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natural substrates
indole-3-acetaldehyde reductase (NADPH)
(indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+
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natural substrates
alcohol dehydrogenase (NADP+)
(indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+
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natural substrates
aldehyde reductase
(indol-3-yl)ethanol + NADP+ = (indol-3-yl)acetaldehyde + NADPH + H+
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natural substrates
tryptophan 2'-dioxygenase
L-tryptophan + O2 = (indol-3-yl)glycolaldehyde + CO2 + NH3
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natural substrates
acetyl-CoA C-acetyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
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natural substrates
acetyl-CoA C-myristoyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
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natural substrates
acetyl-CoA C-acyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
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natural substrates
[acyl-carrier-protein] S-acetyltransferase
2 acetyl-CoA = CoA + acetoacetyl-CoA
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natural substrates
hydroxymethylglutaryl-CoA reductase (NADPH)
2 acetyl-CoA = CoA + acetoacetyl-CoA
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natural substrates
3-hydroxy-2-methylbutyryl-CoA dehydrogenase
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
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natural substrates
long-chain-3-hydroxyacyl-CoA dehydrogenase
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
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natural substrates
3-oxoacyl-[acyl-carrier-protein] reductase (NADH)
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
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natural substrates
3-hydroxyacyl-CoA dehydrogenase
3-hydroxybutyryl-CoA + NAD+ = acetoacetyl-CoA + NADH
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natural substrates
glutaconyl-CoA decarboxylase
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2
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: following after R10074 (ec 1.3.8.6) requires Na+ and acts as a sodium pump (ec 4.1.1.70)
natural substrates
glutaryl-CoA dehydrogenase (ETF)
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2
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: following after R10074 (ec 1.3.8.6) requires Na+ and acts as a sodium pump (ec 4.1.1.70)
natural substrates
methylcrotonoyl-CoA carboxylase
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2
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: following after R10074 (ec 1.3.8.6) requires Na+ and acts as a sodium pump (ec 4.1.1.70)
natural substrates
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2
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: following after R10074 (ec 1.3.8.6) requires Na+ and acts as a sodium pump (ec 4.1.1.70)
natural substrates
tryptophanase
L-tryptophan + H2O = indole + pyruvate + NH3
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: multi-step reaction intermediate (2-aminoacrylate Schiff base with PLP)
natural substrates, multi-step reaction
anthranilate phosphoribosyltransferase
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
phosphoribosylanthranilate isomerase
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
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natural substrates
indole-3-glycerol-phosphate synthase
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
BR307 show the reaction diagram
R03508 show the reaction diagram
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natural substrates
indole-3-glycerol-phosphate lyase
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
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: a part of multi-step reaction (ec 4.2.1.20, see R02722, R02340+R00674)
natural substrates
tryptophan synthase
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
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: a part of multi-step reaction (ec 4.2.1.20, see R02722, R02340+R00674)
natural substrates
tryptophanase
L-serine + indole = L-tryptophan + H2O
BR49621 show the reaction diagram
R00674 show the reaction diagram
1054
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: multi-step reaction intermediate (2-aminoacrylate Schiff base with PLP)
natural substrates, multi-step reaction
tryptophan synthase (indole-salvaging)
L-serine + indole = L-tryptophan + H2O
BR49621 show the reaction diagram
R00674 show the reaction diagram
1054
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: multi-step reaction intermediate (2-aminoacrylate Schiff base with PLP)
natural substrates, multi-step reaction
tryptophan synthase
L-serine + indole = L-tryptophan + H2O
BR49621 show the reaction diagram
R00674 show the reaction diagram
1054
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: multi-step reaction intermediate (2-aminoacrylate Schiff base with PLP)
natural substrates, multi-step reaction
aromatic 2-oxoacid reductase
(R)-(Indol-3-yl)lactate + NAD+ <=> Indolepyruvate + NADH + H+
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natural substrates
putrescine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
R02173 show the reaction diagram
2147
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natural substrates
primary-amine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
R02173 show the reaction diagram
2147
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natural substrates
diamine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
R02173 show the reaction diagram
2147
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natural substrates
monoamine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
R02173 show the reaction diagram
2147
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natural substrates
pyridoxal 5'-phosphate synthase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
R02173 show the reaction diagram
2147
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natural substrates
non-specific polyamine oxidase
tryptamine + H2O + O2 = 1H-indol-3-yl-acetaldehyde + NH3 + H2O2
R02173 show the reaction diagram
2147
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natural substrates
aldehyde oxidase
(indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2
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natural substrates
indole-3-acetaldehyde oxidase
(indol-3-yl)acetaldehyde + H2O + O2 = (indol-3-yl)acetate + H2O2
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natural substrates
(indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+
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natural substrates
alcohol dehydrogenase
(indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+
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natural substrates
indole-3-acetaldehyde reductase (NADH)
(indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+
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natural substrates
aldehyde reductase
(indol-3-yl)ethanol + NAD+ = (indol-3-yl)acetaldehyde + NADH + H+
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natural substrates
2-aminomuconate deaminase (2-hydroxymuconate-forming)
2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3
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natural substrates
2-aminomuconate deaminase
2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3
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natural substrates
2-oxo-3-hexenedioate decarboxylase
4-Oxalocrotonate = 2-Oxopent-4-enoate + CO2
BS1617 show the reaction diagram
R02602 show the reaction diagram
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natural substrates
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
(indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
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natural substrates, generic, protein
indolepyruvate ferredoxin oxidoreductase
(indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
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natural substrates, generic, protein
tryptophan-tRNA ligase
ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophyl-tRNATrp
BR50 show the reaction diagram
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natural substrates, generic, nucleotide
kynurenine-oxoglutarate transaminase
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
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: subsequently R03445 (non-enzymatic cyclizing)
natural substrates
cysteine-conjugate transaminase
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
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: subsequently R03445 (non-enzymatic cyclizing)
natural substrates
cyclopeptine synthase
2 ATP + S-adenosyl-L-methionine + anthranilate + L-phenylalanine = cyclopeptine + 2 AMP + 2 diphosphate + S-adenosyl-L-homocysteine
BR50555 show the reaction diagram
R10495 show the reaction diagram
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natural substrates