Pathways

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BRENDA KEGG MetaCyc

urea cycle (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
L-ornithine N5-monooxygenase (NADPH)
L-ornithine + NADPH + H+ + O2 = N5-hydroxy-L-ornithine + NADP+ + H2O
: urea cycle
: ferrichrome A biosynthesis,
pyoverdine I biosynthesis
: BR49228 show the reaction diagram
: R10789 show the reaction diagram
: RXN-11128 show the reaction diagram, RXN-13783 show the reaction diagram
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natural substrates
L-ornithine N5-monooxygenase [NAD(P)H]
L-ornithine + NADPH + H+ + O2 = N5-hydroxy-L-ornithine + NADP+ + H2O
: urea cycle
: ferrichrome A biosynthesis,
pyoverdine I biosynthesis
: BR49228 show the reaction diagram
: R10789 show the reaction diagram
: RXN-11128 show the reaction diagram, RXN-13783 show the reaction diagram
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natural substrates
2-amino-4-oxopentanoate thiolase
acetyl-CoA + D-alanine = CoA + (2R)-2-amino-4-oxopentanoate
: urea cycle
: L-ornithine degradation II (Stickland reaction)
: BR49308 show the reaction diagram, BS407182 show the reaction diagram
: R00399 show the reaction diagram
: AKPTHIOL-RXN show the reaction diagram
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natural substrates
2,4-diaminopentanoate dehydrogenase
(2R,4S)-2,4-diaminopentanoate + H2O + NADP+ = (2R)-2-amino-4-oxopentanoate + NH3 + NADPH + H+
: urea cycle
: D-Arginine and D-ornithine metabolism
: L-ornithine degradation II (Stickland reaction)
: BR36860 show the reaction diagram, BS258906 show the reaction diagram
: R04201 show the reaction diagram
: 24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN show the reaction diagram
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: R04200 (NAD)
natural substrates
D-ornithine 4,5-aminomutase
D-ornithine = (2R,4S)-2,4-diaminopentanoate
: urea cycle
: D-Arginine and D-ornithine metabolism
: L-ornithine degradation II (Stickland reaction)
: BR29 show the reaction diagram
: R02461 show the reaction diagram
: ORNMUTST-RXN show the reaction diagram
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natural substrates
amino-acid racemase
L-ornithine = D-ornithine
: urea cycle
: D-Arginine and D-ornithine metabolism,
Metabolic pathways
: L-ornithine degradation II (Stickland reaction),
staphyloferrin A biosynthesis
: BR165 show the reaction diagram
: R00672 show the reaction diagram
: ORNITHINE-RACEMASE-RXN show the reaction diagram
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natural substrates
ornithine racemase
L-ornithine = D-ornithine
: urea cycle
: D-Arginine and D-ornithine metabolism,
Metabolic pathways
: L-ornithine degradation II (Stickland reaction),
staphyloferrin A biosynthesis
: BR165 show the reaction diagram
: R00672 show the reaction diagram
: ORNITHINE-RACEMASE-RXN show the reaction diagram
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natural substrates
lysine racemase
L-ornithine = D-ornithine
: urea cycle
: D-Arginine and D-ornithine metabolism,
Metabolic pathways
: L-ornithine degradation II (Stickland reaction),
staphyloferrin A biosynthesis
: BR165 show the reaction diagram
: R00672 show the reaction diagram
: ORNITHINE-RACEMASE-RXN show the reaction diagram
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natural substrates
arginine racemase
L-ornithine = D-ornithine
: urea cycle
: D-Arginine and D-ornithine metabolism,
Metabolic pathways
: L-ornithine degradation II (Stickland reaction),
staphyloferrin A biosynthesis
: BR165 show the reaction diagram
: R00672 show the reaction diagram
: ORNITHINE-RACEMASE-RXN show the reaction diagram
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natural substrates
urea carboxylase
ATP + urea + HCO3- + H+ = ADP + phosphate + urea-1-carboxylate
: urea cycle
: Arginine biosynthesis,
Atrazine degradation,
Metabolic pathways
: BR143 show the reaction diagram
: R00774 show the reaction diagram
: 1126
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natural substrates
allophanate hydrolase
urea-1-carboxylate + H2O = 2 CO2 + 2 NH3
: urea cycle
: Arginine biosynthesis,
Atrazine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: BR22698 show the reaction diagram
: R00005 show the reaction diagram
: ALLOPHANATE-HYDROLASE-RXN show the reaction diagram
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: The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 6.3.4.6 urea carboxylase, thus bringing about the hydrolysis of urea to CO2 and NH3 in the presence of ATP and bicarbonate. R00774 (6.3.4.6)
natural substrates
arginase
L-arginine + H2O = L-ornithine + urea
: arginine metabolism,
urea cycle
: Arginine biosynthesis,
Arginine and proline metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
: L-Ndelta-acetylornithine biosynthesis,
L-citrulline biosynthesis,
L-arginine degradation I (arginase pathway),
putrescine biosynthesis IV,
L-arginine degradation VII (arginase 3 pathway),
L-arginine degradation VI (arginase 2 pathway),
urea cycle
: BR19260 show the reaction diagram, BS140960 show the reaction diagram
: R00551 show the reaction diagram
: ARGINASE-RXN show the reaction diagram
: 574
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natural substrates
guanidinobutyrase
L-arginine + H2O = L-ornithine + urea
: arginine metabolism,
urea cycle
: Arginine biosynthesis,
Arginine and proline metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
: L-Ndelta-acetylornithine biosynthesis,
L-citrulline biosynthesis,
L-arginine degradation I (arginase pathway),
putrescine biosynthesis IV,
L-arginine degradation VII (arginase 3 pathway),
L-arginine degradation VI (arginase 2 pathway),
urea cycle
: BR19260 show the reaction diagram, BS140960 show the reaction diagram
: R00551 show the reaction diagram
: ARGINASE-RXN show the reaction diagram
: 574
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natural substrates
argininosuccinate lyase
2-(Nomega-L-arginino)succinate = fumarate + L-arginine
: urea cycle,
arginine metabolism
: Arginine biosynthesis,
Alanine, aspartate and glutamate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
: L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis III (via N-acetyl-L-citrulline),
L-arginine biosynthesis II (acetyl cycle),
L-arginine biosynthesis I (via L-ornithine),
urea cycle,
nitric oxide biosynthesis II (mammals)
: BR3431 show the reaction diagram
: R01086 show the reaction diagram
: ARGSUCCINLYA-RXN show the reaction diagram
: 573
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natural substrates
adenylosuccinate lyase
2-(Nomega-L-arginino)succinate = fumarate + L-arginine
: urea cycle,
arginine metabolism
: Arginine biosynthesis,
Alanine, aspartate and glutamate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
: L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis III (via N-acetyl-L-citrulline),
L-arginine biosynthesis II (acetyl cycle),
L-arginine biosynthesis I (via L-ornithine),
urea cycle,
nitric oxide biosynthesis II (mammals)
: BR3431 show the reaction diagram
: R01086 show the reaction diagram
: ARGSUCCINLYA-RXN show the reaction diagram
: 573
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natural substrates
ornithine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: urea cycle
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
: L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis II (acetyl cycle),
L-arginine biosynthesis I (via L-ornithine),
urea cycle,
L-proline biosynthesis II (from arginine)
: BR43950 show the reaction diagram, BS140887 show the reaction diagram
: R01398 show the reaction diagram
: ORNCARBAMTRANSFER-RXN show the reaction diagram, RXN-13482 show the reaction diagram
: 98
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natural substrates
putrescine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: urea cycle
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
: L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis II (acetyl cycle),
L-arginine biosynthesis I (via L-ornithine),
urea cycle,
L-proline biosynthesis II (from arginine)
: BR43950 show the reaction diagram, BS140887 show the reaction diagram
: R01398 show the reaction diagram
: ORNCARBAMTRANSFER-RXN show the reaction diagram, RXN-13482 show the reaction diagram
: 98
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natural substrates
agmatine deiminase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: urea cycle
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
: L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis II (acetyl cycle),
L-arginine biosynthesis I (via L-ornithine),
urea cycle,
L-proline biosynthesis II (from arginine)
: BR43950 show the reaction diagram, BS140887 show the reaction diagram
: R01398 show the reaction diagram
: ORNCARBAMTRANSFER-RXN show the reaction diagram, RXN-13482 show the reaction diagram
: 98
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natural substrates
argininosuccinate synthase
ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate
: urea cycle
: Arginine biosynthesis,
Alanine, aspartate and glutamate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of antibiotics,
Biosynthesis of amino acids
: L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis III (via N-acetyl-L-citrulline),
L-arginine biosynthesis II (acetyl cycle),
L-arginine biosynthesis I (via L-ornithine),
urea cycle,
nitric oxide biosynthesis II (mammals)
: BR142 show the reaction diagram, BS408483 show the reaction diagram
: R01954 show the reaction diagram
: ARGSUCCINSYN-RXN show the reaction diagram
: 572
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natural substrates
carbamate kinase
ATP + NH3 + hydrogencarbonate = ADP + carbamoyl phosphate + H2O
: urea cycle
: Arginine biosynthesis,
Purine metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: BR47825 show the reaction diagram
: R00150 show the reaction diagram
: CARBAMATE-KINASE-RXN show the reaction diagram
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: two-step reaction (see R01395+R12185)
natural substrates
urease
urea + H2O = CO2 + 2 NH3
: urea cycle
: Arginine biosynthesis,
Purine metabolism,
Atrazine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: urea degradation II
: BR22694 show the reaction diagram
: R00131 show the reaction diagram
: UREASE-RXN show the reaction diagram
: 289
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natural substrates