urease
Pathways
urea cycle (BRENDA)






EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
urea + H2O = CO2 + 2 NH3
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natural substrates
carbamate kinase
ATP + NH3 + hydrogencarbonate = ADP + carbamoyl phosphate + H2O
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natural substrates
argininosuccinate synthase
ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate
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natural substrates
ornithine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids

L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis II (acetyl cycle),
urea cycle
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natural substrates
putrescine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids

L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis II (acetyl cycle),
urea cycle
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natural substrates
agmatine deiminase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids

L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis II (acetyl cycle),
urea cycle
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natural substrates
citrullinase
L-citrulline + H2O = L-ornithine + CO2 + NH3
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natural substrates
beta-ureidopropionase
L-citrulline + H2O = L-ornithine + CO2 + NH3
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natural substrates
argininosuccinate lyase
2-(Nomega-L-arginino)succinate = fumarate + L-arginine
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natural substrates
adenylosuccinate lyase
2-(Nomega-L-arginino)succinate = fumarate + L-arginine
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natural substrates
arginase
L-arginine + H2O = L-ornithine + urea
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natural substrates
guanidinobutyrase
L-arginine + H2O = L-ornithine + urea
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natural substrates
allophanate hydrolase
urea-1-carboxylate + H2O = 2 CO2 + 2 NH3
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natural substrates
urea carboxylase
ATP + urea + HCO3- + H+ = ADP + phosphate + urea-1-carboxylate
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natural substrates