Pathways

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BRENDA KEGG MetaCyc

urea cycle (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
urease
urea + H2O = CO2 + 2 NH3
: urea cycle
: Arginine biosynthesis,
Purine metabolism,
Atrazine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: urea degradation II
: BR22694show the reaction diagram
: R00131show the reaction diagram
: UREASE-RXNshow the reaction diagram
: 289
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-
natural substrates
carbamate kinase
ATP + NH3 + hydrogencarbonate = ADP + carbamoyl phosphate + H2O
: urea cycle
: Arginine biosynthesis,
Purine metabolism,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism
: BR47825show the reaction diagram
: R00150show the reaction diagram
: CARBAMATE-KINASE-RXNshow the reaction diagram
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: two-step reaction (see R01395+R12185)
natural substrates
argininosuccinate synthase
ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate
: urea cycle
: Arginine biosynthesis,
Alanine, aspartate and glutamate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine biosynthesis I (via L-ornithine),
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis III (via N-acetyl-L-citrulline),
L-arginine biosynthesis II (acetyl cycle),
urea cycle,
nitric oxide biosynthesis II (mammals)
: BR142show the reaction diagram, BS408483show the reaction diagram
: R01954show the reaction diagram
: ARGSUCCINSYN-RXNshow the reaction diagram
: 572
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natural substrates
ornithine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: urea cycle
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis II (acetyl cycle),
urea cycle
: BR43950show the reaction diagram, BS140887show the reaction diagram
: R01398show the reaction diagram
: ORNCARBAMTRANSFER-RXNshow the reaction diagram, RXN-13482show the reaction diagram
: 98
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natural substrates
putrescine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: urea cycle
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis II (acetyl cycle),
urea cycle
: BR43950show the reaction diagram, BS140887show the reaction diagram
: R01398show the reaction diagram
: ORNCARBAMTRANSFER-RXNshow the reaction diagram, RXN-13482show the reaction diagram
: 98
-
-
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-
natural substrates
agmatine deiminase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: urea cycle
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis II (acetyl cycle),
urea cycle
: BR43950show the reaction diagram, BS140887show the reaction diagram
: R01398show the reaction diagram
: ORNCARBAMTRANSFER-RXNshow the reaction diagram, RXN-13482show the reaction diagram
: 98
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natural substrates
citrullinase
L-citrulline + H2O = L-ornithine + CO2 + NH3
: urea cycle
: BR19238show the reaction diagram, BS116217show the reaction diagram
: R00665show the reaction diagram
: CITRULLINASE-RXNshow the reaction diagram
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natural substrates
beta-ureidopropionase
L-citrulline + H2O = L-ornithine + CO2 + NH3
: urea cycle
: BR19238show the reaction diagram, BS116217show the reaction diagram
: R00665show the reaction diagram
: CITRULLINASE-RXNshow the reaction diagram
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natural substrates
argininosuccinate lyase
2-(Nomega-L-arginino)succinate = fumarate + L-arginine
: arginine metabolism,
urea cycle
: Arginine biosynthesis,
Alanine, aspartate and glutamate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine biosynthesis I (via L-ornithine),
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis III (via N-acetyl-L-citrulline),
L-arginine biosynthesis II (acetyl cycle),
urea cycle,
nitric oxide biosynthesis II (mammals)
: BR3431show the reaction diagram
: R01086show the reaction diagram
: ARGSUCCINLYA-RXNshow the reaction diagram
: 573
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natural substrates
adenylosuccinate lyase
2-(Nomega-L-arginino)succinate = fumarate + L-arginine
: arginine metabolism,
urea cycle
: Arginine biosynthesis,
Alanine, aspartate and glutamate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine biosynthesis I (via L-ornithine),
L-arginine biosynthesis IV (archaebacteria),
L-arginine biosynthesis III (via N-acetyl-L-citrulline),
L-arginine biosynthesis II (acetyl cycle),
urea cycle,
nitric oxide biosynthesis II (mammals)
: BR3431show the reaction diagram
: R01086show the reaction diagram
: ARGSUCCINLYA-RXNshow the reaction diagram
: 573
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-
natural substrates
arginase
L-arginine + H2O = L-ornithine + urea
: urea cycle,
arginine metabolism
: Arginine biosynthesis,
Arginine and proline metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: putrescine biosynthesis III,
L-Ndelta-acetylornithine biosynthesis,
L-citrulline biosynthesis,
L-arginine degradation I (arginase pathway),
L-arginine degradation VII (arginase 3 pathway),
L-arginine degradation VI (arginase 2 pathway),
urea cycle
: BR19260show the reaction diagram, BS140960show the reaction diagram
: R00551show the reaction diagram
: ARGINASE-RXNshow the reaction diagram
: 574
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natural substrates
guanidinobutyrase
L-arginine + H2O = L-ornithine + urea
: urea cycle,
arginine metabolism
: Arginine biosynthesis,
Arginine and proline metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: putrescine biosynthesis III,
L-Ndelta-acetylornithine biosynthesis,
L-citrulline biosynthesis,
L-arginine degradation I (arginase pathway),
L-arginine degradation VII (arginase 3 pathway),
L-arginine degradation VI (arginase 2 pathway),
urea cycle
: BR19260show the reaction diagram, BS140960show the reaction diagram
: R00551show the reaction diagram
: ARGINASE-RXNshow the reaction diagram
: 574
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natural substrates
allophanate hydrolase
urea-1-carboxylate + H2O = 2 CO2 + 2 NH3
: urea cycle
: Arginine biosynthesis,
Atrazine degradation,
Metabolic pathways,
Microbial metabolism in diverse environments
: BR22698show the reaction diagram
: R00005show the reaction diagram
: ALLOPHANATE-HYDROLASE-RXNshow the reaction diagram
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: The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 6.3.4.6 urea carboxylase, thus bringing about the hydrolysis of urea to CO2 and NH3 in the presence of ATP and bicarbonate. R00774 (6.3.4.6)
natural substrates
urea carboxylase
ATP + urea + HCO3- + H+ = ADP + phosphate + urea-1-carboxylate
: urea cycle
: Arginine biosynthesis,
Atrazine degradation,
Metabolic pathways
: BR143show the reaction diagram
: R00774show the reaction diagram
: 1126
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natural substrates