Pathways

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BRENDA KEGG MetaCyc

valine metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
dihydroxy-acid dehydratase
2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O
R01209 show the reaction diagram
1442
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natural substrates
ketol-acid reductoisomerase [NAD(P)+]
(S)-2-acetolactate + NADPH + H+ = 2,3-dihydroxy-3-methylbutanoate + NADP+
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ketol-acid reductoisomerase (NADP+)
(S)-2-acetolactate + NADPH + H+ = 2,3-dihydroxy-3-methylbutanoate + NADP+
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2-oxoisovalerate dehydrogenase (acylating)
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH + H+
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: multi-step reaction possibly identical to branched-chain alpha-keto acid dehydrogenase complex (see R01701+R02662+R07618)
natural substrates, multi-step reaction
pyruvate dehydrogenase (acetyl-transferring)
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH + H+
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: multi-step reaction possibly identical to branched-chain alpha-keto acid dehydrogenase complex (see R01701+R02662+R07618)
natural substrates, multi-step reaction
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH + H+
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: multi-step reaction possibly identical to branched-chain alpha-keto acid dehydrogenase complex (see R01701+R02662+R07618)
natural substrates, multi-step reaction
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH + H+
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: multi-step reaction possibly identical to branched-chain alpha-keto acid dehydrogenase complex (see R01701+R02662+R07618)
natural substrates, multi-step reaction
3-hydroxyisobutyryl-CoA hydrolase
3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate
BR11729 show the reaction diagram
R03352 show the reaction diagram
3159
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natural substrates
3-hydroxyisobutyrate dehydrogenase
3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+
BR29294 show the reaction diagram
R02047 show the reaction diagram
2065
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natural substrates
3-hydroxypropionate dehydrogenase
3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+
BR29294 show the reaction diagram
R02047 show the reaction diagram
2065
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natural substrates
methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH
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natural substrates
pyruvate decarboxylase
2-oxoisopentanoate = CO2 + isobutanal
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natural substrates
benzoylformate decarboxylase
2-oxoisopentanoate = CO2 + isobutanal
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natural substrates
branched-chain-2-oxoacid decarboxylase
2-oxoisopentanoate = CO2 + isobutanal
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natural substrates
acetolactate synthase
2-oxoisopentanoate = CO2 + isobutanal
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natural substrates
alcohol dehydrogenase
2-methylpropan-1-ol + NAD+ = 2-methyl-propan-1-one + NADH
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natural substrates
cyclohexanol dehydrogenase
2-methylpropan-1-ol + NAD+ = 2-methyl-propan-1-one + NADH
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natural substrates
valine-tRNA ligase
ATP + L-valine + tRNAVal = AMP + diphosphate + L-valyl-tRNAVal
BR59 show the reaction diagram
R03665 show the reaction diagram
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natural substrates, nucleotide