Pathways

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BRENDA KEGG MetaCyc

valine metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
2-aminoadipate transaminase
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate
: valine metabolism,
alanine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Pantothenate and CoA biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids,
Biosynthesis of cofactors
: L-valine degradation III (oxidative Stickland reaction),
even iso-branched-chain fatty acid biosynthesis,
L-alanine biosynthesis I,
L-valine degradation I,
L-valine biosynthesis,
L-valine degradation II
: BS356553show the reaction diagram
: R01214show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERVAL-RXNshow the reaction diagram
: 1446
-
-
-
: Also acts on L-isoleucine and L-leucine.
natural substrates
branched-chain-amino-acid transaminase
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate
: valine metabolism,
alanine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Pantothenate and CoA biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids,
Biosynthesis of cofactors
: L-valine degradation III (oxidative Stickland reaction),
even iso-branched-chain fatty acid biosynthesis,
L-alanine biosynthesis I,
L-valine degradation I,
L-valine biosynthesis,
L-valine degradation II
: BS356553show the reaction diagram
: R01214show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERVAL-RXNshow the reaction diagram
: 1446
-
-
-
: Also acts on L-isoleucine and L-leucine.
natural substrates
leucine transaminase
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate
: valine metabolism,
alanine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Pantothenate and CoA biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids,
Biosynthesis of cofactors
: L-valine degradation III (oxidative Stickland reaction),
even iso-branched-chain fatty acid biosynthesis,
L-alanine biosynthesis I,
L-valine degradation I,
L-valine biosynthesis,
L-valine degradation II
: BS356553show the reaction diagram
: R01214show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERVAL-RXNshow the reaction diagram
: 1446
-
-
-
: Also acts on L-isoleucine and L-leucine.
natural substrates
valine-pyruvate transaminase
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate
: valine metabolism,
alanine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Pantothenate and CoA biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids,
Biosynthesis of cofactors
: L-valine degradation III (oxidative Stickland reaction),
even iso-branched-chain fatty acid biosynthesis,
L-alanine biosynthesis I,
L-valine degradation I,
L-valine biosynthesis,
L-valine degradation II
: BS356553show the reaction diagram
: R01214show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERVAL-RXNshow the reaction diagram
: 1446
-
-
-
: Also acts on L-isoleucine and L-leucine.
natural substrates
(R)-amine:2-oxo acid transaminase
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate
: valine metabolism,
alanine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Pantothenate and CoA biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids,
Biosynthesis of cofactors
: L-valine degradation III (oxidative Stickland reaction),
even iso-branched-chain fatty acid biosynthesis,
L-alanine biosynthesis I,
L-valine degradation I,
L-valine biosynthesis,
L-valine degradation II
: BS356553show the reaction diagram
: R01214show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERVAL-RXNshow the reaction diagram
: 1446
-
-
-
: Also acts on L-isoleucine and L-leucine.
natural substrates
dihydroxy-acid dehydratase
2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O
: valine metabolism
: BR3406show the reaction diagram, BS402320show the reaction diagram
: R01209show the reaction diagram
: 1442
-
-
-
-
natural substrates
ketol-acid reductoisomerase [NAD(P)+]
(S)-2-acetolactate + NADPH + H+ = 2,3-dihydroxy-3-methylbutanoate + NADP+
: valine metabolism
: BS436670show the reaction diagram
-
-
-
-
-
ketol-acid reductoisomerase (NADP+)
(S)-2-acetolactate + NADPH + H+ = 2,3-dihydroxy-3-methylbutanoate + NADP+
: valine metabolism
: BS436670show the reaction diagram
-
-
-
-
-
pyruvate decarboxylase
2 pyruvate = 2-acetolactate + CO2
: valine metabolism,
acetoin degradation
: Valine, leucine and isoleucine biosynthesis,
Butanoate metabolism,
C5-Branched dibasic acid metabolism,
Pantothenate and CoA biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-valine biosynthesis,
pyruvate fermentation to isobutanol (engineered),
pyruvate fermentation to (S)-acetoin,
pyruvate fermentation to (R)-acetoin I,
pyruvate fermentation to (R)-acetoin II
: BR37100show the reaction diagram, BS386675show the reaction diagram
: R00006show the reaction diagram, R00226show the reaction diagram
: ACETOLACTSYN-RXNshow the reaction diagram
: 6473, 749
-
-
-
: TPP-dependent enzymatic reaction (R00014+R03050); TPP-dependent enzymatic reaction (R00014+R04672)
natural substrates
acetolactate synthase
2 pyruvate = 2-acetolactate + CO2
: valine metabolism,
acetoin degradation
: Valine, leucine and isoleucine biosynthesis,
Butanoate metabolism,
C5-Branched dibasic acid metabolism,
Pantothenate and CoA biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-valine biosynthesis,
pyruvate fermentation to isobutanol (engineered),
pyruvate fermentation to (S)-acetoin,
pyruvate fermentation to (R)-acetoin I,
pyruvate fermentation to (R)-acetoin II
: BR37100show the reaction diagram, BS386675show the reaction diagram
: R00006show the reaction diagram, R00226show the reaction diagram
: ACETOLACTSYN-RXNshow the reaction diagram
: 6473, 749
-
-
-
: TPP-dependent enzymatic reaction (R00014+R03050); TPP-dependent enzymatic reaction (R00014+R04672)
natural substrates
pyruvate dehydrogenase system
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH + H+
: valine metabolism
: even iso-branched-chain fatty acid biosynthesis,
L-valine degradation I
: BR36775show the reaction diagram
: R01210show the reaction diagram
: 1.2.1.25-RXNshow the reaction diagram
: 1443
-
-
-
: multi-step reaction possibly identical to branched-chain alpha-keto acid dehydrogenase complex (see R01701+R02662+R07618)
natural substrates, multi-step reaction
branched-chain alpha-keto acid dehydrogenase system
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH + H+
: valine metabolism
: even iso-branched-chain fatty acid biosynthesis,
L-valine degradation I
: BR36775show the reaction diagram
: R01210show the reaction diagram
: 1.2.1.25-RXNshow the reaction diagram
: 1443
-
-
-
: multi-step reaction possibly identical to branched-chain alpha-keto acid dehydrogenase complex (see R01701+R02662+R07618)
natural substrates, multi-step reaction
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH + H+
: valine metabolism
: even iso-branched-chain fatty acid biosynthesis,
L-valine degradation I
: BR36775show the reaction diagram
: R01210show the reaction diagram
: 1.2.1.25-RXNshow the reaction diagram
: 1443
-
-
-
: multi-step reaction possibly identical to branched-chain alpha-keto acid dehydrogenase complex (see R01701+R02662+R07618)
natural substrates, multi-step reaction
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
3-methyl-2-oxobutanoate + CoA + NAD+ = 2-methylpropanoyl-CoA + CO2 + NADH + H+
: valine metabolism
: even iso-branched-chain fatty acid biosynthesis,
L-valine degradation I
: BR36775show the reaction diagram
: R01210show the reaction diagram
: 1.2.1.25-RXNshow the reaction diagram
: 1443
-
-
-
: multi-step reaction possibly identical to branched-chain alpha-keto acid dehydrogenase complex (see R01701+R02662+R07618)
natural substrates, multi-step reaction
short-chain 2-methylacyl-CoA dehydrogenase
isobutyryl-CoA + electron-transfer flavoprotein = 2-methylacryloyl-CoA + reduced electron-transfer flavoprotein + H+
: valine metabolism
: BS457028show the reaction diagram
-
-
-
-
-
enoyl-CoA hydratase
methacrylyl-CoA + H2O = 3-hydroxy-2-methylpropanoyl-CoA
: valine metabolism
: BS444368show the reaction diagram
-
-
-
-
natural substrates
3-hydroxyisobutyryl-CoA hydrolase
3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate
: valine metabolism
: BR11729show the reaction diagram
: R03352show the reaction diagram
: RXN-13721show the reaction diagram
: 3159
-
-
-
-
natural substrates
3-hydroxyisobutyrate dehydrogenase
3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+
: valine metabolism
: BR29294show the reaction diagram
: R02047show the reaction diagram
: 2065
-
-
-
-
natural substrates
3-hydroxypropionate dehydrogenase
3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+
: valine metabolism
: BR29294show the reaction diagram
: R02047show the reaction diagram
: 2065
-
-
-
-
natural substrates
methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH
: valine metabolism
: 2,4-dinitrotoluene degradation
: BR36776show the reaction diagram
: 1.2.1.27-RXNshow the reaction diagram
-
-
-
-
natural substrates
pyruvate decarboxylase
2-oxoisopentanoate = CO2 + isobutanal
: valine metabolism
: butanol and isobutanol biosynthesis (engineered),
pyruvate fermentation to isobutanol (engineered),
L-valine degradation II
: BS363283show the reaction diagram
: RXN-7643show the reaction diagram
-
-
-
-
natural substrates
benzoylformate decarboxylase
2-oxoisopentanoate = CO2 + isobutanal
: valine metabolism
: butanol and isobutanol biosynthesis (engineered),
pyruvate fermentation to isobutanol (engineered),
L-valine degradation II
: BS363283show the reaction diagram
: RXN-7643show the reaction diagram
-
-
-
-
natural substrates
branched-chain-2-oxoacid decarboxylase
2-oxoisopentanoate = CO2 + isobutanal
: valine metabolism
: butanol and isobutanol biosynthesis (engineered),
pyruvate fermentation to isobutanol (engineered),
L-valine degradation II
: BS363283show the reaction diagram
: RXN-7643show the reaction diagram
-
-
-
-
natural substrates
acetolactate synthase
2-oxoisopentanoate = CO2 + isobutanal
: valine metabolism
: butanol and isobutanol biosynthesis (engineered),
pyruvate fermentation to isobutanol (engineered),
L-valine degradation II
: BS363283show the reaction diagram
: RXN-7643show the reaction diagram
-
-
-
-
natural substrates
alcohol dehydrogenase
2-methylpropan-1-ol + NAD+ = 2-methyl-propan-1-one + NADH
: valine metabolism
: butanol and isobutanol biosynthesis (engineered),
pyruvate fermentation to isobutanol (engineered),
L-valine degradation II
: BS186845show the reaction diagram
: RXN-7657show the reaction diagram
: 9859
-
-
-
-
natural substrates
alcohol dehydrogenase (NADP+)
2-methylpropan-1-ol + NAD+ = 2-methyl-propan-1-one + NADH
: valine metabolism
: butanol and isobutanol biosynthesis (engineered),
pyruvate fermentation to isobutanol (engineered),
L-valine degradation II
: BS186845show the reaction diagram
: RXN-7657show the reaction diagram
: 9859
-
-
-
-
natural substrates
cyclohexanol dehydrogenase
2-methylpropan-1-ol + NAD+ = 2-methyl-propan-1-one + NADH
: valine metabolism
: butanol and isobutanol biosynthesis (engineered),
pyruvate fermentation to isobutanol (engineered),
L-valine degradation II
: BS186845show the reaction diagram
: RXN-7657show the reaction diagram
: 9859
-
-
-
-
natural substrates
valine-tRNA ligase
ATP + L-valine + tRNAVal = AMP + diphosphate + L-valyl-tRNAVal
: valine metabolism
: Aminoacyl-tRNA biosynthesis
: BR59show the reaction diagram
: R03665show the reaction diagram
: 416
-
-
-
-
natural substrates