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BRENDA KEGG MetaCyc

vitamin B1 metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
aminopyrimidine aminohydrolase
thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole
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natural substrates
hydroxyethylthiazole kinase
ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole
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natural substrates
phosphomethylpyrimidine synthase
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
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natural substrates
pyridoxal kinase
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
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natural substrates
hydroxymethylpyrimidine kinase
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
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natural substrates
phosphooxymethylpyrimidine kinase
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
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natural substrates
thiamine phosphate synthase
4-amino-2-methyl-5-(diphosphomethyl)pyrimidine + 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = diphosphate + thiamine phosphate + CO2
BR47665 show the reaction diagram
R11312 show the reaction diagram
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: Studies with the enzyme from Bacillus subtilis suggested that the preferred substrate for the enzyme in vivo is CPD-13576 [21534620]. However, the enzyme also accepts |FRAME:THZ-P| with similar efficiency.
natural substrates
dihydrolipoyllysine-residue succinyltransferase
succinyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-succinyldihydrolipoyl)lysine
BR44062 show the reaction diagram
R02570 show the reaction diagram
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: 2-oxoglutarate dehydrogenase complex:dihydrolipoyllysine-residue succinyltransferase a part of multi-step reaction (see R08549, R01700+R02570+R07618) following after R01700
natural substrates, protein
cysteine desulfurase
L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine
BR49765 show the reaction diagram
R07460 show the reaction diagram
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: [Enzyme] is the enzyme itself [KO:K04487].
natural substrates
cysteine desulfurase
[enzyme]-S-sulfanylcysteine + acceptor = [enzyme]-cysteine + S-sulfanyl-acceptor
BR49766 show the reaction diagram
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natural substrates, generic
sulfur carrier protein ThiS adenylyltransferase
ATP + [ThiS] = diphosphate + adenylyl-[ThiS]
BR49425 show the reaction diagram
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natural substrates, protein
2-iminoacetate synthase
L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+
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natural substrates
thiazole synthase
1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O
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natural substrates, protein
thiamine phosphate synthase
4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)thiazole = diphosphate + thiamine phosphate
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natural substrates