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BRENDA KEGG MetaCyc

vitamin B12 metabolism (BRENDA)

:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
precorrin-2 dehydrogenase
precorrin-2 + NAD+ = sirohydrochlorin + NADH + H+
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: multifunctional enzyme: siroheme synthase: precorrin-2 dehydrogenase (R03194+R03947+R02864) following after R03194, subsequently R02864
natural substrates
nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate + H+
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natural substrates
nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate + H+
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natural substrates
adenosylcobyric acid synthase (glutamine-hydrolysing)
4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate
BR48011 show the reaction diagram
R05225 show the reaction diagram
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: multi-step reaction
natural substrates, multi-step reaction
cob(I)yrinic acid a,c-diamide adenosyltransferase
ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide
R05220 show the reaction diagram
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natural substrates
cob(II)yrinic acid a,c-diamide reductase
2 cob(I)yrinic acid a,c-diamide + FMN + 2 H+ = 2 cob(II)yrinic acid a,c-diamide + FMNH2
BR47984 show the reaction diagram
R05218 show the reaction diagram
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natural substrates
adenosylcobinamide-phosphate synthase
ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate
BR48012 show the reaction diagram
R06529 show the reaction diagram
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natural substrates
S-adenosyl-L-methionine + cobalt-precorrin-3B = S-adenosyl-L-homocysteine + cobalt-precorrin-4
R05809 show the reaction diagram
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: multi-step reaction
natural substrates, multi-step reaction
precorrin-3B C17-methyltransferase
S-adenosyl-L-methionine + cobalt-precorrin-3B = S-adenosyl-L-homocysteine + cobalt-precorrin-4
R05809 show the reaction diagram
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: multi-step reaction
natural substrates, multi-step reaction
cobalt-precorrin-4 methyltransferase
Cobalt-precorrin 4 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 5A + S-Adenosyl-L-homocysteine
BR50534 show the reaction diagram
R05810 show the reaction diagram
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natural substrates
cobalt-factor II C20-methyltransferase
S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III
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natural substrates, protein
sirohydrochlorin cobaltochelatase
cobalt-sirohydrochlorin + 2 H+ = sirohydrochlorin + Co2+
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natural substrates
sirohydrochlorin ferrochelatase
cobalt-sirohydrochlorin + 2 H+ = sirohydrochlorin + Co2+
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natural substrates
cobalt-precorrin 5A hydrolase
cobalt-precorrin-5A + H2O = cobalt-precorrin-5B + acetaldehyde + 2 H+
BR49393 show the reaction diagram
R07772 show the reaction diagram
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natural substrates
cobalt-precorrin-6A reductase
cobalt-precorrin-6B + NAD+ = cobalt-precorrin-6A + NADH + H+
BR50935 show the reaction diagram
R05812 show the reaction diagram
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natural substrates
cobalt-precorrin-7 (C5)-methyltransferase
cobalt-precorrin-7 + S-adenosyl-L-methionine = cobalt-precorrin-8 + S-adenosyl-L-homocysteine
BR50788 show the reaction diagram
R07775 show the reaction diagram
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natural substrates
cobalt-precorrin-8 methylmutase
cobalt-precorrin-8 = cobyrinate
BR51009 show the reaction diagram
R05814 show the reaction diagram
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natural substrates
cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating]
cobalt-precorrin-6B + S-adenosyl-L-methionine + H+ = cobalt-precorrin-7 + S-adenosyl-L-homocysteine + CO2
BR49386 show the reaction diagram
R07774 show the reaction diagram
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: The enzyme from Pseudomonas denitrificans has S-adenosyl-L- methionine-dependent methyltransferase and decarboxylase activities.
natural substrates
cobalt-precorrin-5B (C1)-methyltransferase
cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine
BR49385 show the reaction diagram
R07773 show the reaction diagram
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natural substrates
cobyrinate a,c-diamide synthase
2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate
BR49510 show the reaction diagram
R05815 show the reaction diagram
6681
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: two-step reaction (see R09598+R09599)
natural substrates
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate
BR49510 show the reaction diagram
R05815 show the reaction diagram
6681
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: two-step reaction (see R09598+R09599)
natural substrates
2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate
BR49510 show the reaction diagram
R05815 show the reaction diagram
6681
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: two-step reaction (see R09598+R09599)
natural substrates
precorrin-3B synthase
precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O
BR47982 show the reaction diagram
R05217 show the reaction diagram
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: oxidoreduction, CobG, [Fe-S]
natural substrates
precorrin-3B C17-methyltransferase
S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4
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natural substrates
precorrin-4 C11-methyltransferase
S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5
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natural substrates
cobalt-precorrin-4 methyltransferase
S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5
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natural substrates
precorrin-2 C20-methyltransferase
S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A + H+
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natural substrates
precorrin-6A synthase (deacetylating)
S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate
BR47993 show the reaction diagram
R05219 show the reaction diagram
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natural substrates
precorrin-6B C5,15-methyltransferase (decarboxylating)
2 S-adenosyl-L-methionine + precorrin-6B = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2
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natural substrates
precorrin-6A reductase
precorrin-6B + NADP+ = precorrin-6A + NADPH + H+
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natural substrates
cobyrinate a,c-diamide synthase
2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate
BR48014 show the reaction diagram
R05224 show the reaction diagram
4835
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: multi-step reaction
natural substrates, multi-step reaction
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate
BR48014 show the reaction diagram
R05224 show the reaction diagram
4835
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: multi-step reaction
natural substrates, multi-step reaction
cobaltochelatase
ATP + hydrogenobyrinic acid a,c-diamide + Co2+ + H2O = ADP + phosphate + cob(II)yrinic acid a,c-diamide
BR48015 show the reaction diagram
R05227 show the reaction diagram
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natural substrates
adenosylcobalamin/alpha-ribazole phosphatase
alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate
BR47999 show the reaction diagram
R04594 show the reaction diagram
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natural substrates
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate
BR47999 show the reaction diagram
R04594 show the reaction diagram
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natural substrates
5,6-dimethylbenzimidazole synthase
FMNH2 + NADH + H+ + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD+ + other product
BR51095 show the reaction diagram
generic compounds
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natural substrates, generic
adenosylcobinamide hydrolase
adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol
BR48301 show the reaction diagram
R05226 show the reaction diagram
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natural substrates