Pathways

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BRENDA KEGG MetaCyc

vitamin B12 metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
precorrin-2 dehydrogenase
precorrin-2 + NAD+ = sirohydrochlorin + NADH + H+
: vitamin B12 metabolism,
heme metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Microbial metabolism in diverse environments,
Biosynthesis of cofactors
: siroheme biosynthesis,
factor 430 biosynthesis,
cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR47985show the reaction diagram
: R03947show the reaction diagram
: DIMETHUROPORDEHYDROG-RXNshow the reaction diagram
-
-
-
: multifunctional enzyme: siroheme synthase: precorrin-2 dehydrogenase (R03194+R03947+R02864) following after R03194, subsequently R02864
natural substrates
ferredoxin-NADP+ reductase
FMNH2 + NADP+ = FMN + NADPH + H+
: vitamin B12 metabolism
: Riboflavin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
: BR36899show the reaction diagram
: R05706show the reaction diagram
: FMNREDUCT-RXNshow the reaction diagram, RXN-12444show the reaction diagram
: 5302
-
-
-
: see R05705 (NADH)
natural substrates
FMNH2 + NADP+ = FMN + NADPH + H+
: vitamin B12 metabolism
: Riboflavin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
: BR36899show the reaction diagram
: R05706show the reaction diagram
: FMNREDUCT-RXNshow the reaction diagram, RXN-12444show the reaction diagram
: 5302
-
-
-
: see R05705 (NADH)
natural substrates
flavin reductase (NADPH)
FMNH2 + NADP+ = FMN + NADPH + H+
: vitamin B12 metabolism
: Riboflavin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
: BR36899show the reaction diagram
: R05706show the reaction diagram
: FMNREDUCT-RXNshow the reaction diagram, RXN-12444show the reaction diagram
: 5302
-
-
-
: see R05705 (NADH)
natural substrates
flavin reductase (NADH)
FMNH2 + NADP+ = FMN + NADPH + H+
: vitamin B12 metabolism
: Riboflavin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
: BR36899show the reaction diagram
: R05706show the reaction diagram
: FMNREDUCT-RXNshow the reaction diagram, RXN-12444show the reaction diagram
: 5302
-
-
-
: see R05705 (NADH)
natural substrates
FMN reductase (NADPH)
FMNH2 + NADP+ = FMN + NADPH + H+
: vitamin B12 metabolism
: Riboflavin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
: BR36899show the reaction diagram
: R05706show the reaction diagram
: FMNREDUCT-RXNshow the reaction diagram, RXN-12444show the reaction diagram
: 5302
-
-
-
: see R05705 (NADH)
natural substrates
FMN reductase [NAD(P)H]
FMNH2 + NADP+ = FMN + NADPH + H+
: vitamin B12 metabolism
: Riboflavin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
: BR36899show the reaction diagram
: R05706show the reaction diagram
: FMNREDUCT-RXNshow the reaction diagram, RXN-12444show the reaction diagram
: 5302
-
-
-
: see R05705 (NADH)
natural substrates
riboflavin reductase [NAD(P)H]
FMNH2 + NADP+ = FMN + NADPH + H+
: vitamin B12 metabolism
: Riboflavin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
: BR36899show the reaction diagram
: R05706show the reaction diagram
: FMNREDUCT-RXNshow the reaction diagram, RXN-12444show the reaction diagram
: 5302
-
-
-
: see R05705 (NADH)
natural substrates
FMN reductase (NADH)
FMNH2 + NADP+ = FMN + NADPH + H+
: vitamin B12 metabolism
: Riboflavin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
: BR36899show the reaction diagram
: R05706show the reaction diagram
: FMNREDUCT-RXNshow the reaction diagram, RXN-12444show the reaction diagram
: 5302
-
-
-
: see R05705 (NADH)
natural substrates
FAD reductase [NAD(P)H]
FMNH2 + NADP+ = FMN + NADPH + H+
: vitamin B12 metabolism
: Riboflavin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: 5,6-dimethylbenzimidazole biosynthesis I (aerobic),
bacterial bioluminescence,
two-component alkanesulfonate monooxygenase
: BR36899show the reaction diagram
: R05706show the reaction diagram
: FMNREDUCT-RXNshow the reaction diagram, RXN-12444show the reaction diagram
: 5302
-
-
-
: see R05705 (NADH)
natural substrates
aerobic 5,6-dimethylbenzimidazole synthase
FMNH2 + O2 = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + other product(s)
: vitamin B12 metabolism
: BR49224show the reaction diagram
generic compounds
-
-
-
natural substrates, generic
adenosylcobinamide-GDP ribazoletransferase
adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate = GMP + adenosylcobalamin 5'-phosphate
: vitamin B12 metabolism
: adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II,
adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I,
superpathway of adenosylcobalamin salvage from cobinamide II,
superpathway of adenosylcobalamin salvage from cobinamide I
: BS370846show the reaction diagram
: R11174show the reaction diagram
: COBALAMIN5PSYN-RXNshow the reaction diagram
: 14707
-
-
-
-
natural substrates
adenosylcobinamide-GDP ribazoletransferase
adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: BR47998show the reaction diagram
: R05223show the reaction diagram
: COBALAMINSYN-RXNshow the reaction diagram
: 4834
-
-
-
-
natural substrates
adenosylcobinamide kinase
Adenosyl cobinamide phosphate + GTP <=> Adenosine-GDP-cobinamide + Diphosphate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: adenosylcobinamide-GDP salvage from assorted adenosylcobamides,
adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide,
superpathway of adenosylcobalamin salvage from cobinamide II,
adenosylcobinamide-GDP salvage from cobinamide II,
superpathway of adenosylcobalamin salvage from cobinamide I,
adenosylcobinamide-GDP salvage from cobinamide I
: BR47996show the reaction diagram
: R05222show the reaction diagram
: COBINPGUANYLYLTRANS-RXNshow the reaction diagram
: 4833
-
-
-
-
natural substrates
adenosylcobinamide-phosphate guanylyltransferase
Adenosyl cobinamide phosphate + GTP <=> Adenosine-GDP-cobinamide + Diphosphate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: adenosylcobinamide-GDP salvage from assorted adenosylcobamides,
adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide,
superpathway of adenosylcobalamin salvage from cobinamide II,
adenosylcobinamide-GDP salvage from cobinamide II,
superpathway of adenosylcobalamin salvage from cobinamide I,
adenosylcobinamide-GDP salvage from cobinamide I
: BR47996show the reaction diagram
: R05222show the reaction diagram
: COBINPGUANYLYLTRANS-RXNshow the reaction diagram
: 4833
-
-
-
-
natural substrates
adenosylcobalamin/alpha-ribazole phosphatase
adenosylcobalamin 5'-phosphate + H2O = coenzyme B12 + phosphate
: vitamin B12 metabolism
: adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II,
adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I,
superpathway of adenosylcobalamin salvage from cobinamide II,
superpathway of adenosylcobalamin salvage from cobinamide I
: BR49541show the reaction diagram
: R11173show the reaction diagram
: RXN-8770show the reaction diagram
-
-
-
-
natural substrates
nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate + H+
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I,
superpathway of adenosylcobalamin salvage from cobinamide II,
superpathway of adenosylcobalamin salvage from cobinamide I
: BR44272show the reaction diagram
: R04148show the reaction diagram
: DMBPPRIBOSYLTRANS-RXNshow the reaction diagram
: 3868
-
-
-
-
natural substrates
nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate + H+
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: adenosylcobalamin biosynthesis from adenosylcobinamide-GDP I,
superpathway of adenosylcobalamin salvage from cobinamide II,
superpathway of adenosylcobalamin salvage from cobinamide I
: BR44272show the reaction diagram
: R04148show the reaction diagram
: DMBPPRIBOSYLTRANS-RXNshow the reaction diagram
: 3868
-
-
-
-
natural substrates
adenosylcobyric acid synthase (glutamine-hydrolysing)
4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide
: BR48011show the reaction diagram
: R05225show the reaction diagram
: R345-RXNshow the reaction diagram
-
-
-
: multi-step reaction
natural substrates, multi-step reaction
corrinoid adenosyltransferase
a reduced flavoprotein + 2 [corrinoid adenosyltransferase]-cob(II)yrinic acid a,c-diamide = an oxidized flavoprotein + 2 [corrinoid adenosyltransferase]-cob(I)yrinic acid a,c-diamide
: vitamin B12 metabolism
: BR52460show the reaction diagram
generic compounds
-
-
-
natural substrates, generic, protein
corrinoid adenosyltransferase
2 cob(II)yrinic acid a,c-diamide + 2 [corrinoid adenosyltransferase] = 2 [corrinoid adenosyltransferase]-cob(II)yrinic acid a,c-diamide
: vitamin B12 metabolism
: BR52459show the reaction diagram
n.a.
-
-
-
natural substrates
adenosylcobinamide-phosphate synthase
Adenosyl cobyrinate hexaamide + D-1-Aminopropan-2-ol O-phosphate + ATP <=> Adenosyl cobinamide phosphate + ADP + Orthophosphate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide,
superpathway of adenosylcobalamin salvage from cobinamide II,
adenosylcobinamide-GDP salvage from cobinamide II
: BR48012show the reaction diagram
: R06529show the reaction diagram
: RXN-6261show the reaction diagram
-
-
-
-
natural substrates
S-adenosyl-L-methionine + cobalt-precorrin-3B = S-adenosyl-L-homocysteine + cobalt-precorrin-4
: vitamin B12 metabolism
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BS375288show the reaction diagram
: R05809show the reaction diagram
: RXN-8761show the reaction diagram
-
-
-
: multi-step reaction
natural substrates, multi-step reaction
precorrin-3B C17-methyltransferase
S-adenosyl-L-methionine + cobalt-precorrin-3B = S-adenosyl-L-homocysteine + cobalt-precorrin-4
: vitamin B12 metabolism
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BS375288show the reaction diagram
: R05809show the reaction diagram
: RXN-8761show the reaction diagram
-
-
-
: multi-step reaction
natural substrates, multi-step reaction
cobalt-precorrin-4 methyltransferase
Cobalt-precorrin 4 + S-Adenosyl-L-methionine <=> Cobalt-precorrin 5A + S-Adenosyl-L-homocysteine
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR50534show the reaction diagram
: R05810show the reaction diagram
: RXN-8762show the reaction diagram
-
-
-
-
natural substrates
cobalt-factor II C20-methyltransferase
S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR47994show the reaction diagram
: R05808show the reaction diagram
: 2.1.1.151-RXNshow the reaction diagram
-
-
-
-
natural substrates, protein
sirohydrochlorin cobaltochelatase
cobalt-sirohydrochlorin + 2 H+ = sirohydrochlorin + Co2+
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR48008show the reaction diagram
: R05807show the reaction diagram
: 4.99.1.3-RXNshow the reaction diagram
-
-
-
-
natural substrates
sirohydrochlorin ferrochelatase
cobalt-sirohydrochlorin + 2 H+ = sirohydrochlorin + Co2+
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR48008show the reaction diagram
: R05807show the reaction diagram
: 4.99.1.3-RXNshow the reaction diagram
-
-
-
-
natural substrates
cobalt-precorrin 5A hydrolase
cobalt-precorrin-5A + H2O = cobalt-precorrin-5B + acetaldehyde + 2 H+
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR49393show the reaction diagram
: R07772show the reaction diagram
: RXN-8763show the reaction diagram
-
-
-
-
natural substrates
cobalt-precorrin-6A reductase
cobalt-precorrin-6B + NAD+ = cobalt-precorrin-6A + NADH + H+
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR50935show the reaction diagram
: R05812show the reaction diagram
: RXN-8765show the reaction diagram
-
-
-
-
natural substrates
cobalt-precorrin-7 (C5)-methyltransferase
cobalt-precorrin-7 + S-adenosyl-L-methionine = cobalt-precorrin-8 + S-adenosyl-L-homocysteine
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR50788show the reaction diagram
: R07775show the reaction diagram
: RXN-8767show the reaction diagram
-
-
-
-
natural substrates
cobalt-precorrin-8 methylmutase
cobalt-precorrin-8 = cobyrinate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR51009show the reaction diagram
: R05814show the reaction diagram
: RXN-8768show the reaction diagram
-
-
-
-
natural substrates
cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating]
cobalt-precorrin-6B + S-adenosyl-L-methionine + H+ = cobalt-precorrin-7 + S-adenosyl-L-homocysteine + CO2
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR49386show the reaction diagram
: R07774show the reaction diagram
: RXN-8766show the reaction diagram
-
-
-
: The enzyme from Pseudomonas denitrificans has S-adenosyl-L- methionine-dependent methyltransferase and decarboxylase activities.
natural substrates
cobalt-precorrin-5B (C1)-methyltransferase
cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR49385show the reaction diagram
: R07773show the reaction diagram
: RXN-8764show the reaction diagram
-
-
-
-
natural substrates
cobyrinate a,c-diamide synthase
2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR49510show the reaction diagram
: R05815show the reaction diagram
: RXN-8769show the reaction diagram
: 6681
-
-
-
: two-step reaction (see R09598+R09599)
natural substrates
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR49510show the reaction diagram
: R05815show the reaction diagram
: RXN-8769show the reaction diagram
: 6681
-
-
-
: two-step reaction (see R09598+R09599)
natural substrates
2 ATP + cobyrinate + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)
: BR49510show the reaction diagram
: R05815show the reaction diagram
: RXN-8769show the reaction diagram
: 6681
-
-
-
: two-step reaction (see R09598+R09599)
natural substrates
precorrin-3B synthase
precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR47982show the reaction diagram
: R05217show the reaction diagram
: R321-RXNshow the reaction diagram
-
-
-
: oxidoreduction, CobG, [Fe-S]
natural substrates
precorrin-3B C17-methyltransferase
S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR1454show the reaction diagram
: R05180show the reaction diagram
: 2.1.1.131-RXNshow the reaction diagram
-
-
-
-
natural substrates
precorrin-4 C11-methyltransferase
S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR6348show the reaction diagram
: R05181show the reaction diagram
: 2.1.1.133-RXNshow the reaction diagram
-
-
-
-
natural substrates
cobalt-precorrin-4 methyltransferase
S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin-5
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR6348show the reaction diagram
: R05181show the reaction diagram
: 2.1.1.133-RXNshow the reaction diagram
-
-
-
-
natural substrates
precorrin-2 C20-methyltransferase
S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A + H+
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR1453show the reaction diagram
: R03948show the reaction diagram
: 2.1.1.130-RXNshow the reaction diagram
-
-
-
-
natural substrates
precorrin-6A synthase (deacetylating)
S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR47993show the reaction diagram
: R05219show the reaction diagram
: R322-RXNshow the reaction diagram
-
-
-
-
natural substrates
precorrin-6B C5,15-methyltransferase (decarboxylating)
2 S-adenosyl-L-methionine + precorrin-6B = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: BR1455show the reaction diagram
: R05149show the reaction diagram
: 2.1.1.132-RXNshow the reaction diagram
-
-
-
-
natural substrates
precorrin-6A reductase
precorrin-6B + NADP+ = precorrin-6A + NADPH + H+
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR1202show the reaction diagram
: R05150show the reaction diagram
: 1.3.1.54-RXNshow the reaction diagram
-
-
-
-
natural substrates
precorrin-8X methylmutase
Precorrin-8X = hydrogenobyrinate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR16show the reaction diagram
: R05177show the reaction diagram
: 5.4.1.2-RXNshow the reaction diagram
: 4794
-
-
-
-
natural substrates
cobyrinate a,c-diamide synthase
2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR48014show the reaction diagram
: R05224show the reaction diagram
: R341-RXNshow the reaction diagram
: 4835
-
-
-
: multi-step reaction
natural substrates, multi-step reaction
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR48014show the reaction diagram
: R05224show the reaction diagram
: R341-RXNshow the reaction diagram
: 4835
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: multi-step reaction
natural substrates, multi-step reaction
cobaltochelatase
ATP + hydrogenobyrinic acid a,c-diamide + Co2+ + H2O = ADP + phosphate + cob(II)yrinic acid a,c-diamide
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
: BR48015show the reaction diagram
: R05227show the reaction diagram
: R342-RXNshow the reaction diagram
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natural substrates
adenosylcobalamin/alpha-ribazole phosphatase
alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: BR47999show the reaction diagram
: R04594show the reaction diagram
: RXN-16788show the reaction diagram
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natural substrates
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways,
Biosynthesis of cofactors
: BR47999show the reaction diagram
: R04594show the reaction diagram
: RXN-16788show the reaction diagram
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natural substrates
adenosylcobinamide hydrolase
adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol
: vitamin B12 metabolism
: Porphyrin metabolism,
Metabolic pathways
: superpathway of adenosylcobalamin salvage from cobinamide II,
adenosylcobinamide-GDP salvage from cobinamide II
: BR48301show the reaction diagram
: R05226show the reaction diagram
: R346-RXNshow the reaction diagram
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natural substrates
corrinoid adenosyltransferase
2 ATP + 2 [corrinoid adenosyltransferase]-cob(I)yrinic acid a,c-diamide = 2 triphosphate + 2 adenosylcob(III)yrinic acid a,c-diamide + 2 [corrinoid adenosyltransferase]
: vitamin B12 metabolism
: BR52461show the reaction diagram
n.a.
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natural substrates