histidine decarboxylase
Pathways
histidine metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
L-histidine = histamine + CO2
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natural substrates
phenylalanine decarboxylase
L-histidine = histamine + CO2
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natural substrates
L-histidinal + NAD+ + H2O = L-histidine + NADH + H+
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: second step of two-step reaction (R01158, R03012+R01163) following after R03012
natural substrates
histidinol dehydrogenase
L-histidinal + NAD+ + H2O = L-histidine + NADH + H+
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: second step of two-step reaction (R01158, R03012+R01163) following after R03012
natural substrates
L-histidinol + NAD+ = L-histidinal + NADH + H+
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: first step of two-step reaction (R01158, R03012+R01163) subsequently R01163
natural substrates
histidinol dehydrogenase
L-histidinol + NAD+ = L-histidinal + NADH + H+
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: first step of two-step reaction (R01158, R03012+R01163) subsequently R01163
natural substrates
histidinol-phosphatase
L-histidinol phosphate + H2O = L-histidinol + phosphate
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natural substrates
acid phosphatase
L-histidinol phosphate + H2O = L-histidinol + phosphate
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natural substrates
histidinol-phosphate transaminase
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
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natural substrates
imidazoleglycerol-phosphate dehydratase
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
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natural substrates
imidazole glycerol phosphate synthase
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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: two-step reaction (see R00256+R12152)
natural substrates
imidazole glycerol-phosphate synthase
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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: two-step reaction (see R00256+R12152)
natural substrates
N1-[(5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamido-1-beta-D-ribofuranosyl 5'-phosphate + L-glutamine = L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
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: two-step reaction (see R00256+R12152)
natural substrates
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
N-(5'-Phospho-D-ribosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide = N-(5'-Phospho-D-1-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide
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natural substrates
ribose-phosphate diphosphokinase
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
ATP phosphoribosyltransferase
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
phosphoribosyl-ATP diphosphatase
1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate
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natural substrates
phosphoribosyl-AMP cyclohydrolase
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
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natural substrates
histidine ammonia-lyase
L-histidine = urocanate + NH3
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natural substrates
urocanate hydratase
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O
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: multi-step reaction covalent intermediate with NAD+
natural substrates, multi-step reaction
imidazolonepropionase
(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+
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natural substrates
formimidoylglutamase
N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide
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natural substrates
glutamate formimidoyltransferase
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
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natural substrates
formimidoylglutamate deiminase
N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3
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natural substrates
N-formylglutamate deformylase
N-formyl-L-glutamate + H2O = formate + L-glutamate
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natural substrates
formylaspartate deformylase
N-formyl-L-glutamate + H2O = formate + L-glutamate
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natural substrates
aspartoacylase
N-formyl-L-aspartate + H2O = formate + L-aspartate
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natural substrates
formylaspartate deformylase
N-formyl-L-aspartate + H2O = formate + L-aspartate
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natural substrates
formimidoylglutamate deiminase
N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3
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natural substrates
formimidoylaspartate deiminase
N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3
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natural substrates
imidazoleacetate 4-monooxygenase
4-imidazoleacetate + NADH + H+ + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O
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natural substrates
putrescine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
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natural substrates
primary-amine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
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natural substrates
diamine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
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natural substrates
monoamine oxidase
histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2
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natural substrates
formimidoyltetrahydrofolate cyclodeaminase
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3
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natural substrates
methenyltetrahydrofolate cyclohydrolase
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate
: One carbon pool by folate,
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism,
Biosynthesis of cofactors
Carbon fixation pathways in prokaryotes,
Metabolic pathways,
Microbial metabolism in diverse environments,
Carbon metabolism,
Biosynthesis of cofactors
: reductive glycine pathway of autotrophic CO2 fixation,
folate transformations I,
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria),
purine nucleobases degradation I (anaerobic),
formaldehyde oxidation VII (THF pathway),
formate assimilation into 5,10-methylenetetrahydrofolate,
folate transformations III (E. coli),
folate transformations II (plants),
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate,
purine nucleobases degradation II (anaerobic),
L-histidine degradation III
folate transformations I,
reductive acetyl coenzyme A pathway I (homoacetogenic bacteria),
purine nucleobases degradation I (anaerobic),
formaldehyde oxidation VII (THF pathway),
formate assimilation into 5,10-methylenetetrahydrofolate,
folate transformations III (E. coli),
folate transformations II (plants),
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate,
purine nucleobases degradation II (anaerobic),
L-histidine degradation III
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natural substrates
tryptophan transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
histidine transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
2-aminoadipate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
tyrosine transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
aromatic-amino-acid transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
kynurenine-oxoglutarate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
histidinol-phosphate transaminase
L-histidine + 2-oxoglutarate = (imidazol-5-yl)pyruvate + L-glutamate
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natural substrates
3-(imidazol-5-yl)lactate dehydrogenase
(S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+
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: NAD+ (see R04185)
natural substrates
histidine transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
2-aminoadipate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
alanine-glyoxylate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
serine-pyruvate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
phenylalanine(histidine) transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
glutamine-phenylpyruvate transaminase
L-histidine + pyruvate = 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
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natural substrates
SPONTANEOUS
H+ + H2O + 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = formyl-isoglutamine
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: non-enzymatic
natural substrates
0.0.0.0
spontaneous reaction
H+ + H2O + 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = formyl-isoglutamine
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: non-enzymatic
natural substrates
H2O + formyl-isoglutamine = isoglutamine + formate
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natural substrates
0.0.0.0
spontaneous reaction
H2O + formyl-isoglutamine = isoglutamine + formate
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natural substrates
SPONTANEOUS
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = 4-oxoglutaramate + formate + NH3
incomplete
O2H2
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: multi-step reaction non-enzymatic incomplete reaction
natural substrates, multi-step reaction
0.0.0.0
spontaneous reaction
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = 4-oxoglutaramate + formate + NH3
incomplete
O2H2
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: multi-step reaction non-enzymatic incomplete reaction
natural substrates, multi-step reaction
SPONTANEOUS
H2O + 4-oxoglutaramate = 2-oxoglutarate + NH3 + H+
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: non-enzymatic hydrolysis
natural substrates
0.0.0.0
spontaneous reaction
H2O + 4-oxoglutaramate = 2-oxoglutarate + NH3 + H+
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: non-enzymatic hydrolysis
natural substrates
histidine-tRNA ligase
ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis
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natural substrates