Pathways

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BRENDA KEGG MetaCyc

leucine metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
alcohol dehydrogenase
3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+
: leucine metabolism
: 3-methylbutanol biosynthesis (engineered),
L-leucine degradation III
: BR26045_WOPThis reaction also exists with phosphate.show the reaction diagram
: R05685show the reaction diagram
: 1.1.1.265-RXN_WOPThis reaction also exists with phosphate.show the reaction diagram, RXN-7693show the reaction diagram
: 5281
-
-
-
: see R05686 (NADPH)
natural substrates
alcohol dehydrogenase (NADP+)
3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+
: leucine metabolism
: 3-methylbutanol biosynthesis (engineered),
L-leucine degradation III
: BR26045_WOPThis reaction also exists with phosphate.show the reaction diagram
: R05685show the reaction diagram
: 1.1.1.265-RXN_WOPThis reaction also exists with phosphate.show the reaction diagram, RXN-7693show the reaction diagram
: 5281
-
-
-
: see R05686 (NADPH)
natural substrates
3-methylbutanal reductase
3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+
: leucine metabolism
: 3-methylbutanol biosynthesis (engineered),
L-leucine degradation III
: BR26045_WOPThis reaction also exists with phosphate.show the reaction diagram
: R05685show the reaction diagram
: 1.1.1.265-RXN_WOPThis reaction also exists with phosphate.show the reaction diagram, RXN-7693show the reaction diagram
: 5281
-
-
-
: see R05686 (NADPH)
natural substrates
leucine 2,3-aminomutase
(2S)-alpha-leucine = (3R)-beta-leucine
: leucine metabolism
: L-leucine degradation II
: BR31show the reaction diagram, BS1198show the reaction diagram
: R01091show the reaction diagram
: LEUCINE-23-AMINOMUTASE-RXNshow the reaction diagram
-
-
-
-
natural substrates
alanine dehydrogenase
L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: BR33798show the reaction diagram
: R01088show the reaction diagram
: LEUCINE-DEHYDROGENASE-RXNshow the reaction diagram
: 1350
-
-
-
-
natural substrates
phenylalanine dehydrogenase
L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: BR33798show the reaction diagram
: R01088show the reaction diagram
: LEUCINE-DEHYDROGENASE-RXNshow the reaction diagram
: 1350
-
-
-
-
natural substrates
valine dehydrogenase (NAD+)
L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: BR33798show the reaction diagram
: R01088show the reaction diagram
: LEUCINE-DEHYDROGENASE-RXNshow the reaction diagram
: 1350
-
-
-
-
natural substrates
valine dehydrogenase (NADP+)
L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: BR33798show the reaction diagram
: R01088show the reaction diagram
: LEUCINE-DEHYDROGENASE-RXNshow the reaction diagram
: 1350
-
-
-
-
natural substrates
leucine dehydrogenase
L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH + H+
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites
: BR33798show the reaction diagram
: R01088show the reaction diagram
: LEUCINE-DEHYDROGENASE-RXNshow the reaction diagram
: 1350
-
-
-
-
natural substrates
SPONTANEOUS
(2S)-2-isopropyl-3-oxosuccinate + H+ = 4-methyl-2-oxopentanoate + CO2
: leucine metabolism
: Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
: L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
: BR52894show the reaction diagram
: R01652show the reaction diagram
: RXN-7800show the reaction diagram
-
-
-
: spontaneous (following EC 1.1.1.85 or R04426 reaction)
natural substrates
0.0.0.0
spontaneous reaction
(2S)-2-isopropyl-3-oxosuccinate + H+ = 4-methyl-2-oxopentanoate + CO2
: leucine metabolism
: Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
: L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
: BR52894show the reaction diagram
: R01652show the reaction diagram
: RXN-7800show the reaction diagram
-
-
-
: spontaneous (following EC 1.1.1.85 or R04426 reaction)
natural substrates
3-isopropylmalate dehydrogenase
(2S)-2-isopropyl-3-oxosuccinate + H+ = 4-methyl-2-oxopentanoate + CO2
: leucine metabolism
: Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
: L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
: BR52894show the reaction diagram
: R01652show the reaction diagram
: RXN-7800show the reaction diagram
-
-
-
: spontaneous (following EC 1.1.1.85 or R04426 reaction)
natural substrates
(2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
: leucine metabolism
: Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
: L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
: BR47597show the reaction diagram, BS371258show the reaction diagram, BS373119show the reaction diagram
: R04426show the reaction diagram
: 3-ISOPROPYLMALDEHYDROG-RXNshow the reaction diagram
-
-
-
: subsequently R01652
natural substrates
3-isopropylmalate dehydrogenase
(2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
: leucine metabolism
: Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
: L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
: BR47597show the reaction diagram, BS371258show the reaction diagram, BS373119show the reaction diagram
: R04426show the reaction diagram
: 3-ISOPROPYLMALDEHYDROG-RXNshow the reaction diagram
-
-
-
: subsequently R01652
natural substrates
3-isopropylmalate dehydratase
(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O
: leucine metabolism
: Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
: L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
: BR413show the reaction diagram, BR49521show the reaction diagram, BS1964show the reaction diagram
: R03968show the reaction diagram, R04001show the reaction diagram
: 3-ISOPROPYLMALISOM-RXNshow the reaction diagram, RXN-8991show the reaction diagram
: 3704, 3736
-
-
-
: Catalyzes the isomerization between (2R,3S)-3-isopropylmalate and 3-hydroxy-4-methyl-3-carboxypentanoate, via the formation of (2S)-2 isopropylmaleate.
natural substrates
(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O
: leucine metabolism
: Valine, leucine and isoleucine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism
: L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
: BR413show the reaction diagram, BR49521show the reaction diagram, BS1964show the reaction diagram
: R03968show the reaction diagram, R04001show the reaction diagram
: 3-ISOPROPYLMALISOM-RXNshow the reaction diagram, RXN-8991show the reaction diagram
: 3704, 3736
-
-
-
: Catalyzes the isomerization between (2R,3S)-3-isopropylmalate and 3-hydroxy-4-methyl-3-carboxypentanoate, via the formation of (2S)-2 isopropylmaleate.
natural substrates
2-isopropylmalate synthase
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA
: leucine metabolism
: Valine, leucine and isoleucine biosynthesis,
Pyruvate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
: BR47381show the reaction diagram, BS353415show the reaction diagram, BS375022show the reaction diagram, BS438748show the reaction diagram
: R01213show the reaction diagram
: 2-ISOPROPYLMALATESYN-RXNshow the reaction diagram
: 545
-
-
-
-
natural substrates
methylthioalkylmalate synthase
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA
: leucine metabolism
: Valine, leucine and isoleucine biosynthesis,
Pyruvate metabolism,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine biosynthesis,
3-methylbutanol biosynthesis (engineered)
: BR47381show the reaction diagram, BS353415show the reaction diagram, BS375022show the reaction diagram, BS438748show the reaction diagram
: R01213show the reaction diagram
: 2-ISOPROPYLMALATESYN-RXNshow the reaction diagram
: 545
-
-
-
-
natural substrates
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
2-ketoisocaproate + CoA + oxidized ferredoxin = S-(3-methylbutanoyl)-CoA + CO2 + reduced ferredoxin
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Metabolic pathways
: L-leucine degradation V (oxidative Stickland reaction)
: BS359415show the reaction diagram
: R08566show the reaction diagram
: RXN-19534show the reaction diagram
-
-
-
-
natural substrates, generic, protein
indolepyruvate ferredoxin oxidoreductase
2-ketoisocaproate + CoA + oxidized ferredoxin = S-(3-methylbutanoyl)-CoA + CO2 + reduced ferredoxin
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Metabolic pathways
: L-leucine degradation V (oxidative Stickland reaction)
: BS359415show the reaction diagram
: R08566show the reaction diagram
: RXN-19534show the reaction diagram
-
-
-
-
natural substrates, generic, protein
isovaleryl-CoA dehydrogenase
isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Metabolic pathways
: BS424839show the reaction diagram
: R04095show the reaction diagram
: 3822
-
-
-
-
natural substrates
medium-chain acyl-CoA dehydrogenase
isovaleryl-CoA + FAD = 3-methylcrotonyl-CoA + FADH2
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Metabolic pathways
: BS424839show the reaction diagram
: R04095show the reaction diagram
: 3822
-
-
-
-
natural substrates
methylcrotonoyl-CoA carboxylase
ATP + 3-methylcrotonoyl-CoA + HCO3- + H+ = ADP + phosphate + 3-methylglutaconyl-CoA
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Metabolic pathways
: L-leucine degradation I
: BR156show the reaction diagram
: R04138show the reaction diagram
: METHYLCROTONYL-COA-CARBOXYLASE-RXNshow the reaction diagram
: 3859
-
-
-
-
natural substrates
geranoyl-CoA carboxylase
ATP + 3-methylcrotonoyl-CoA + HCO3- + H+ = ADP + phosphate + 3-methylglutaconyl-CoA
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Metabolic pathways
: L-leucine degradation I
: BR156show the reaction diagram
: R04138show the reaction diagram
: METHYLCROTONYL-COA-CARBOXYLASE-RXNshow the reaction diagram
: 3859
-
-
-
-
natural substrates
methylglutaconyl-CoA hydratase
(S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Metabolic pathways
: ferrichrome A biosynthesis,
L-leucine degradation I
: BR3388show the reaction diagram
: R02085show the reaction diagram
: METHYLGLUTACONYL-COA-HYDRATASE-RXNshow the reaction diagram
: 2095
-
-
-
-
natural substrates
hydroxymethylglutaryl-CoA lyase
(S)-3-Hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Butanoate metabolism,
Metabolic pathways
: mevalonate degradation,
L-leucine degradation I,
ketogenesis
: BR395show the reaction diagram, BS416230show the reaction diagram
: R01360show the reaction diagram
: HYDROXYMETHYLGLUTARYL-COA-LYASE-RXNshow the reaction diagram
: 1564
-
-
-
-
natural substrates
aspartate transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
alanine transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
2-aminoadipate transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
branched-chain-amino-acid transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
tyrosine transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
aromatic-amino-acid transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
leucine transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
2-aminohexanoate transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
methionine transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
histidinol-phosphate transaminase
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
: leucine metabolism
: Valine, leucine and isoleucine degradation,
Valine, leucine and isoleucine biosynthesis,
Glucosinolate biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
2-Oxocarboxylic acid metabolism,
Biosynthesis of amino acids
: L-leucine degradation IV (reductive Stickland reaction),
L-leucine degradation V (oxidative Stickland reaction),
odd iso-branched-chain fatty acid biosynthesis,
L-leucine biosynthesis,
L-leucine degradation I,
L-leucine degradation III
: BR47691show the reaction diagram
: R01090show the reaction diagram
: BRANCHED-CHAINAMINOTRANSFERLEU-RXNshow the reaction diagram
: 1352
-
-
-
-
natural substrates
leucine-tRNA ligase
ATP + L-leucine + tRNALeu = AMP + diphosphate + L-leucyl-tRNALeu
: leucine metabolism
: Aminoacyl-tRNA biosynthesis
: BR55show the reaction diagram
: R03657show the reaction diagram
: 412
-
-
-
-
natural substrates
(R)-2-hydroxy-4-methylpentanoate CoA-transferase
4-methylpentanoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpentanoate + (R)-2-hydroxy-4-methylpentanoyl-CoA
: leucine metabolism
: L-leucine degradation IV (reductive Stickland reaction)
: BR51714show the reaction diagram
: R11462show the reaction diagram
: RXN-16246show the reaction diagram
-
-
-
-
natural substrates
(R)-2-hydroxyisocaproyl-CoA dehydratase
(R)-2-hydroxy-4-methylpentanoyl-CoA = 4-methylpent-2-enoyl-CoA + H2O
: leucine metabolism
: L-leucine degradation IV (reductive Stickland reaction)
: BR51460show the reaction diagram
: R11076show the reaction diagram
: RXN-16247show the reaction diagram
: 15549
-
-
-
-
natural substrates
(R)-2-hydroxyisocaproate CoA transferase
4-methylpent-2-enoyl-CoA + (R)-2-hydroxy-4-methylpentanoate = 4-methylpent-2-enoate + (R)-2-hydroxy-4-methylpentanoyl-CoA
: leucine metabolism
: BR51452show the reaction diagram
-
-
-
-
natural substrates
trans-2-enoyl-CoA reductase (NAD+)
acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH + H+
: leucine metabolism
: BR36826show the reaction diagram, BS370148show the reaction diagram
: R00384show the reaction diagram
-
-
-
: general reaction
natural substrates, generic