Print
dCTP diphosphatase
Pathways
pyrimidine metabolism (BRENDA)
:= BRENDA, 
:= KEGG, 
:= MetaCyc, 
:= SABIO-RK
:= amino acid sequences 
:= show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
dCTP + H2O = dCMP + diphosphate
; "show the reaction diagram")
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natural substrates
dUTP diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
8-oxo-dGTP diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
(d)CTP diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
ATP diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
nucleotide diphosphatase
dCTP + H2O = dCMP + diphosphate
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natural substrates
dihydroorotate dehydrogenase (NAD+)
dihydroorotate + NAD+ = orotate + NADH + H+
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natural substrates
purine nucleosidase
cytidine + H2O = D-ribose + cytosine
; "show the reaction diagram")
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natural substrates
uridine nucleosidase
cytidine + H2O = D-ribose + cytosine
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natural substrates
adenosine nucleosidase
cytidine + H2O = D-ribose + cytosine
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natural substrates
ribosylpyrimidine nucleosidase
cytidine + H2O = D-ribose + cytosine
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natural substrates
purine nucleosidase
uridine + H2O = D-ribose + uracil
; "show the reaction diagram")
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natural substrates
uridine nucleosidase
uridine + H2O = D-ribose + uracil
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natural substrates
adenosine nucleosidase
uridine + H2O = D-ribose + uracil
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natural substrates
ribosylpyrimidine nucleosidase
uridine + H2O = D-ribose + uracil
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natural substrates
dCMP deaminase
dCMP + H2O = dUMP + NH3
; "show the reaction diagram")
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natural substrates
dCTP diphosphatase
dCDP + H2O = dCMP + phosphate
; "show the reaction diagram")
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natural substrates
nucleoside-triphosphate phosphatase
dCDP + H2O = dCMP + phosphate
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natural substrates
8-oxo-dGTP diphosphatase
dCDP + H2O = dCMP + phosphate
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natural substrates
nucleoside diphosphate phosphatase
dCDP + H2O = dCMP + phosphate
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natural substrates
nucleotide diphosphatase
dCDP + H2O = dCMP + phosphate
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natural substrates
dihydropyrimidine dehydrogenase (NAD+)
thymine + NADPH + H+ = dihydrothymine + NADP+
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natural substrates
dihydropyrimidine dehydrogenase (NADP+)
thymine + NADPH + H+ = dihydrothymine + NADP+
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natural substrates
dihydropyrimidinase
beta-ureidoisobutyrate = dihydrothymine + H2O
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natural substrates
(R)-3-amino-2-methylpropionate-pyruvate transaminase
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
; "show the reaction diagram")
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natural substrates
beta-ureidopropionase
2-methyl-N-carbamoyl-beta-alanine + H2O = 2-methyl-beta-alanine + CO2 + NH3
; "show the reaction diagram")
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natural substrates
ribonucleoside-triphosphate reductase (formate)
CTP + formate = dCTP + CO2 + H2O
; "show the reaction diagram")
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natural substrates
nucleoside-diphosphate kinase
ATP + dCDP = ADP + dCTP
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
; "show the reaction diagram")
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natural substrates
ribonucleoside-diphosphate reductase
CDP + reduced thioredoxin = dCDP + oxidized thioredoxin + H2O
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
; "show the reaction diagram")
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natural substrates
ribonucleoside-triphosphate reductase (thioredoxin)
CDP + reduced thioredoxin = dCDP + oxidized thioredoxin + H2O
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
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natural substrates
adenylate kinase
ATP + CDP = ADP + CTP
; "show the reaction diagram")
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natural substrates
nucleoside-diphosphate kinase
ATP + CDP = ADP + CTP
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natural substrates
CTP synthase (glutamine hydrolysing)
ATP + UTP + L-Glutamine + H2O <=> ADP + Orthophosphate + CTP + L-Glutamate
; "show the reaction diagram")
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: two-step reaction (see R00256+R00571)natural substrates
nucleoside-diphosphate kinase
ATP + UDP = ADP + UTP
; "show the reaction diagram")
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natural substrates
UMP/CMP kinase
ATP + UMP = ADP + UDP
; "show the reaction diagram")
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natural substrates
UMP kinase
ATP + UMP = ADP + UDP
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natural substrates
(d)CMP kinase
ATP + UMP = ADP + UDP
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natural substrates
nucleoside-phosphate kinase
ATP + UMP = ADP + UDP
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natural substrates
guanylate kinase
ATP + UMP = ADP + UDP
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natural substrates
orotidine-5'-phosphate decarboxylase
orotidine 5'-phosphate = UMP + CO2
; "show the reaction diagram")
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natural substrates
orotate phosphoribosyltransferase
orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
; "show the reaction diagram")
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natural substrates
dihydroorotate dehydrogenase (quinone)
(S)-dihydroorotate + ubiquinone = orotate + ubiquinol
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natural substrates
dihydroorotase
dihydroorotate + H2O = N-carbamoyl-L-aspartate
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aspartate carbamoyltransferase
carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate
; "show the reaction diagram")
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natural substrates
dCTP deaminase
dCTP + H2O = dUTP + NH3
; "show the reaction diagram")
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natural substrates
ribonucleoside-diphosphate reductase
UDP + reduced thioredoxin = dUDP + oxidized thioredoxin + H2O
; "show the reaction diagram")
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natural substrates, generic
ribonucleoside-triphosphate reductase (thioredoxin)
UDP + reduced thioredoxin = dUDP + oxidized thioredoxin + H2O
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natural substrates, generic
nucleoside-diphosphate kinase
ADP + dUTP = ATP + dUDP
; "show the reaction diagram")
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natural substrates
ribonucleoside-triphosphate reductase (formate)
UTP + formate = dUTP + CO2 + H2O
; "show the reaction diagram")
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natural substrates
dUTP diphosphatase
dUTP + H2O = dUMP + diphosphate
; "show the reaction diagram")
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natural substrates
ATP diphosphatase
dUTP + H2O = dUMP + diphosphate
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natural substrates
nucleotide diphosphatase
dUTP + H2O = dUMP + diphosphate
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natural substrates
thymidylate synthase
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
: dTMP de novo biosynthesis (mitochondrial),folate transformations III (E. coli),
folate transformations II (plants),
pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleosides salvage,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II
; "show the reaction diagram")
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natural substrates
thymidine kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
; "show the reaction diagram")
; "show the reaction diagram")
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natural substrates
T2-induced deoxynucleotide kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
(deoxy)nucleoside-phosphate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
thiamine-phosphate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
adenylate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
nucleoside-phosphate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
guanylate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
dTMP kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
nucleoside-diphosphate kinase
ATP + dTDP = ADP + dTTP
: pyrimidine deoxyribonucleotides biosynthesis from CTP,pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II
; "show the reaction diagram")
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natural substrates
thymidine kinase
2'-deoxyuridine + ATP = 2'-deoxyuridine 5'-phosphate + ADP
; "show the reaction diagram")
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natural substrates
deoxycytidine kinase
2'-deoxyuridine + ATP = 2'-deoxyuridine 5'-phosphate + ADP
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natural substrates
2'-deoxyadenosine kinase
2'-deoxyuridine + ATP = 2'-deoxyuridine 5'-phosphate + ADP
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natural substrates
deoxyguanosine kinase
2'-deoxyuridine + ATP = 2'-deoxyuridine 5'-phosphate + ADP
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natural substrates
deoxynucleoside kinase
2'-deoxyuridine + ATP = 2'-deoxyuridine 5'-phosphate + ADP
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natural substrates
dCMP deaminase
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
; "show the reaction diagram")
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natural substrates
cytidine deaminase
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3
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natural substrates
pyrimidine-nucleoside phosphorylase
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
; "show the reaction diagram")
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natural substrates
uridine phosphorylase
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
thymidine phosphorylase
2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
pyrimidine-nucleoside phosphorylase
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
; "show the reaction diagram")
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natural substrates
uridine phosphorylase
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
thymidine phosphorylase
thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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natural substrates
cytidine deaminase
cytidine + H2O = uridine + NH3
; "show the reaction diagram")
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natural substrates
pyrimidine-nucleoside phosphorylase
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
; "show the reaction diagram")
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natural substrates
uridine phosphorylase
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
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natural substrates
thymidine phosphorylase
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate
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natural substrates
thymidine kinase
ATP + thymidine = ADP + dTMP
; "show the reaction diagram")
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natural substrates
deoxycytidine kinase
ATP + thymidine = ADP + dTMP
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natural substrates
2'-deoxyadenosine kinase
ATP + thymidine = ADP + dTMP
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natural substrates
nucleoside phosphotransferase
ATP + thymidine = ADP + dTMP
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natural substrates
dTMP kinase
ATP + thymidine = ADP + dTMP
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natural substrates
deoxyguanosine kinase
ATP + thymidine = ADP + dTMP
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natural substrates
deoxynucleoside kinase
ATP + thymidine = ADP + dTMP
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natural substrates
uridine/cytidine kinase
GTP + uridine = UMP + GDP
; "show the reaction diagram")
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natural substrates
orotate phosphoribosyltransferase
UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
; "show the reaction diagram")
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natural substrates
uracil phosphoribosyltransferase
UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate
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natural substrates
cytosine deaminase
cytosine + H2O = uracil + NH3
; "show the reaction diagram")
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natural substrates
guanine deaminase
cytosine + H2O = uracil + NH3
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natural substrates
cytidine kinase
GTP + cytidine = CMP + GDP
; "show the reaction diagram")
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natural substrates
uridine/cytidine kinase
GTP + cytidine = CMP + GDP
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natural substrates
broad specificity nucleoside kinase
GTP + cytidine = CMP + GDP
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natural substrates
uridine/cytidine kinase
ATP + CMP = ADP + CDP
; "show the reaction diagram")
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natural substrates
UMP/CMP kinase
ATP + CMP = ADP + CDP
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natural substrates
(d)CMP kinase
ATP + CMP = ADP + CDP
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natural substrates
adenylate kinase
ATP + CMP = ADP + CDP
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natural substrates
nucleoside-phosphate kinase
ATP + CMP = ADP + CDP
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natural substrates
guanylate kinase
ATP + CMP = ADP + CDP
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natural substrates
dihydroorotate dehydrogenase (quinone)
dihydroorotate + O2 = orotate + H2O2
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dihydroorotate dehydrogenase (fumarate)
dihydroorotate + O2 = orotate + H2O2
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thymidylate synthase (FAD)
5,10-methylenetetrahydrofolate + dUMP + FADH2 = dTMP + tetrahydrofolate + FAD
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natural substrates
dCTP deaminase (dUMP-forming)
dCTP + 2 H2O = dUMP + diphosphate + NH3
; "show the reaction diagram")
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natural substrates
CTP + H2O = CMP + diphosphate
; "show the reaction diagram")
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natural substrates
(d)CTP diphosphatase
CTP + H2O = CMP + diphosphate
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natural substrates
ATP diphosphatase
CTP + H2O = CMP + diphosphate
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natural substrates
nucleotide diphosphatase
CTP + H2O = CMP + diphosphate
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natural substrates
CMP + H2O = cytidine + phosphate
; "show the reaction diagram")
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natural substrates
alkaline phosphatase
CMP + H2O = cytidine + phosphate
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natural substrates
acid phosphatase
CMP + H2O = cytidine + phosphate
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natural substrates
inositol-phosphate phosphatase
CMP + H2O = cytidine + phosphate
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natural substrates
5'-nucleotidase
CMP + H2O = cytidine + phosphate
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natural substrates
7-methylguanosine nucleotidase
CMP + H2O = cytidine + phosphate
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natural substrates