urea carboxylase
Pathways
urea cycle (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
ATP + urea + HCO3- + H+ = ADP + phosphate + urea-1-carboxylate
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natural substrates
allophanate hydrolase
urea-1-carboxylate + H2O = 2 CO2 + 2 NH3
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: The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 6.3.4.6 urea carboxylase, thus bringing about the hydrolysis of urea to CO2 and NH3 in the presence of ATP and bicarbonate. R00774 (6.3.4.6)
natural substrates
arginase
L-arginine + H2O = L-ornithine + urea
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natural substrates
guanidinobutyrase
L-arginine + H2O = L-ornithine + urea
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natural substrates
argininosuccinate lyase
2-(Nomega-L-arginino)succinate = fumarate + L-arginine
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natural substrates
adenylosuccinate lyase
2-(Nomega-L-arginino)succinate = fumarate + L-arginine
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natural substrates
citrullinase
L-citrulline + H2O = L-ornithine + CO2 + NH3
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natural substrates
beta-ureidopropionase
L-citrulline + H2O = L-ornithine + CO2 + NH3
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natural substrates
ornithine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine biosynthesis IV (archaea),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis II (acetyl cycle),
urea cycle
L-arginine biosynthesis IV (archaea),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis II (acetyl cycle),
urea cycle
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natural substrates
putrescine carbamoyltransferase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine biosynthesis IV (archaea),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis II (acetyl cycle),
urea cycle
L-arginine biosynthesis IV (archaea),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis II (acetyl cycle),
urea cycle
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natural substrates
agmatine deiminase
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
: Arginine biosynthesis,
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
Metabolic pathways,
Biosynthesis of secondary metabolites,
Biosynthesis of amino acids
: L-arginine degradation XIV (oxidative Stickland reaction),
L-arginine biosynthesis IV (archaea),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis II (acetyl cycle),
urea cycle
L-arginine biosynthesis IV (archaea),
L-arginine degradation XIII (reductive Stickland reaction),
L-arginine biosynthesis I (via L-ornithine),
L-citrulline degradation,
L-citrulline biosynthesis,
L-arginine biosynthesis II (acetyl cycle),
urea cycle
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natural substrates
argininosuccinate synthase
ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nomega-L-arginino)succinate
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natural substrates
carbamate kinase
ATP + NH3 + hydrogencarbonate = ADP + carbamoyl phosphate + H2O
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: two-step reaction (see R01395+R12185)
natural substrates
urease
urea + H2O = CO2 + 2 NH3
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natural substrates