aminopyrimidine aminohydrolase
Pathways
vitamin B1 metabolism (BRENDA)
:= BRENDA, := KEGG, := MetaCyc, := SABIO-RK
:= amino acid sequences := show the reaction diagram
EC Number
Reaction
Pathways
Reaction IDs
Stoichiometry Check
Missing Substrate
Missing Product
Commentary
Remark
thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole
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natural substrates
hydroxyethylthiazole kinase
ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphooxyethyl)thiazole
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natural substrates
1-deoxy-D-xylulose-5-phosphate synthase
pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2
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natural substrates
hydroxymethylpyrimidine kinase
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
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natural substrates
phosphooxymethylpyrimidine kinase
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
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natural substrates
phosphomethylpyrimidine synthase
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
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natural substrates
pyridoxal kinase
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
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natural substrates
hydroxymethylpyrimidine kinase
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
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natural substrates
phosphooxymethylpyrimidine kinase
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine
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natural substrates
thiamine phosphate synthase
4-amino-2-methyl-5-(diphosphomethyl)pyrimidine + 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = diphosphate + thiamine phosphate + CO2
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: Studies with the enzyme from Bacillus subtilis suggested that the preferred substrate for the enzyme in vivo is CPD-13576 [21534620]. However, the enzyme also accepts |FRAME:THZ-P| with similar efficiency.
natural substrates
thiamine kinase
ATP + thiamine = ADP + thiamine phosphate
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natural substrates
thymidine kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
T2-induced deoxynucleotide kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
(deoxy)nucleoside-phosphate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
thiamine-phosphate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
adenylate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
nucleoside-phosphate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
guanylate kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
dTMP kinase
ATP + thiamine phosphate = ADP + thiamine diphosphate
: Thiamine metabolism,
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
Metabolic pathways,
Biosynthesis of cofactors,
Pyrimidine metabolism,
Nucleotide metabolism
: pyrimidine deoxyribonucleotides biosynthesis from CTP,
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
pyrimidine deoxyribonucleotide phosphorylation,
pyrimidine deoxyribonucleotides de novo biosynthesis IV,
pyrimidine deoxyribonucleotides de novo biosynthesis I,
pyrimidine deoxyribonucleotides de novo biosynthesis III,
superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli),
pyrimidine deoxyribonucleotides de novo biosynthesis II,
thiamine diphosphate salvage II,
thiamine diphosphate biosynthesis II (Bacillus),
thiamine diphosphate biosynthesis I (E. coli),
thiamine diphosphate salvage I
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natural substrates
thiamine diphosphokinase
ATP + thiamine = AMP + thiamine diphosphate
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natural substrates
alkaline phosphatase
thiamine phosphate + H2O = thiamine + phosphate
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natural substrates
thiamine phosphate phosphatase
thiamine phosphate + H2O = thiamine + phosphate
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natural substrates
acid phosphatase
thiamine phosphate + H2O = thiamine + phosphate
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natural substrates
cysteine-dependent adenosine diphosphate thiazole synthase
NAD+ + glycine + [ADP-thiazole synthase]-L-cysteine = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]-dehydroalanine + 3 H2O
: BR52385
n.a.
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natural substrates
cysteine desulfurase
L-cysteine + [ThiI]-cysteine = L-alanine + [ThiI]-S-sulfanylcysteine
: BS426551
n.a.
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sulfur carrier protein ThiS adenylyltransferase
ATP + [ThiS] = diphosphate + adenylyl-[ThiS]
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natural substrates, protein
2-iminoacetate synthase
L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+
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natural substrates
thiazole synthase
1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O
: BS416005
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natural substrates, protein
thiamine phosphate synthase
4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)thiazole = diphosphate + thiamine phosphate
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natural substrates